Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-methoxy-
RTECS #
KL5775000CAS #
109-86-4Updated
September 201Molecular Weight
76.11Molecular Formula
C3H8O2Synonyms
2-Methoxy-aethanol (German)2-Methoxyethanol
2-Methoxyethanol (ACGIH:OSHA)
2-Metossietanolo (Italian)
Aethylenglykol-monomethylaether (German)
Dowanol 7
Dowanol EM
EGME
Ether monomethylique de l'ethylene-glycol (French)
Ethylene glycol methyl ether
Ethylene glycol monomethyl ether
Glycol ether EM
Glycol monomethyl ether
Glycolmethyl ether
Jeffersol EM
Methoxyethanol
Methoxyhydroxyethane
Methyl cellosolve
Methyl cellosolve (OSHA)
Methyl cellosolve methyl glycol
Methyl ethoxol
Methyl glycol
Methyl oxitol
Methylcelosolv (Czech)
Methylglykol (German)
Metil cellosolve (Italian)
Metoksyetylowy alkohol (Polish)
Monomethyl ether of ethylene glycol
Poly-Solv EM
Prist
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /guinea pig | 10 µg | mild | JPPMAB 11,150,1959 |
| eye /rabbit | 97 mg | TXAPA9 19,276,1971 | |
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,623,1986 |
| skin /rabbit | 483 mg/24H | mild | TXAPA9 19,276,1971 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 150 mmol/L | MUREAV 320,125,1994 |
| DNA Damage | oral/rat | 800 mg/kg/4D- intermittent | TOXID9 44,114,2005 |
| Dominant Lethal Test | oral/rat | 500 mg/kg | ENMUDM 6,390,1984 |
| sperm morphology | oral/rat | 500 mg/kg | ENMUDM 6,390,1984 |
| sperm morphology | oral/mouse | 500 mg/kg | ENMUDM 6,390,1984 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 68 mg/kg/4H (1-19D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAVUAI 21,30,1989 |
| inhalation/rat | 30 ppm/6H (65D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 3,49,1983 |
| inhalation/rat | 100 ppm/6H (6-17D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TXAPA9 69,43,1983 |
| inhalation/rat | 100 ppm/6H (6-17D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 69,43,1983 |
| inhalation/rat | 30 ppm/6H (13W male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 3,80,1983 |
| inhalation/mouse | 1000 ppm/6H (11D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 61,368,1981 |
| inhalation/mouse | 500 ppm/7H (5D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TXAPA9 70,303,1983 |
| inhalation/mouse | 50 ppm/6H (6-15D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Urogenital system | TXAPA9 75,409,1984 |
| inhalation/mouse | 50 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | EVHPAZ 57,7,1984 |
| inhalation/rabbit | 300 ppm/6H (65D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 3,49,1983 |
| inhalation/rabbit | 50 ppm/6H (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Urogenital system | TXAPA9 75,409,1984 |
| inhalation/rabbit | 50 ppm/6H (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Musculoskeletal system | EVHPAZ 57,7,1984 |
| inhalation/rabbit | 10 ppm/6H (6-18D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 75,409,1984 |
| inhalation/rat | 933 mg/m3 (6-17D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | VCVGK* -,160,1994 |
| intraperitoneal/rat | 330 mg/kg (12D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TJADAB 29(2),54A,1984 |
| intraperitoneal/rat | 190 mg/kg (14D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Urogenital system | JJATDK 4,35,1984 |
| intraperitoneal/rat | 190 mg/kg (12D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | JJATDK 4,35,1984 |
| intraperitoneal/rat | 190 mg/kg (8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JJATDK 4,35,1984 |
| intravenous/mouse | 250 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 12,101,1992 |
| oral/monkey | 930 mg/kg (20-45D pregnant) | Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetal death | TJADAB 35,66A,1987 |
| oral/monkey | 633 mg/kg (20-45D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 35,66A,1987 |
| oral/hamster | 1562 mg/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EVHPAZ 57,75,1984 |
| oral/mouse | 11200 mg/kg (7-14D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | EVHPAZ 57,141,1984 |
| oral/guinea pig | 6250 mg/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EVHPAZ 57,75,1984 |
| oral/rat | 250 mg/kg (13D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 145,415,1997 |
| oral/mouse | 175 mg/kg (11D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TJADAB 31,48A,1985 |
| oral/mouse | 2 gm/kg (7-14D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system | TXCYAC 20,335,1981 |
| oral/mouse | 500 mg/kg (9D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 80,108,1985 |
| oral/mouse | 250 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 80,108,1985 |
| oral/mouse | 6250 mg/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | SAIGBL 21,29,1979 |
| oral/rat | 175 mg/kg (7-13D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TJADAB 32,33,1985 |
| oral/rat | 175 mg/kg (7-13D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Biochemical and metabolic | DCTODJ 9,1,1986 |
| oral/rat | 15015 mg/kg (13W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | NTPTR* NIH-93-3349 |
