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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, chloro-

RTECS #

KH7525000

CAS #

75-00-3

Updated

September 201

Molecular Weight

64.52

Molecular Formula

C2H5Cl

Synonyms

Aethylchlorid (German)
Aethylis
Aethylis chloridum
Anodynon
Chelen
Chloorethaan (Dutch)
Chlorene
Chlorethyl
Chloroaethan (German)
Chloroethane
Chloroethyl
Chlorure d'ethyle (French)
Chloryl
Chloryl anesthetic
Cloretilo
Cloroetano (Italian)
Cloruro di etile (Italian)
Dublofix
Ether chloratus
Ether chloridum
Ether hydrochloric
Ether muriatic
Ethyl chloride
Ethyl chloride (ACGIH:OSHA)
Etylu chlorek (Polish)
Hydrochloric ether
Kelene
Monochlorethane
Monochloroethane
Muriatic ether
Narcotile
NCI-C06224

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster20 pph/6H (-enzymatic activation step)MUREAV 652,122,2008
Cytogenetic Analysislung/hamster30 pph/6H (+enzymatic activation step)MUREAV 652,122,2008
mutation in mammalian somatic cellsovary/hamster2340 mg/LMUREAV 322,33,1994
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+/-enzymatic activation step)NTPTR* NTP-TR-346,1988
mutation in microorganisms/Escherichia coli1 pph (+/-enzymatic activation step)MUREAV 307,335,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 60 mg/m3/4H (26W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GTPZAB 10(2),37,1966

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 15000 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Uterine tumors		NTPTR* NTP-TR-346,1989
inhalation/mouse lowest published toxic concentration: 927000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors		NTIS** PB90-225053/AS
inhalation/rat lowest published toxic concentration: 15000 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors		NTPTR* NTP-TR-346,1989
inhalation/rat lowest published toxic concentration: 463500 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors		NTIS** PB90-225053/AS
inhalation/rat lowest published toxic concentration: 386250 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors		NTIS** PB90-225053/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 40000 ppm/45MBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema		XPHBAO 185,1,1929
inhalation/guinea pig Lowest published lethal concentration: 260000 mg/m3/90MVCVGH* -,353,1990
inhalation/human lowest published toxic concentration: 3 pph/1MBehavioral: General anestheticVCVGH* -,353,1990
inhalation/human lowest published toxic concentration: 4 pphEye: Conjunctiva irritation

Gastrointestinal: Other changes		VCVGH* -,353,1990
inhalation/human lowest published toxic concentration: 90000 mg/m3/8MBehavioral: AtaxiaVCVGH* -,353,1990
inhalation/human lowest published toxic concentration: 35000 mg/m3/20MBehavioral: General anestheticVCVGH* -,353,1990
inhalation/mouse lethal concentration (50 percent kill): 121300 mg/m3/2HVCVGH* -,353,1990
inhalation/mouse lowest published toxic concentration: 140000 mg/m3/2HBehavioral: General anestheticVCVGH* -,353,1990
inhalation/rat lethal concentration (50 percent kill): 150000 mg/m3/2HVCVGH* -,353,1990
inhalation/rat lethal concentration (50 percent kill): 152 gm/m3/2HBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic

Blood: Hemorrhage		TPKVAL 6,45,1964
inhalation/rat Lowest published lethal concentration: 145 gm/m3/10MBrain and Coverings: Changes in circulation

Vascular: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance		TPKVAL 6,45,1964
inhalation/rat lethal concentration (50 percent kill): 152 gm/m3/10MGastrointestinal: Necrotic changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney		TPKVAL 6,45,1964
inhalation/rat lowest published toxic concentration: 140 gm/m3/2HKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage		TPKVAL 6,45,1964
oral/mouse lowest published toxic dose: 600 mg/kgLiver: Other changes

Lung, Thorax, or Respiration: Other changes		TOXID9 72(Suppl 1),323,2003
oral/rat lowest published toxic dose: 250 mg/kgLiver: Other changes

Lung, Thorax, or Respiration: Other changes		TOXID9 72(Suppl 1),323,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 5000 ppm/23H/11D- intermittentLiver: Changes in liver weightFAATDF 13,516,1989
inhalation/mouse lowest published toxic concentration: 19000 ppm/6H/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-346,1989
inhalation/mouse lowest published toxic concentration: 15000 ppm/21D- continuousEndocrine: Effect on menstrual cycleTXAPA9 130,169,1995
inhalation/rat lowest published toxic concentration: 14 gm/m3/60D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Immunological Including Allergic: Decrease in cellular immune response		TPKVAL 6,45,1964
inhalation/rat lowest published toxic concentration: 19000 ppm/6H/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-346,1989
inhalation/rat lowest published toxic concentration: 14 gm/m3/2H/60D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Immunological Including Allergic: Decrease in cellular immune response		GTPZAB 10(2),37,1966
inhalation/rat lowest published toxic concentration: 570 mg/m3/4H/26W- intermittentLiver: Liver function tests impaired

Immunological Including Allergic: Decrease in cellular immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		GTPZAB 10(2),37,1966

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 52,315,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1345,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 52,315,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1345,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1345,1999
TOXICOLOGY REVIEWAIHAAP 40(3),A46,1979
TOXICOLOGY REVIEWJFSCAS 45,223,2000
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTIHEEC 24,655,2008

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (2600 mg/m3)DTLVS* 3,106,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (2640 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 9 ppm (25 mg/m3);KZW 36 ppm (100 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (268 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (264 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-ECtime-weighted average 268 mg/m3 (100 ppm), FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (268 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (2600 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (264 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (260 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (2600 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (2600 mg/m3);short term exposure limit 1250 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (2640 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 500 ppm (1300 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (264 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 1600 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (1300 mg/m3);short term exposure limit 700 ppm (1900 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 9 ppm (25 mg/m3), carc 3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2600 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (2600 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (2600 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (134 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (2600 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (2600 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (2600 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (2600 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MONOCHLOROETHANE-airHandle with cautionNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 31970; Number of Industries 12; Total Number of Facilities 766; Number of Occupations 47; Total Number of Employees Exposed 49210; Total Number of Female Employees Exposed 35368
National Occupational Hazard Survey 1974Hazard Code 31970; Number of Industries 80; Total Number of Facilities 6154; Number of Occupations 66; Total Number of Employees Exposed 96531

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/121956)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NIOSH Analytical Method, 1994: Ethyl chloride, 2519
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
On EPA IRIS database

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