Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-butoxy-
RTECS #
KJ8575000CAS #
111-76-2Updated
September 201Molecular Weight
118.20Molecular Formula
C6H14O2Synonyms
2-Butossi-etanolo (Italian)2-Butoxy-1-ethanol
2-Butoxy-aethanol (German)
2-Butoxyethanol
2-Butoxyethanol (ACGIH:OSHA)
3-Oxa-1-heptanol
BUCS
Butoksyetylowy alkohol (Polish)
Butoxyethanol
Butyl cellosolve
Butyl cellosolve (OSHA)
Butyl oxitol
Butylcelosolv (Czech)
Butylglycol (French,German)
Dowanol EB
Ektasolve EB
Ethylene glycol monobutyl ether
Ethylene glycol n-butyl ether
Ethylene glycol, monobutyl ether
Gafcol EB
Glycol butyl ether
Glycol ether EB
Glycol monobutyl ether
Jeffersol EB
Monobutyl ether of ethylene glycol
Monobutyl glycol ether
n-Butoxyethanol
O-Butyl ethylene glycol
Poly-Solv EB
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 100 mg/24H | moderate | 85JCAE -,629,1986 |
| skin /rabbit | 500 mg open irritation test | mild | UCDS** |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | unreported route/mouse | 3150 mg/kg/7D | TOXID9 66,306,2002 |
| mutation in microorganisms | /Salmonella typhimurium | 19 µmol/plate (-enzymatic activation step) | MUREAV 341,281,1995 |
| Unscheduled DNA Synthesis | unreported route/mouse | 1575 mg/kg/7D | TOXID9 66,306,2002 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 483 mg/m3/6H (6-15D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,167,1994 |
| inhalation/rabbit | 483 mg/m3/6H (6-15D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,167,1994 |
| inhalation/rat | 200 ppm/6H (6-15D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | EVHPAZ 57,47,1984 |
| inhalation/rat | 25 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | EVHPAZ 57,47,1984 |
| inhalation/rat | 12 mg/kg/4H (1-19D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAVUAI 21,30,1989 |
| inhalation/rat | 200 ppm/6H (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTIS** OTS0571237 |
| inhalation/rabbit | 200 ppm/6H (6-18D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | EVHPAZ 57,47,1984 |
| inhalation/rabbit | 100 ppm/6H (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | EVHPAZ 57,47,1984 |
| oral/mouse | 9440 mg/kg (7-14D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | EVHPAZ 57,141,1984 |
| oral/rat | 6279 mg/kg (13W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTPTR* NIH-93-3349 |
| oral/mouse | 9440 mg/kg (7-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | EVHPAZ 57,141,1984 |
| oral/mouse | 7 gm/kg (8-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TCMUD8 7,55,1987 |
| oral/mouse | 9440 mg/kg (6-13D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TCMUD8 7,29,1987 |
| oral/mouse | 25.2 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85226827 |
| oral/mouse | 47.25 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB85226827 |
| oral/mouse | 0.72 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85226827 |
| oral/mouse | 0.72 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB85226827 |
| oral/mouse | 198.45 gm/kg (21W prior to copulation) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85226827 |
| oral/rat | 600 mg/kg (9-11D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | NTIS** #PB89-165849 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 250 ppm/6H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTPTR* NTP-TR-484,2000 |
| inhalation/mouse | lowest published toxic concentration: 15600 mg/kg/104W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB#2000-105865 |
| inhalation/mouse | lowest published toxic concentration: 15600 mg/kg/104W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NTIS** PB#2000-105865 |
| inhalation/rat | lowest published toxic concentration: 3250 mg/kg/104W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Adrenal cortex tumors | NTIS** PB#2000-105865 |
| inhalation/rat | lowest published toxic concentration: 125 ppm/6H/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors | NTPTR* NTP-TR-484,2000 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 12.5 mmol/L/48H | Reproductive: Other effects to embryo or fetus | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 25 mmol/L/48H | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 12.5 mmol/L/48H | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Other developmental abnormalities | TIVIEQ 7,777,1993 |