| oral/rat | 100 mg/kg (1D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 69,385,1983 |
| oral/rat | 350 mg/kg (9-15D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TXAPA9 86,197,1986 |
| oral/rat | 1000 mg/kg (6-17D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
| oral/mouse | 1000 mg/kg (6-17D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
| oral/rabbit | 1000 mg/kg (6-17D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,160,1994 |
| oral/rat | 350 mg/kg (9-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 82,197,1986 |
| oral/rat | 350 mg/kg (9-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TXAPA9 82,197,1986 |
| oral/mouse | 2 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89152565 |
| oral/mouse | 4.45 gm/kg (7D prior to copulation/21D pregnant) | Reproductive: Maternal effects: Postpartum | NTIS** #PB86163136 |
| oral/rat | 5.5 gm/kg (21W male) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321/AS |
| oral/mouse | 5.6 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86163136 |
| oral/mouse | 7.2 gm/kg (7D male/7D pre-1D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB88192240 |
| oral/mouse | 8.4 gm/kg (7D male/7D prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB88192240 |
| oral/mouse | 11.8 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86163136 |
| oral/mouse | 14 gm/kg (14D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | NTIS** #PB86163136 |
| oral/mouse | 14 gm/kg (14D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | NTIS** #PB86163136 |
| oral/mouse | 17.5 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB89152565 |
| oral/mouse | 35.28 gm/kg (15W prior to copulation) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86163136 |
| oral/rat | 36.75 gm/kg (21W male/21W prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB90252321/AS |
| oral/mouse | 43 gm/kg (15W male/15W pre-3W after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89152565 |
| oral/rat | 30 mg/kg (multigenerations) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
| oral/rat | 37.5 mg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321/AS |
| oral/mouse | 50 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB89152565 |
| oral/mouse | 159 mg/kg (multigenerations) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86163136 |
| oral/mouse | 159 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB86163136 |
| oral/mouse | 170 mg/kg (multigenerations) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB89152565 |
| oral/rat | 1050 mg/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
| oral/rat | 3570 mg/kg (17W male) | Reproductive: Effects on newborn: Sex ratio | NTIS** #PB90252321 |
| oral/mouse | 19 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility | NTIS** #PB88211446 |
| oral/rat | 15 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB90252321 |
| oral/mouse | 200 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB88211446 |
| oral/rat | 262 mg/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB90252321 |
| oral/mouse | 60 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB88211446 |
| oral/rat | 750 mg/kg (18D prior to copulation/0-6D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on fertility: Other measures of fertility | JTSCDR 34,SP121,2009 |
| oral/rat | 2400 mg/kg (17D prior to copulation/0-6D pregnant) | Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | JTSCDR 34,SP121,2009 |
| oral/rat | 7800 mg/kg (19D prior to copulation/0-6D pregnant) | Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | JTSCDR 34,SP121,2009 |
| oral/rat | 150 mg/kg (3D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOLED5 190,193,2009 |
| skin/rat | 11592 mg/kg (6-17D pregnant) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on embryo or fetus: Fetal death | JJATDK 6,165,1986 |
| skin/rat | 4375 mg/kg (7D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TXAPA9 100,145,1989 |
| skin/rat | 2 gm/kg (10D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAATDF 15,448,1990 |
| skin/rat | 1 gm/kg (12D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Gastrointestinal system | FAATDF 15,448,1990 |
| skin/guinea pig | 65 gm/kg (65D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 6,339,1986 |
| skin/rat | 2.5 mg/kg (7-16D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | VCVGK* -,159,1994 |
| subcutaneous/mouse | 1200 mg/kg (7-13D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOLED5 50,263,1990 |
| subcutaneous/mouse | 3200 mg/kg (7-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TOLED5 50,263,1990 |
| subcutaneous/mouse | 250 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 54,219,1996 |
| subcutaneous/rat | 600 mg/kg (6-20D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | EVHPAZ 57,199,1984 |
| subcutaneous/rat | 440 mg/kg (7-17D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TCMUD8 7,73,1987 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 414 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 200 mmol/L/48H | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 50 mmol/L/48H | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 50 mmol/L/48H | Reproductive: Other effects to embryo or fetus | TIVIEQ 7,777,1993 |
