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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1,1,2-tetrachloro-

RTECS #

KI8450000

CAS #

630-20-6

Updated

July 2011

Molecular Weight

167.84

Molecular Formula

C2H2Cl4

Synonyms

1,1,1,2-Tetrachloroethane
NCI-C52459
RCRA waste number U208

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAMPMAR 35,593,1974
skin /rabbit 500 mg/24HAMPMAR 35,593,1974

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Aspergillus nidulans250 ppmMUREAV 201,401,1988
mutation in mammalian somatic cellslymphocyte/mouse200 mg/LEMMUEG 12,85,1988
mutation in microorganismslymphocyte/mouse200 mg/L (+enzymatic activation step)SCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+/-enzymatic activation step)TECSDY 15,101,1987
other mutation test systemsoral/mouse1 gm/kgMUREAV 343,157,1995
sex chromosome loss and nondisjunction/Aspergillus nidulans125 ppmMUREAV 201,401,1988
sex chromosome loss and nondisjunctionlung/human100 mg/LMUREAV 369,243,1996
sister chromatid exchangeovary/hamster158 mg/LSCIEAS 236,933,1987
specific locus testovary/hamster0.65 gm/L/24HMUREAV 602,14,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 128750 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		NTIS** PB83-218206
oral/rat lowest published toxic dose: 128750 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		NTIS** PB83-218206
oral/rat lowest published toxic dose: 64375 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors		NTIS** PB83-218206

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, liver Inhibitor Concentration (50 percent kill): 0.7 mmol/L/2HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 3,145,1989
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 1.4 mmol/L/2HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 3,145,1989
inhalation/rabbit lethal concentration (50 percent kill): 2800 ppm/4HGastrointestinal: Hypermotility, diarrheaAMPMAR 35,593,1974
inhalation/rabbit lowest published toxic concentration: 2000 ppmLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough		VCVGH* -,384,1990
inhalation/rabbit lowest published toxic concentration: 2500 ppmLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Hemorrhage		VCVGH* -,384,1990
inhalation/rabbit lethal concentration (50 percent kill): 2800 mg/m3/4HVCVGH* -,383,1990
inhalation/rat lowest published toxic concentration: 2000 ppmLung, Thorax, or Respiration: CoughVCVGH* -,384,1990
inhalation/rat lowest published toxic concentration: 3000 ppmLung, Thorax, or Respiration: Acute pulmonary edemaVCVGH* -,384,1990
inhalation/rat lowest published toxic concentration: 4000 ppmLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes		VCVGH* -,384,1990
inhalation/rat lethal concentration (50 percent kill): 2100 mg/m3/4HVCVGH* -,383,1990
inhalation/rat lethal concentration (50 percent kill): 2100 ppm/4HGastrointestinal: Hypermotility, diarrheaAMPMAR 35,593,1974
intraperitoneal/mouse lethal dose (50 percent kill): 1275 mg/kgSAIGBL 8,371,1966
oral/guinea pig lowest published toxic dose: 600 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonalVCVGH* -,384,1990
oral/mouse lowest published toxic dose: 1000 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonalVCVGH* -,384,1990
oral/mouse lethal dose (50 percent kill): 1500 mg/kgVCVGH* -,383,1990
oral/rat lethal dose (50 percent kill): 670 mg/kgVCVGH* -,383,1990
skin/rabbit lethal dose (50 percent kill): 20 mg/kgVCVGH* -,383,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 16 gm/kg/40D- intermittentBehavioral: SleepSAIGBL 8,371,1966
intraperitoneal/mouse lowest published toxic dose: 2400 mg/kg/3D- intermittentBehavioral: Sleep

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		SAIGBL 8,371,1966
oral/mouse lowest published toxic dose: 14 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-237,1982
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-237,1982
oral/rat lowest published toxic dose: 128750 mg/kg/103W- intermittentBrain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent		NTIS** PB83-218206
oral/rat lowest published toxic dose: 7 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-237,1982

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,87,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1133,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,87,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1133,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1133,1999
TOXICOLOGY REVIEWAIHAAP 40(3),A46,1979
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWMUREAV 628,67,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLOROETHANE-airHandle with cautionNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NTP Toxicity studies, RPT# TOX-45, October 2000
On EPA IRIS database

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