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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, chloromethyl methyl

RTECS #

KN6650000

CAS #

107-30-2

Updated

September 201

Molecular Weight

80.52

Molecular Formula

C2H5ClO

Synonyms

Chlordimethylether (Czech)
Chloromethyl methyl ether
Chloromethyl methyl ether (ACGIH:OSHA)
Chloromethyl methyl ether, technical grade
CMME
Dimethylchloroether
Ether methylique monochlore (French)
Ether, dimethyl chloro
Methoxychloromethane
Methylchloromethyl ether
Monochlorodimethyl ether
RCRA waste number U046

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlymphocyte/human5 mL/LCALEDQ 13,213,1981
morphological transformembryo/hamster10 mg/LAETODY 1,241,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/90DTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		AEHLAU 30,70,1975
inhalation/hamster lowest published toxic concentration: 1 ppm/852D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV174 -,-,2003
inhalation/mouse lowest published toxic concentration: 2 ppm/21W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV174 -,-,2003
inhalation/mouse lowest published toxic concentration: 2 ppm/82D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		AEHLAU 22,663,1971
inhalation/rat lowest published toxic concentration: 1 ppm/6H/72WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors		AEHLAU 30,70,1975
inhalation/rat lowest published toxic concentration: 1 ppm/852D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV174 -,-,2003
subcutaneous/mouse lowest published toxic dose: 5 ml/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains		HPV174 -,-,2003
subcutaneous/mouse lowest published toxic dose: 312 mg/kg/26W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		JNCIAM 46,143,1971
subcutaneous/mouse toxic dose: 852 mg/kg/71W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application		JNCIAM 48,1431,1972
subcutaneous/mouse toxic dose: 125 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		TXAPA9 15,92,1969

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lethal concentration (50 percent kill): 65 ppm/7HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage		AEHLAU 30,61,1975
inhalation/hamster lethal concentration (50 percent kill): 212.5 mg/m3/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		VCVGK* -,278,1994
inhalation/mouse Lowest published lethal concentration: 330 mg/m3/2HVCVGK* -,278,1994
inhalation/mouse lethal concentration (50 percent kill): 1030 mg/m3/2H85GMAT -,89,1982
inhalation/rabbit lowest published toxic concentration: 9 mg/m3Lung, Thorax, or Respiration: CoughVCVGK* -,278,1994
inhalation/rabbit lowest published toxic concentration: 27 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,278,1994
inhalation/rat lethal concentration (50 percent kill): 55 ppm/7HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage		AEHLAU 30,61,1975
inhalation/rat lethal concentration (50 percent kill): 179.8 mg/m3/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes		VCVGK* -,278,1994
inhalation/rat lethal concentration (50 percent kill): 55 ppm/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight		HPV174 -,-,2003
oral/rat lowest published lethal dose: 1000 mg/kgHPV174 -,-,2003
oral/rat lethal dose (50 percent kill): 223 mg/kgHPV174 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 6 mg/m3/130D- intermittentLung, Thorax, or Respiration: TumorsVCVGK* -,278,1994
inhalation/rabbit lowest published toxic concentration: 3 mg/m3/5H/90D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 32.7 mg/m3/30D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 3.27 mg/m3/130W- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Skin and Appendages: Tumors		VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 10 ppm/3D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV174 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,131,1987
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 733,39,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1108CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1006,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROMETHYL METHYL ETHER-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1006NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #10

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