| inhalation/human | lowest published toxic concentration: 25 ppm | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | JIHTAB 20,134,1938 |
| inhalation/mouse | lethal concentration (50 percent kill): 1480 ppm/7H | Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria | JIHTAB 25,157,1943 |
| inhalation/mouse | lethal concentration (50 percent kill): 4600 ppm | ENTOX* -,63,2005 | |
| inhalation/rat | lowest published toxic concentration: 625 ppm/4H | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | ATSUDG 7,167,1984 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/4H | Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | ATSUDG 7,167,1984 |
| inhalation/rat | lethal concentration (50 percent kill): 1500 ppm/7H | NPIRI* 1,57,1974 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 2147 mg/kg | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Changes in spleen Blood: Other changes | FEPRA7 6,342,1947 |
| intraperitoneal/rat | lethal dose (50 percent kill): 2500 mg/kg | NPIRI* 1,57,1974 | |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Reproductive: Effects on fertility: Other measures of fertility | REPTED 14,45,2000 |
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1984 |
| intravenous/rat | lethal dose (50 percent kill): 2068 mg/kg | Blood: Other hemolysis with or without anemia | AMIHAB 14,114,1956 |
| oral/guinea pig | lethal dose (50 percent kill): 950 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/guinea pig | lowest published toxic dose: 200 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EXMPA6 61,119,1994 |
| oral/guinea pig | lowest published toxic dose: 300 mg/kg | Blood: Other changes | EXMPA6 61,119,1994 |
| oral/human | lowest published lethal dose: 3380 mg/kg | Gastrointestinal: Gastritis Liver: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 28,267,1946 |
| oral/human | lowest published lethal dose: 143 mg/kg | VCVGK* -,159,1984 | |
| oral/mouse | lethal dose (50 percent kill): 2800 mg/kg | Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
| oral/mouse | lethal dose (50 percent kill): 2560 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Cardiac: Other changes | GTPZAB 32(3),48,1988 |
| oral/rabbit | lethal dose (50 percent kill): 890 mg/kg | Behavioral: General anesthetic Blood: Other hemolysis with or without anemia | AMIHAB 14,114,1956 |
| oral/rabbit | lethal dose (50 percent kill): 890 mg/kg | Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
| oral/rat | lethal dose (50 percent kill): 2460 mg/kg | Behavioral: Somnolence (general depressed activity) Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,159,1984 |
| oral/rat | lowest published toxic dose: 250 mg/kg | Related to Chronic Data: Changes in prostate weight | REPTED 6,491,1992 |
| oral/rat | lethal dose (50 percent kill): 2370 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Lung, Thorax, or Respiration: Other changes | VHTODE 29,361,1987 |
| oral/rat | lowest published toxic dose: 2000 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JTSCDR 32,515,2007 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | JTSCDR 32,515,2007 |
| oral/rat | lowest published toxic dose: 200 mg/kg | Blood: Normocytic anemia Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
| oral/rat | lowest published toxic dose: 150 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | JOAND3 5,369,1984 |
| oral/rat | lowest published toxic dose: 200 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TOXID9 44,114,2005 |
| skin/rabbit | lethal dose (50 percent kill): 2000 mg/kg | Kidney, Ureter, and Bladder: Urine volume decreased or anuria | VCVGK* -,159,1984 |
| skin/rabbit | lethal dose (50 percent kill): 1280 mg/kg | NPIRI* 1,57,1974 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 750 ppm/7H/12W- intermittent | Blood: Microcytosis with or without anemia Blood: Other changes | JIHTAB 25,409,1943 |
| inhalation/Dog | lowest published toxic concentration: 2500 mg/m3/7H/60D- intermittent | Blood: Changes in spleen Blood: Microcytosis with or without anemia | VCVGK* -,160,1994 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 1240 mg/m3/6H/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Brain and Coverings: Other degenerative changes | VCVGK* -,159,1994 |
| inhalation/mouse | lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1994 |
| inhalation/mouse | lowest published toxic concentration: 1000 ppm/6H/11D- intermittent | Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | TXAPA9 61,368,1981 |
| inhalation/mouse | lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittent | Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,159,1994 |
| inhalation/rabbit | lowest published toxic concentration: 300 ppm/6H/13W- intermittent | Endocrine: Changes in thymus weight Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Changes in testicular weight | FAATDF 3,49,1983 |