| inhalation/guinea pig | Lethal concentration: >633 ppm/1H | NTIS** OTS0572613 | |
| inhalation/human | lowest published toxic concentration: 195 ppm/8H | Gastrointestinal: Nausea or vomiting | AMIHAB 14,114,1956 |
| inhalation/human | lowest published toxic concentration: 100 ppm | Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes | NPIRI* 1,50,1974 |
| inhalation/human | lowest published toxic concentration: 1500 mg/m3 | Eye: Conjunctiva irritation Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,166,1984 |
| inhalation/mouse | lethal concentration (50 percent kill): 3380 mg/m3/7H | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| inhalation/mouse | lethal concentration (50 percent kill): 700 ppm/7H | Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria | JIHTAB 25,157,1943 |
| inhalation/rat | lethal concentration (50 percent kill): 450 ppm/4H | Behavioral: Ataxia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 68,405,1983 |
| inhalation/rat | lethal concentration (50 percent kill): 2900 mg/m3/7H | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| inhalation/rat | Lowest published lethal concentration: 1800 mg/m3/7H | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| intraperitoneal/mammal (species unspecified) | lowest published toxic dose: 100 mg/kg | Endocrine: Change in gonadotropins | VCVGK* -,166,1984 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 536 mg/kg | SCCUR* -,2,1961 | |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 220 mg/kg | 85GMAT -,67,1982 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 220 mg/kg | 85GMAT -,67,1982 | |
| intravenous/mouse | lethal dose (50 percent kill): 1130 mg/kg | AMIHAB 14,114,1956 | |
| intravenous/rabbit | lethal dose (50 percent kill): 252 mg/kg | AMIHAB 14,114,1956 | |
| intravenous/rat | lethal dose (50 percent kill): 307 mg/kg | AMIHAB 14,114,1956 | |
| oral/guinea pig | lethal dose (50 percent kill): 1200 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/human | lowest published lethal dose: 143 mg/kg | VCVGK* -,166,1984 | |
| oral/man | lowest published toxic dose: 132 mg/kg | Behavioral: Sleep Kidney, Ureter, and Bladder: Hematuria Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | JTCTDW 41,57,2003 |
| oral/mouse | lethal dose (50 percent kill): 1167 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| oral/mouse | lethal dose (50 percent kill): 1230 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair | AMIHAB 14,114,1956 |
| oral/rabbit | lethal dose (50 percent kill): 320 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| oral/rabbit | lethal dose (50 percent kill): 300 mg/kg | YKYUA6 32,1241,1981 | |
| oral/rat | lethal dose (50 percent kill): 917 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other hemolysis with or without anemia | VCVGK* -,166,1984 |
| oral/rat | lethal dose (90 percent kill): 1500 mg/kg | Kidney, Ureter, and Bladder: Hematuria Blood: Other changes | TXAPA9 225,102,2007 |
| oral/rat | lowest published lethal dose: 1500 mg/kg | Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance | TOXID9 90,61,2006 |
| oral/rat | lethal dose (50 percent kill): 250 mg/kg | ENTOX* -,290,2005 | |
| oral/rat | lowest published toxic dose: 500 mg/kg | Blood: Other hemolysis with or without anemia | TOXID9 44,172,2005 |
| oral/woman | lowest published toxic dose: 600 mg/kg | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | HUTODJ 7,187,1988 |
| oral/woman | lowest published toxic dose: 7813 µL/kg | Behavioral: Coma Vascular: BP lowering not characterized in autonomic section Nutritional and Gross Metabolic: Changes in: Metabolic acidosis | HUTODJ 8,243,1989 |
| skin/guinea pig | lethal dose (50 percent kill): 230 µL/kg | TXAPA9 7,559,1965 | |
| skin/rabbit | lethal dose (50 percent kill): 220 mg/kg | DOWCC* MSD-46 | |
| skin/rabbit | lowest published toxic dose: 0.56 mL/kg/1H | Blood: Other hemolysis with or without anemia Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,167,1984 |
| subcutaneous/mouse | lowest published lethal dose: 500 mg/kg | JPETAB 42,355,1931 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 1500 mg/kg | GISAAA 51(5),61,1986 | |
