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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1-dichloro-

RTECS #

KI0175000

CAS #

75-34-3

Updated

September 201

Molecular Weight

98.96

Molecular Formula

C2H4Cl2

Synonyms

1,1-Dichloorethaan (Dutch)
1,1-Dichloraethan (German)
1,1-Dichlorethane
1,1-Dichloroethane
1,1-Dichloroethane (ACGIH:OSHA)
1,1-Dicloroetano (Italian)
Aethylidenchlorid (German)
Chlorinated hydrochloric ether
Chlorure d'ethylidene (French)
Cloruro di etilidene (Italian)
Ethylidene chloride (OSHA)
Ethylidene dichloride
NCI-C04535
RCRA waste number U076

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunction/Aspergillus nidulans2000 ppmMUREAV 201,401,1988
Unscheduled DNA Synthesisliver/rat13 mmol/LMUREAV 221,263,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 6000 ppm/7H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 28,452,1974

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 185 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors		NCITR* NCI-TR-66,1978
oral/mouse toxic dose: 1300 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors		NCITR* NCI-TR-66,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, liver Inhibitor Concentration (50 percent kill): 4.9 mmol/L/2HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 3,145,1989
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 3.12 mmol/L/2HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 3,145,1989
inhalation/mouse lowest published toxic concentration: 30000 mg/m3/2HBehavioral: General anestheticVCVGH* -,355,1990
inhalation/mouse Lowest published lethal concentration: 70000 mg/m3/2HVCVGH* -,355,1990
inhalation/rat lethal concentration (50 percent kill): 13000 ppm/4HNTIS** AD-A180-198
oral/rat lethal dose (50 percent kill): 725 mg/kgHYSAAV 32(3),349,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 240 gm/kg/12W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TOXID9 6,313,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAIHAAP 40(3),A46,1979
TOXICOLOGY REVIEWNTIS** PB82-182809
TOXICOLOGY REVIEWMUREAV 543,201,2003

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (320 mg/m3)DTLWS* 3,15,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (412 mg/m3),JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 100 ppm (400 mg/m3);KZW 400 ppm (1600 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (412 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (412 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 412 mg/m3 (100 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (410 mg/m3), short term exposure limit 250 ppm (1000 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (412 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (410 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 412 mg/m3, short term exposure limit 824 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (400 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (400 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (810 mg/m3), short term exposure limit 250 ppm (1010 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (810 mg/m3);short term exposure limit 250 ppm (1010 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (810 mg/m3); short term exposure limit 250 ppm (1010 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (405 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 50 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 100 ppm, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 100 ppm (412 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (400 mg/m3), KZG-week 200 ppm (800 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 50 ppm, short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 400 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (400 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (400 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (400 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (400 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1-DICHLOROETHANE-air10H time-weighted average 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24120; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 7; Total Number of Employees Exposed 1957; Total Number of Female Employees Exposed 272
National Occupational Hazard Survey 1974Hazard Code 24120; Number of Industries 7; Total Number of Facilities 143; Number of Occupations 9; Total Number of Employees Exposed 715

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180539/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse,ratNCITR* NCI-TR-66,1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
On EPA IRIS database

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