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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethane, 1,1,2-trichloro-1,2,2-trifluoro-

RTECS #

KJ4000000

CAS #

76-13-1

Updated

September 201

Molecular Weight

187.37

Molecular Formula

C2Cl3F3

Synonyms

1,1,2-Trichloro-1,2,2-trifluoroethane
1,1,2-Trichloro-1,2,2-trifluoroethane (ACGIH:OSHA)
1,1,2-Trichlorotrifluoroethane
1,1,2-Trifluoro-1,2,2-trichloroethane
1,1,2-Trifluorotrichloroethane
1,2,2-Trichlorotrifluoroethane
Arcton 63
Arklone P
Asahifron 113
CFC-113
Chlorofluorethane
Chlorofluorocarbon 113
Daiflon S 3
F 113
FC 113
Fluorocarbon 113
Freon 113
Freon 113, commercial grade
Freon 113, contaminated
Freon 113, specially purified
Freon 113TR-T
Freon F113
Freon TF
Freon-TF
Frigen 113
Frigen 113 TR-T
Frigen 113a
Frigen 113TR
Frigen 113TR-N
Genetron 113
Halocarbon 113
Isceon 113
Kaiser chemicals 11
Khladon 113
Ledon 113
R 113
R 113 (Halocarbon)
Racon 113
Refrigerant 113
Refrigerant R 113

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test mildUCDS** 7/10/1970
skin /rabbit 500 mg/24H mild85JCAE -,137,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 20 ppm (8-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Physical		EPASR* #86-890000920S
oral/rabbit 5 gm/kg (8D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death		NTIS** OTS0571230

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): >12 pph/2HAMPMAR 29,381,1968
inhalation/guinea pig Lowest published lethal concentration: 4 pph/60MLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage		TJIDAH 95,1283,1980
inhalation/human lowest published toxic concentration: 2500 ppm/90MBehavioral: Change in psychophysiological testsAIHAAP 28,43,1967
inhalation/mouse Lowest published lethal concentration: 230000 mg/m3/2HVCVGH* -,636,1990
inhalation/mouse lowest published toxic concentration: 393000 mg/m3/1HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: General anesthetic		VCVGH* -,636,1990
inhalation/mouse lethal concentration (50 percent kill): 260 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		TLSMA6 75,241,1963
inhalation/rabbit lethal concentration (50 percent kill): 59500 ppm/2HEye: Other eye effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation		NTIS** OTS0520343
inhalation/rabbit Lowest published lethal concentration: 55120 ppm/2HEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands		EPASR* #86-890000904S
inhalation/rabbit lethal concentration (50 percent kill): 59500 ppm/2HVascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory obstruction		EPASR* #86-890000904S
inhalation/rat Lowest published lethal concentration: 57500 ppm/4HBehavioral: Tremor

Behavioral: Excitement		EPASR* #86-890000906S
inhalation/rat Lowest published lethal concentration: 37000 ppm/4HBehavioral: Tremor

Behavioral: Ataxia		EPASR* #86-890000902S
inhalation/rat lethal concentration (50 percent kill): 38000 ppm/4HEPASR* #86-890000902S
inhalation/rat Lowest published lethal concentration: 786000 mg/m3/4HVCVGH* -,636,1990
inhalation/rat lethal concentration (50 percent kill): 38500 ppm/4HBehavioral: General anesthetic

Behavioral: Excitement

Behavioral: Ataxia		NTIS** OTS0520341
intraperitoneal/mouse lowest published toxic dose: 23200 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins		ENVRAL 45,101,1988
intravenous/mouse lethal dose (50 percent kill): 9 gm/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Altered sleep time (including change in righting reflex)

Skin: After systemic exposure: Dermatitis, other		NTIS** OTS0520355
oral/guinea pig Lethal dose: >10 gm/kgNTIS** OTS0520705
oral/rabbit lowest published lethal dose: 17 gm/kgAIHAAP 29,521,1968
oral/rat lethal dose (50 percent kill): 43 gm/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair		JMCMAR 7,378,1964
oral/rat lethal dose (50 percent kill): 43 gm/kgBehavioral: General anestheticVCVGH* -,636,1990
skin/rabbit Lethal dose: >11 gm/kgAIHAAP 29,521,1968
unreported route/mouse lethal dose (50 percent kill): 40 gm/kgUSXXAM #4164653

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 70000 mg/m3/4H/16W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases		VCVGH* -,636,1990
inhalation/human lowest published toxic concentration: 4300 mg/m3/5D- intermittentBrain and Coverings: Recordings from specific areas of CNSVCVGH* -,637,1990
inhalation/human lowest published toxic concentration: 178 mg/m3/10Y- intermittentBehavioral: HeadacheVCVGH* -,637,1990
inhalation/rat lowest published toxic concentration: 20 pph/6H/2Y- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 11,68,1988
inhalation/rat lowest published toxic concentration: 2000 ppm/6H/2W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		TXCYAC 18,17,1980
inhalation/rat lowest published toxic concentration: 17500 ppm/6H/13W - intermittentLung, Thorax, or Respiration: Changes in lung weightEPASR* #86-890000892S
inhalation/rat lowest published toxic concentration: 20000 ppm/6H/13W - intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight		EPASR* #86-890000892S
multiple/guinea pig lowest published toxic concentration: 60 mL/kg/3W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TJIDAH 95,1283,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppm;short term exposure limit 1250 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAZMAE 18,365,1974
TOXICOLOGY REVIEWAIHAAP 29,521,1968
TOXICOLOGY REVIEWENTOX* -,384,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (7600 mg/m3)DTLVS* 3,267,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (3800 mg/m3);KZW 1000 ppm (7600 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (7781 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 1250 ppm (9729 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (3800 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (7800 mg/m3), short term exposure limit 1300 ppm (10000 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (7600 mg/m3), VLE 1250 ppm (9500 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (3900 mg/m3), 2011
Occupational Exposure Limit-HUNGARYProhibited in Hungary, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (3800 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 500 ppm (3800 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm (9500 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (1600 mg/m3);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (7665 mg/m3); short term exposure limit 1250 ppm (9581 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5000 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (4000 mg/m3);short term exposure limit 750 ppm (6000 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (3800 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1170 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (7600 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (7600 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (7600 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (7600 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 1000 ppm;short term exposure limit 1250 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 74010; Number of Industries 119; Total Number of Facilities 12471; Number of Occupations 103; Total Number of Employees Exposed 250773; Total Number of Female Employees Exposed 79790
National Occupational Hazard Survey 1974Hazard Code 74010; Number of Industries 175; Total Number of Facilities 19387; Number of Occupations 103; Total Number of Employees Exposed 282795

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2-Trichloro-1,2,2-trifluoroethane, 1020
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
On EPA IRIS database
OSHA ANALYTICAL METHOD #113

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