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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene glycol, dinitrate

RTECS #

KW5600000

CAS #

628-96-6

Updated

September 201

Molecular Weight

152.08

Molecular Formula

C2H4N2O6

Synonyms

Dinitroglicol (Italian)
Dinitroglycol
EGDN
Ethanediol dinitrate
Ethylene dinitrate
Ethylene glycol dinitrate (ACGIH:OSHA)
Ethylene nitrate
Ethylenglykoldinitrat (Czech)
Glycol (dinitrate de) (French)
Glycol dinitrate
Glycoldinitraat (Dutch)
Glykoldinitrat (German)
Nitroglycol
Nitroglykol (Czech)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 540 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes		STGNBT -,96,1999
oral/rat lethal dose (50 percent kill): 460 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes		STGNBT -,96,1999
skin/rat lethal dose (50 percent kill): 3800 mg/kgSTGNBT -,96,1999
subcutaneous/cat lowest published lethal dose: 75 mg/kgBlood: Normocytic anemiaAEPPAE 200,271,1942
subcutaneous/rabbit lowest published lethal dose: 300 mg/kgVascular: Other changes

Blood: Normocytic anemia		AEPPAE 200,271,1942

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 mg/m3/17W- intermittentCardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells		STGNBT -,96,1999
oral/rat lowest published toxic dose: 3067 mg/kg/20D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		STGNBT -,96,1999
subcutaneous/rat lowest published toxic dose: 1 gm/kg/10D- intermittentBehavioral: Tolerance

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS		PHTOEH 61,172,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWNTIS** AD778-725
TOXICOLOGY REVIEWAJMEAZ 38,409,1965

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.31 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 ppm (0.3 mg/m3);KZW 0.2 ppm (1.2 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.31 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.02 ppm (0.12 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.03 ppm (0.2 mg/m3), short term exposure limit 0.1 ppm (0.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.17 ppm (1 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 ppm (0.32 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.02 ppm (0.12 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.05 ppm (0.31 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 ppm (0.3 mg/m3), skin, 2006
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (1.2 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 ppm (0.3 mg/m3);short term exposure limit 0.1 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.31 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.03 ppm (0.18 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 ppm (0,3 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 0.3 mg/m3, short term exposure limit 0.4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.03 ppm (0.2 mg/m3);short term exposure limit 0.1 ppm (0.6 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.05 ppm (0.3 mg/m3), skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.3 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 ppm (1.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 ppm (1 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 0.2 ppm (1 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 0.2 ppm (1 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 0.2 ppm (1 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 0.2 ppm (1 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL DINITRATE-airshort term exposure limit 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylene glycol dinitrate, 2507
OSHA ANALYTICAL METHOD #43

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