| inhalation/rat | lowest published toxic concentration: 300 ppm/6H/13W- intermittent | Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 3,49,1983 |
| inhalation/rat | lowest published toxic concentration: 970 mg/m3/7H/5W- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in spleen | JIHTAB 25,374,1943 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/6H/11D- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in bone marrow not included in above Blood: Changes in leukocyte (WBC) count | TXAPA9 61,368,1981 |
| inhalation/rat | lowest published toxic concentration: 400 ppm/6H/2W- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | ENVRAL 22,423,1980 |
| inhalation/rat | lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,159,1994 |
| inhalation/rat | lowest published toxic concentration: 3680 mg/m3/6H/9D- intermittent | Spinal Cord: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,159,1994 |
| inhalation/rat | lowest published toxic concentration: 1100 mg/m3/10D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,160,1994 |
| intraperitoneal/rat | lowest published toxic dose: 450 mg/kg/16D- intermittent | Blood: Changes in other cell count (unspecified) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TIHEEC 9,617,1993 |
| oral/guinea pig | lowest published toxic dose: 600 mg/kg/3D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
| oral/mouse | lowest published toxic dose: 12110 mg/kg/2W- continuous | Endocrine: Changes in thymus weight Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-93-3349 |
| oral/mouse | lowest published toxic dose: 82 gm/kg/13W- continuous | Endocrine: Effect on menstrual cycle Endocrine: Other changes Blood: Changes in spleen | NTPTR* NIH-93-3349 |
| oral/mouse | lowest published toxic dose: 11200 mg/kg/8D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,141,1984 |
| oral/mouse | lowest published toxic dose: 8820 mg/kg/21W- continuous | Kidney, Ureter, and Bladder: Changes in kidney weight | NTIS** #PB88211446 |
| oral/mouse | lowest published toxic dose: 29400 mg/kg/21W- continuous | Liver: Changes in liver weight | NTIS** #PB88211446 |
| oral/mouse | lowest published toxic dose: 80850 mg/kg/21W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB88211446 |
| oral/mouse | lowest published toxic dose: 8820 mg/kg/21W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB88211446 |
| oral/mouse | lowest published toxic dose: 126000 mg/kg/15W- continuous | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB89152565 |
| oral/mouse | lowest published toxic dose: 17850 mg/kg/15W- continuous | Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB89152565 |
| oral/mouse | lowest published toxic dose: 6300 mg/kg/15W- continuous | Liver: Changes in liver weight | NTIS** #PB88192240 |
| oral/mouse | lowest published toxic dose: 4200 mg/kg/7D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB88192240 |
| oral/mouse | lowest published toxic dose: 4200 mg/kg/7D- continuous | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | NTIS** #PB88192240 |
| oral/mouse | lowest published toxic dose: 9800 mg/kg/49D- continuous | Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes | NTIS** #PB88192240 |
| oral/mouse | lowest published toxic dose: 21665 mg/kg/28D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB86163136 |
| oral/mouse | lowest published toxic dose: 35280 mg/kg/15W- continuous | Reproductive: Maternal effects: Menstrual cycle changes or disorders | NTIS** #PB86163136 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/1W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 25,259,2000 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/2W- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | JTSCDR 25,259,2000 |
| oral/rat | lowest published toxic dose: 200 mg/kg/2D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 40,169,1984 |
| oral/rat | lowest published toxic dose: 600 mg/kg/3D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 61,119,1994 |
| oral/rat | lowest published toxic dose: 900 mg/kg/3D- intermittent | Reproductive: Maternal effects: Menstrual cycle changes or disorders | TXAPA9 142,328,1997 |
| oral/rat | lowest published toxic dose: 4500 mg/kg/15D- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight | TXAPA9 142,328,1997 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/2W- continuous | Reproductive: Maternal effects: Oogenesis Reproductive: Effects on fertility: Other measures of fertility | REPTED 14,45,2000 |
| oral/rat | lowest published toxic dose: 29484 mg/kg/13W- continuous | Endocrine: Changes in thymus weight Blood: Changes in platelet count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* NIH-93-3349 |
| oral/rat | lowest published toxic dose: 10206 mg/kg/21D- continuous | Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 16,830,1991 |
| oral/rat | lowest published toxic dose: 500 mg/kg/10D- intermittent | Endocrine: Changes in thymus weight Immunological Including Allergic: Decreased immune response | TXAPA9 109,494,1991 |