| unreported route/mouse | lethal dose (50 percent kill): 1050 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes | GISAAA 41(11),7,1976 |
| unreported route/rat | lethal dose (50 percent kill): 917 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes | GISAAA 41(11),7,1976 |
| unreported route/rat | lowest published toxic dose: 250 mg/kg | Blood: Change in clotting factors | TOXID9 44,172,2005 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 415 ppm/7H/12W- intermittent | Blood: Microcytosis with or without anemia Kidney, Ureter, and Bladder: Other changes in urine composition | JIHTAB 25,409,1943 |
| inhalation/Dog | lowest published toxic concentration: 385 ppm/7H/28D- intermittent | Blood: Other changes Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 14,114,1956 |
| inhalation/Dog | lowest published toxic concentration: 2000 mg/m3/7H/12W- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,167,1994 |
| inhalation/guinea pig | lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,167,1994 |
| inhalation/guinea pig | lowest published toxic concentration: 376 ppm/7H/30D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHAB 14,114,1956 |
| inhalation/monkey | lowest published toxic concentration: 500 mg/m3/7H/12W- intermittent | Blood: Normocytic anemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,167,1994 |
| inhalation/mouse | lowest published toxic concentration: 396 ppm/7H/30D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Hematuria Blood: Other changes | AMIHAB 14,114,1956 |
| inhalation/mouse | lowest published toxic concentration: 401 ppm/7H/90D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Hematuria Blood: Other changes | AMIHAB 14,114,1956 |
| inhalation/rat | lowest published toxic concentration: 1540 mg/m3/7H/5W- intermittent | Blood: Changes in erythrocyte (RBC) count | JIHTAB 25,374,1943 |
| inhalation/rat | lowest published toxic concentration: 432 ppm/7H/30D- intermittent | Kidney, Ureter, and Bladder: Hematuria Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHAB 14,114,1956 |
| inhalation/rat | lowest published toxic concentration: 245 ppm/6H/9D- intermittent | Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count | TXAPA9 68,405,1983 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/24H/13W- continuous | Endocrine: Hypoglycemia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 41(11),7,1976 |
| inhalation/rat | lowest published toxic concentration: 421 mg/m3/13W- intermittent | Blood: Other hemolysis with or without anemia | VCVGK* -,167,1994 |
| inhalation/rat | lowest published toxic concentration: 516 mg/m3/30D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,167,1994 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/90D- continuous | Endocrine: Hypoglycemia Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,167,1994 |
| inhalation/rat | lowest published toxic concentration: 900 mg/m3/4H/25D- intermittent | Brain and Coverings: Increased intracranial pressure Kidney, Ureter, and Bladder: Changes primarily in glomeruli Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,167,1994 |
| oral/mouse | lowest published toxic dose: 198.45 gm/kg/21W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB85226827 |
| oral/mouse | lowest published toxic dose: 37.8 gm/kg/4W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB85226827 |
| oral/mouse | lowest published toxic dose: 20.16 gm/kg/4W- continuous | Behavioral: Fluid intake | NTIS** #PB85226827 |
| oral/mouse | lowest published toxic dose: 198.45 gm/kg/21W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB85226827 |
| oral/mouse | lowest published toxic dose: 198.45 gm/kg/21W- continuous | Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB85226827 |
| oral/mouse | lowest published toxic dose: 5180 mg/kg/2W- continuous | Endocrine: Changes in thymus weight | NTPTR* NIH-93-3349 |
| oral/mouse | lowest published toxic dose: 9440 mg/kg/8D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,141,1984 |
| oral/mouse | lowest published toxic dose: 5 gm/kg/10D- intermittent | Gastrointestinal: Gastritis | TXCYAC 180,257,2002 |
| oral/mouse | lowest published toxic dose: 2250 mg/kg/7D- intermittent | Liver: Changes in liver weight Blood: Other hemolysis with or without anemia Blood: Changes in spleen | TOSCF2 70,252,2002 |
