Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-isopropoxy-
RTECS #
KL5075000CAS #
109-59-1Updated
September 201Molecular Weight
104.17Molecular Formula
C5H12O2Synonyms
2-Isopropoxyethanol2-Isopropoxyethanol (ACGIH)
beta-Hydroxyethyl isopropyl ether
Dowanol eipat
Ethylene glycol isopropyl ether
Ethylene glycol, monoisopropyl ether
Isopropyl cellosolve
Isopropyl glycol
Isopropyl oxitol
Isopropylethylene glycol ether
Monoisopropyl ether of ethylene glycol
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,627,1986 |
| skin /rabbit | 20 mg/24H | moderate | 85JCAE -,627,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 1930 ppm/7H | Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria | JIHTAB 25,157,1943 |
| inhalation/rat | lethal concentration (50 percent kill): 3100 mg/m3/4H | 85GMAT -,67,1982 | |
| intraperitoneal/mammal (species unspecified) | lowest published toxic dose: 100 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,165,1984 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1860 mg/kg | 85GMAT -,67,1982 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia | VCVGK* -,165,1984 |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 800 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia | VCVGK* -,165,1984 |
| intraperitoneal/rat | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression Blood: Other hemolysis with or without anemia | VCVGK* -,165,1984 |
| intraperitoneal/rat | lethal dose (50 percent kill): 800 mg/kg | 85GMAT -,67,1982 | |
| oral/mouse | lethal dose (50 percent kill): 4900 mg/kg | 85GMAT -,67,1982 | |
| oral/rat | lethal dose (50 percent kill): 5660 µL/kg | AIHAAP 30,470,1969 | |
| skin/rabbit | lethal dose (50 percent kill): 1600 µL/kg | AIHAAP 30,470,1969 | |
| unreported route/mouse | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes | GISAAA 41(11),7,1976 |
| unreported route/rat | lethal dose (50 percent kill): 1250 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Other changes | GISAAA 41(11),7,1976 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 200 ppm/6H/26W- intermittent | Cardiac: Changes in heart weight Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0556079 |
| inhalation/guinea pig | lowest published toxic concentration: 200 ppm/6H/26W- intermittent | Liver: Liver function tests impaired Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0556079 |
| inhalation/rabbit | lowest published toxic concentration: 200 ppm/6H/26W- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Musculoskeletal: Other changes | NTIS** OTS0556079 |
| inhalation/rat | lowest published toxic concentration: 1000 mg/m3/4H/30D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in cell count (unspecified) | VCVGK* -,165,1994 |
| inhalation/rat | lowest published toxic concentration: 30 mg/m3/90D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,165,1994 |
| inhalation/rat | lowest published toxic concentration: 1650 mg/m3/7H/5W- intermittent | Blood: Changes in spleen | JIHTAB 25,374,1943 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/24H/13W- continuous | Endocrine: Hypoglycemia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 41(11),7,1976 |
| inhalation/rat | lowest published toxic concentration: 142 ppm/6H/4W- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Changes in spleen Blood: Changes in erythrocyte (RBC) count | INHTE5 4,43,1992 |
| inhalation/rat | lowest published toxic concentration: 200 ppm/6H/26W- intermittent | Endocrine: Changes in spleen weight Blood: Other changes Blood: Changes in erythrocyte (RBC) count | NTIS** OTS0556079 |
| subcutaneous/rat | lowest published toxic dose: 1562.55 mg/kg/4W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 82,125,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 25 ppm (skin) | DTLVS* TLV/BEI,2013 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division