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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,2-difluoro-1,1,2,2-tetrachloro-

RTECS #

KI1420000

CAS #

76-12-0

Updated

September 201

Molecular Weight

203.82

Molecular Formula

C2Cl4F2

Synonyms

1,1,2,2-Tetrachloro-1,2-difluoroethane
1,1,2,2-Tetrachloro-1,2-difluoroethane (ACGIH:OSHA)
1,2-Difluoro-1,1,2,2-tetrachloroethane
CFC-112
Daiflon 112
Daiflon S2
Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-
F-112
Freon 112
Genetron 112
Halocarbon 112
R 112
Refrigerant 112
Ucon 112

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 100 mg/20S rinse mildAIHAAP 27,332,1966
skin /guinea pig 100%/24H open irritation test mildAIHAAP 27,332,1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 50 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		TLSMA6 75,241,1963
inhalation/mouse Lowest published lethal concentration: 40000 mg/m3/2HVCVGH* -,634,1990
inhalation/mouse lethal concentration (50 percent kill): 123000 mg/m3/2HVCVGH* -,634,1990
inhalation/rat lowest published toxic concentration: 84000 mg/m3Behavioral: General anestheticVCVGH* -,634,1990
inhalation/rat lethal concentration (50 percent kill): 125000 mg/m3/4HVCVGH* -,634,1990
inhalation/rat Lowest published lethal concentration: 258000 mg/m3/40MVCVGH* -,634,1990
inhalation/rat lethal concentration (50 percent kill): 2 pph/15MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression		HUTODJ 1,239,1982
oral/guinea pig Lethal dose: >10 gm/kgNTIS** OTS0520705
oral/mouse lethal dose (50 percent kill): 800 mg/kg85GMAT -,54,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/31D- intermittentLiver: Other changes

Blood: Luekopenia		AIHAAP 27,332,1966

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 500 ppm (4170 mg/m3)DTLVS* 3,249,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 500 ppm (4170 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (1690 mg/m3);KZW 1000 ppm (8450 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 500 ppm (4231 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (1665 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 500 ppm (4200 mg/m3), short term exposure limit 630 ppm (5300 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 500 ppm (4170 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 200 ppm (1700 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (1665 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 500 ppm (4170 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 500 ppm (4170 mg/m3);short term exposure limit 625 ppm (5210 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 500 ppm (4170 mg/m3), JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 1000 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (1690 mg/m3), KZG-week 400 ppm (3380 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 850 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 500 ppm (4170 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 500 ppm (4170 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE-airtime-weighted average 500 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 71447; Number of Industries 5; Total Number of Facilities 95; Number of Occupations 5; Total Number of Employees Exposed 1434; Total Number of Female Employees Exposed 191
National Occupational Hazard Survey 1974Hazard Code 71447; Number of Industries 8; Total Number of Facilities 451; Number of Occupations 7; Total Number of Employees Exposed 7803

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016
NTP Toxicity studies, RPT# TOX-45, October 2000

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