| oral/mouse | lowest published toxic dose: 51429 mg/kg/90D- intermittent | Liver: Other changes Blood: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency | TOXID9 60,287,2001 |
| oral/mouse | lowest published toxic dose: 51429 mg/kg/90D- intermittent | Biochemical: Metabolism (intermediary): Other | TOXID9 60,287,2001 |
| oral/mouse | lowest published toxic dose: 6300 mg/kg/7D- intermittent | Liver: Other changes | TOXID9 -,333,2009 |
| oral/mouse | lowest published toxic dose: 2250 mg/kg/7D- intermittent | Liver: Other changes Endocrine: Changes in spleen weight | TXCYAC 270,131,2010 |
| oral/mouse | lowest published toxic dose: 4500 mg/kg/7D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Other hemolysis with or without anemia | TXCYAC 270,131,2010 |
| oral/rat | lowest published toxic dose: 46.5 mg/kg/60D- continuous | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,167,1994 |
| oral/rat | lowest published toxic dose: 500 mg/kg/2D- intermittent | Blood: Other changes | ARTODN 77,465,2003 |
| oral/rat | lowest published toxic dose: 500 mg/kg/4D- intermittent | Vascular: Thromobosis distant from injection site Blood: Other hemolysis with or without anemia | ETPAEK 58,311,2007 |
| oral/rat | lowest published toxic dose: 3500 mg/kg/7D- intermittent | Blood: Other changes | TXAPA9 230,338,2008 |
| oral/rat | lowest published toxic dose: 1575 mg/kg/7D- intermittent | Liver: Other changes Blood: Other hemolysis with or without anemia Blood: Changes in spleen | TOSCF2 70,252,2002 |
| oral/rat | lowest published toxic dose: 14000 mg/kg/4W- intermittent | Endocrine: Changes in thymus weight Blood: Changes in bone marrow not included in above Related to Chronic Data: Changes in ovarian weight | VCVGK* -,166,1994 |
| oral/rat | lowest published toxic dose: 2170 mg/kg/4W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Changes in erythrocyte (RBC) count | VCVGK* -,166,1994 |
| oral/rat | lowest published toxic dose: 13290 mg/kg/6W- intermittent | Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FAATDF 6,349,1986 |
| oral/rat | lowest published toxic dose: 139 gm/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHAB 14,114,1956 |
| oral/rat | lowest published toxic dose: 9324 mg/m3/21D- continuous | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 16,830,1991 |
| oral/rat | lowest published toxic dose: 1500 mg/kg/12D- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Other changes Blood: Changes in erythrocyte (RBC) count | TXAPA9 112,198,1992 |
| oral/rat | lowest published toxic dose: 300 mg/kg/3D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight | NTIS** #PB89-165849 |
| oral/rat | lowest published toxic dose: 300 mg/kg/3D- intermittent | Blood: Normocytic anemia Blood: Other hemolysis with or without anemia | NTIS** #PB89-165849 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/4D- intermittent | Cardiac: Cardiomyopathy including infarction Vascular: Thromobosis distant from injection site Blood: Changes in bone marrow not included in above | TOXID9 72,30,2003 |
| skin/mouse | lowest published toxic dose: 6000 mg/kg/4D- continuous | Endocrine: Changes in spleen weight Blood: Changes in spleen | IJTOFN 20,383,2001 |
| skin/mouse | lowest published toxic dose: 2000 mg/kg/4D- continuous | Immunological Including Allergic: Decrease in cellular immune response | IJTOFN 20,383,2001 |
| skin/mouse | lowest published toxic dose: 6 gm/kg/4D- intermittent | Endocrine: Changes in spleen weight Blood: Changes in spleen Immunological Including Allergic: Decreased immune response | TOXID9 42,209,1998 |
| skin/rabbit | lowest published toxic dose: 6.3 mL/kg/2W- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,167,1994 |
| skin/rabbit | lowest published toxic dose: 4500 µL/kg/9D- intermittent | Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count | NTIS** OTS0516797 |
| skin/rat | lowest published toxic dose: 17.5 mL/kg/10D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,167,1994 |
| subcutaneous/rat | lowest published toxic dose: 2955 mg/kg/4W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 82,125,2008 |
| unreported route/rat | lowest published toxic dose: 1000 mg/kg/4D- intermittent | Blood: Change in clotting factors Musculoskeletal: Other changes | TOXID9 44,172,2005 |