| oral/rat | lowest published toxic dose: 500 mg/kg/10D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,160,1994 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/60D- intermittent | Endocrine: Changes in thymus weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | HPV004 -,-,2001 |
| oral/rat | lowest published toxic dose: 40500 mg/kg/60D- intermittent | Endocrine: Changes in thymus weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV004 -,-,2001 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/2W- intermittent | Endocrine: Changes in adrenal weight Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Menstrual cycle changes or disorders | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/4W- intermittent | Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in adrenal weight Reproductive: Maternal effects: Menstrual cycle changes or disorders | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 840 mg/kg/4W- intermittent | Endocrine: Changes in adrenal weight | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/2W- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 7800 mg/kg/26D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 3900 mg/kg/13D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 34,SP121,2009 |
| oral/rat | lowest published toxic dose: 700 mg/kg/7D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Changes in: Ca Related to Chronic Data: Changes in uterine weight | TXAPA9 82,197,1986 |
| oral/rat | lowest published toxic dose: 1200 mg/kg/8D- intermittent | Related to Chronic Data: Changes in testicular weight | JOAND3 5,369,1984 |
| skin/guinea pig | lowest published toxic dose: 65 gm/kg/13W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | FAATDF 6,339,1986 |
| skin/rat | lowest published toxic dose: 3200 mg/kg/4D- intermittent | Endocrine: Changes in thymus weight Immunological Including Allergic: Decrease in humoral immune response | TXCYAC 98,215,1995 |
| skin/rat | lowest published toxic dose: 20 gm/kg/4W- intermittent | Blood: Changes in other cell count (unspecified) Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | TXCYAC 57,209,1989 |
| subcutaneous/rat | lowest published toxic dose: 1902.75 mg/kg/4W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 82,125,2008 |
| subcutaneous/rat | lowest published toxic dose: 3805.5 mg/kg/4W- intermittent | Blood: Luekopenia Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 82,125,2008 |
| unreported route/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Other | TOXID9 90,219,2006 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FAATDF 13,747,1989 | |
| TOXICOLOGY REVIEW | CRTXB2 30,307,2000 | |
| TOXICOLOGY REVIEW | JTSCDR 25,1,2000 | |
| TOXICOLOGY REVIEW | CRTXB2 33,137,2003 | |
| TOXICOLOGY REVIEW | ENTOX* -,451,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,63,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,623,1996 | |
| TOXICOLOGY REVIEW | JTSCDR 34,SP1,2009 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | REPTED 33,269,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,241,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (80 mg/m3) (skin) | DTLVS* 3,158,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (16 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (15 mg/m3);KZW 20 ppm (60 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (16 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (16 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (1.6 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (16 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 ppm (3.2 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 15 mg/m3, short term exposure limit 60 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (16 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 ppm (0.31 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (16 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 25 ppm (80 mg/m3);short term exposure limit 35 ppm (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (16 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (16 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (16 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 60 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 5 ppm, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 ppm (3.2 mg/m3), KZG-week 8 ppm (25.6 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 25 ppm (80 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 25 ppm (80 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (16 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (80 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOMETHYL ETHER-air | 10H time-weighted average 0.1 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 46240; Number of Industries 89; Total Number of Facilities 8042; Number of Occupations 86; Total Number of Employees Exposed 168180; Total Number of Female Employees Exposed 53403 | |
| National Occupational Hazard Survey 1974 | Hazard Code 46240; Number of Industries 128; Total Number of Facilities 11165; Number of Occupations 102; Total Number of Employees Exposed 103424 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division