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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1'-oxybis-

RTECS #

KI5775000

CAS #

60-29-7

Updated

September 201

Molecular Weight

74.14

Molecular Formula

C4H10O

Synonyms

Aether
Anaesthetic ether
Anesthesia ether
Anesthetic ether
Diaethylaether (German)
Diethyl ether (DOT:OSHA)
Diethyl oxide
Dwuetylowy eter (Polish)
Etere etilico (Italian)
Ether
Ether ethylique (French)
Ethoxyethane
Ethyl ether
Ethyl ether (ACGIH:OSHA)
Oxyde d'ethyle (French)
RCRA waste number U117
Solvent ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 100 ppmJIHTAB 25,282,1943
eye /rabbit 100 mg moderateFEPRA7 35,729,1976
eye /rabbit 100 mg/24H moderateHPV225 -,-,2003
skin /guinea pig 50 mg/24H severeHPV225 -,-,2003
skin /rabbit 360 mg mildHPV225 -,-,2003
skin /rabbit 360 mg open irritation test mildUCDS** 4/5/1973

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionembryo/mouse2850 mg/LJJATDK 5,1,1985
DNA repair/Escherichia coli35670 µg/well/16HCBINA8 15,219,1976
other mutation test systemsfibroblast/hamster1 pphANESAV 43,21,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 76000 ppmHBAMAK 4,1294,1935
inhalation/Dog Lowest published lethal concentration: 208000 mg/m3/71MHPV225 -,-,2003
inhalation/Dog Lowest published lethal concentration: 235000 mg/m3HPV225 -,-,2003
inhalation/human lowest published toxic concentration: 200 ppmOlfaction: Other olfaction effectsJIHTAB 25,282,1943
inhalation/human lowest published toxic concentration: 600 mg/m3/3MLung, Thorax, or Respiration: CoughVCVGK* -,264,1994
inhalation/human lowest published toxic concentration: 100000 mg/m3/30MBehavioral: General anestheticVCVGK* -,264,1994
inhalation/man lowest published toxic concentration: 10000 ppmBehavioral: AnalgesiaHPV225 -,-,2003
inhalation/man lowest published toxic concentration: 30000 ppmBehavioral: General anestheticHPV225 -,-,2003
inhalation/man lowest published toxic concentration: 60000 ppmBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression		HPV225 -,-,2003
inhalation/man Lowest published lethal concentration: 103000 ppmBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression		HPV225 -,-,2003
inhalation/mouse lethal concentration (50 percent kill): 31300 ppm/90MHPV225 -,-,2003
inhalation/mouse lethal concentration (50 percent kill): 130000 mg/m3/3HHPV225 -,-,2003
inhalation/mouse lowest published toxic concentration: 99200 mg/m3Behavioral: ExcitementHPV225 -,-,2003
inhalation/mouse lowest published toxic concentration: 198000 mg/m3Behavioral: General anestheticHPV225 -,-,2003
inhalation/mouse Lowest published lethal concentration: 397000 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression		HPV225 -,-,2003
inhalation/mouse Lowest published lethal concentration: 90000 mg/m3/100MHPV225 -,-,2003
inhalation/mouse lowest published toxic concentration: 24434 ppm/30MBehavioral: Alteration of classical conditioningTXAPA9 193,9,2003
inhalation/mouse lowest published toxic concentration: 30000 ppm/30MBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning		TXAPA9 193,9,2003
inhalation/mouse lethal concentration (50 percent kill): 31000 ppm/30MENTOX* -,33,2005
inhalation/mouse lethal concentration (50 percent kill): 31000 ppm/30MBehavioral: Convulsions or effect on seizure thresholdJIDOAA 34,379,1985
inhalation/rabbit Lowest published lethal concentration: 106000 ppmHBAMAK 4,1294,1935
inhalation/rabbit lowest published toxic concentration: 10000 mg/m3/40MPeripheral Nerve and Sensation: Recording from peripheral motor nerveVCVGK* -,264,1994
inhalation/rabbit Lowest published lethal concentration: 329000 mg/m3HPV225 -,-,2003
inhalation/rat lowest published toxic concentration: 7 pphNutritional and Gross Metabolic: Body temperature decreaseFATOAO 47,21,1984
inhalation/rat Lowest published lethal concentration: 32000 ppm/4HAIHAAP 23,95,1962
intraperitoneal/guinea pig lowest published lethal dose: 2 gm/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesAIHAAP 35,21,1974
intraperitoneal/guinea pig lowest published lethal dose: 2000 mg/kgHPV225 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 2.4 gm/kgENTOX* -,33,2005
intravenous/mouse lethal dose (50 percent kill): 996 mg/kgHPV225 -,-,2003
oral/human lowest published lethal dose: 273 mg/kgHPV225 -,-,2003
oral/man lowest published lethal dose: 260 mg/kg85DCAI 2,73,1970
oral/mouse lethal dose (50 percent kill): 1760 mg/kgVCVGK* -,264,1994
oral/rat lethal dose (50 percent kill): 1211 mg/kgHPV225 -,-,2003
skin/rabbit lethal dose (50 percent kill): >20 mL/kgAIHAAP 23,95,1962
subcutaneous/frog lowest published lethal dose: 24 gm/kgHBAMAK 4,1295,1935
subcutaneous/mouse lowest published lethal dose: 8 mg/kgHBAMAK 4,1295,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 1 pph/24H/5W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		ANESAV 42,408,1975
inhalation/guinea pig lowest published toxic concentration: 10000 ppm/35D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV225 -,-,2003
inhalation/mouse lowest published toxic concentration: 1000 ppm/24H/5W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ANESAV 42,408,1975
inhalation/mouse lowest published toxic concentration: 1000 ppm/35D- intermittentLiver: Changes in liver weightHPV225 -,-,2003
inhalation/mouse lowest published toxic concentration: 10000 ppm/35D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV225 -,-,2003
oral/guinea pig lowest published toxic dose: 7600 mg/kg/152D- intermittentGastrointestinal: GastritisVCVGK* -,265,1994
oral/guinea pig lowest published toxic dose: 760 mg/kg/152D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,265,1994
oral/rat lowest published toxic dose: 7600 mg/kg/152D- intermittentGastrointestinal: GastritisVCVGK* -,265,1994
oral/rat lowest published toxic dose: 760 mg/kg/152D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,265,1994
oral/rat lowest published toxic dose: 180000 mg/kg/90D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV225 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 400 ppm;short term exposure limit 500 ppmDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMSUDL 7,93,1987
TOXICOLOGY REVIEWTOLED5 140-141,249,2003
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,33,2005
TOXICOLOGY REVIEWHUTOX* -,493,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNTAPM* -,727,1995