| unreported route/rat | lowest published toxic dose: 500 mg/kg/4D- intermittent | Blood: Other changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 90,341,2006 |
| unreported route/rat | lowest published toxic dose: 1000 mg/kg/4D- intermittent | Blood: Other hemolysis with or without anemia Blood: Other changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 90,341,2006 |
| unreported route/rat | lowest published toxic dose: 750 mg/kg/3D- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) Eye: Changes in circulation | TOXID9 72,311,2003 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review: Group 3 | IMEMDT 88,400,2006 |
| TOXICOLOGY REVIEW | FAATDF 13,747,1989 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | EMMUEG 39,69,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,290,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,451,2005 | |
| TOXICOLOGY REVIEW | IJTOFN 24,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | TOPADD 33,517,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,385,2004 | |
| TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
| TOXICOLOGY REVIEW | MUREAV 566,49,2004 | |
| TOXICOLOGY REVIEW | HUTOX* -,623,1996 | |
| TOXICOLOGY REVIEW | HUTOX* -,649,1996 | |
| TOXICOLOGY REVIEW | TOLED5 180,100,2008 | |
| TOXICOLOGY REVIEW | MUREAV 751,49,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,241,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 50 ppm (240 mg/m3) (skin) | DTLVS* 3,29,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 20 ppm (96.9 mg/m3), short term exposure limit 50 ppm (242 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 20 ppm (98 mg/m3);KZW 40 ppm (200 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 20 ppm (98 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 50 ppm (246 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 20 ppm (98 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 98 mg/m3 (20 ppm);short term exposure limit 246 mg/m3 (50 ppm), skin, JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 20 ppm (98 mg/m3), short term exposure limit 50 ppm (250 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 2 ppm (9.8 mg/m3), VLE 30 ppm (147.6 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 10 ppm (49 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 98 mg/m3, short term exposure limit 246 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 20 ppm (100 mg/m3), short term exposure limit 50 ppm (246 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 25 ppm (120 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 26 ppm (120 mg/m3);short term exposure limit 75 ppm (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 25 ppm (121 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 20 ppm (100 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 20 ppm (97 mg/m3); short term exposure limit 50 ppm (242 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 360 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 10 ppm (50 mg/m3);short term exposure limit 20 ppm (100 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 ppm (49 mg/m3), KZG-week 20 ppm (98 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 100 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 50 ppm (240 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 50 ppm (240 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 25 ppm (123 mg/m3);short term exposure limit 50 ppm (246 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 50 ppm (240 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 50 ppm (240 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 50 ppm (240 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 50 ppm (240 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL MONOBUTYL ETHER-air | 10H time-weighted average 5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 29930; Number of Industries 402; Total Number of Facilities 130413; Number of Occupations 239; Total Number of Employees Exposed 2139297; Total Number of Female Employees Exposed 585932 | |
| National Occupational Hazard Survey 1974 | Hazard Code 29930; Number of Industries 398; Total Number of Facilities 141929; Number of Occupations 199; Total Number of Employees Exposed 1547951 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division