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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, pentachloro-

RTECS #

KI6300000

CAS #

76-01-7

Updated

July 2013

Molecular Weight

202.28

Molecular Formula

C2HCl5

Synonyms

Ethane pentachloride
NCI-C53894
Pentachloorethaan (Dutch)
Pentachloraethan (German)
Pentachlorethane (French)
Pentachloroethane
Pentacloroetano (Italian)
Pentalin
RCRA waste number U184

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster80 mg/LMUREAV 369,243,1996
mutation in mammalian somatic cellslymphocyte/mouse70 mg/LEMMUEG 12,85,1988
mutation in microorganisms/Saccharomyes cerevisiae2500 µmol/L (+enzymatic activation step)TCMUD8 9,349,1989
other mutation test systemsoral/mouse500 mg/kgMUREAV 343,157,1995
other mutation test systems/Escherichia coli25814 µmol/LEMMUEG 19,98,1992
sex chromosome loss and nondisjunctionlung/human80 mg/LMUREAV 369,243,1996
sister chromatid exchangeovary/hamster100 mg/LSCIEAS 236,933,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 71750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		NTIS** PB83-206748
oral/rat lowest published toxic dose: 108150 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTIS** PB83-206748

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 17 mg/m3Behavioral: General anestheticVCVGH* -,390,1990
inhalation/mouse lowest published toxic concentration: 7500 mg/m3/2HBehavioral: General anestheticVCVGH* -,307,1990
inhalation/mouse Lowest published lethal concentration: 35000 mg/m3/2HVCVGH* -,390,1990
inhalation/rat lethal concentration (50 percent kill): 4238 ppm/2H85JCAE -,97,1986
intravenous/Dog lowest published lethal dose: 100 mg/kgQJPPAL 7,205,1934
oral/Dog lowest published lethal dose: 500 mg/kgBehavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration		AJHYA2 16,325,1932
oral/rat lethal dose (50 percent kill): 920 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Liver: Other changes		SRTCAC 36(1-4),10,1989
subcutaneous/rabbit lowest published lethal dose: 700 mg/kgQJPPAL 7,205,1934

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982
oral/mouse lowest published toxic dose: 14 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982
oral/rat lowest published toxic dose: 7 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-232,1982

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1519,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1519,1999
TOXICOLOGY REVIEWAIHAAP 40(3),A46,1979
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWMUTAEX 14,271,1999
TOXICOLOGY REVIEWMUREAV 628,67,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (40 mg/m3);KZW 20 ppm (160 mg/m3), 2007
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (40 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (42 mg/m3), short term exposure limit 10 ppm (84 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (42 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (40 mg/m3), skin, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (40 mg/m3), KZG-week 10 ppm (80 mg/m3), carc 3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (40 mg/m3), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROETHANE-airHandle with cautionNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6173; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 232; Total Number of Female Employees Exposed 3

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NIOSH Analytical Method, 1994: Pentachloroethane, 2517
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NTP Toxicity studies, RPT# TOX-45, October 2000
On EPA IRIS database

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