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 400 ppm (1200 mg/m3)DTLVS* 3,106,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 400 ppm (1210 mg/m3), short term exposure limit 500 ppm (1520 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 100 ppm (300 mg/m3);KZW 200 ppm (600 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm(308 mg/m3), short term exposure limit 200 ppm(616 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (303 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 308 mg/m3 (100 ppm);short term exposure limit 616 mg/m3 (200 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (310 mg/m3), short term exposure limit 200 ppm (620 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (308 mg/m3), VLE 200 ppm (616 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 400 ppm (1200 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 308 mg/m3, short term exposure limit 616 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (308 mg/m3), short term exposure limit 200 ppm (616 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 400 ppm (1200 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 400 ppm (1200 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 400 ppm (1200 mg/m3);short term exposure limit 500 ppm (1500 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 400 ppm (1210 mg/m3); short term exposure limit 500 ppm (1520 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 200 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 400 ppm; short term exposure limit 500 ppm, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1500 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 300 mg/m3, short term exposure limit 900 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 300 ppm (900 mg/m3);short term exposure limit 400 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 400 ppm (1200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 308 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (310 mg/m3);short term exposure limit 200 ppm (620 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 400 ppm (1200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 400 ppm (1200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 400 ppm (1200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 400 ppm (1200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 32590; Number of Industries 104; Total Number of Facilities 21212; Number of Occupations 78; Total Number of Employees Exposed 272746; Total Number of Female Employees Exposed 35683
National Occupational Hazard Survey 1974Hazard Code 32590; Number of Industries 112; Total Number of Facilities 17282; Number of Occupations 82; Total Number of Employees Exposed 161572

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl ether, 1610
On EPA IRIS database

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