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Registry of Toxic Effects of Chemical Substances (RTECS)

Ferrocene

RTECS #

LK0700000

CAS #

102-54-5

Updated

September 201

Molecular Weight

186.05

Molecular Formula

C10H10Fe

Synonyms

Biscyclopentadienyliron
Catane
Di-2,4-cyclopentadien-1-yliron
Dicyclopentadienyl iron
Dicyclopentadienyl iron (ACGIH:OSHA)
Ferrotsen
Iron bis(cyclopentadiene)
Iron dicyclopentadienyl

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat202.5 gm/kg/1Y- intermittentTXCYAC 254,11,2008
heritable translocation testparenteral/Drosophila melanogaster100 ppmENMUDM 7,87,1985
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster100 ppmENMUDM 7,87,1985
sister chromatid exchangeovary/hamster130 µg/LENMUDM 7,1,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 5175 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application		NCIUS* PH43-64-886

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) Lethal concentration: >21700 µg/m3STGNBT -,228,1999
intraperitoneal/mouse lethal dose (50 percent kill): 335 mg/kgNCIUS* PH43-64-886
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgNCIUS* PH43-64-886
intravenous/mouse lethal dose (50 percent kill): 178 mg/kgCSLNX* NX#02382
oral/mouse lethal dose (50 percent kill): 832 mg/kgBJPCAL 24,352,1965
oral/rat lethal dose (50 percent kill): 1320 mg/kgSCCUR* -,5,1961

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 15800 µg/m3/17W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Fe		STGNBT -,228,1999
inhalation/mouse lowest published toxic concentration: 20 mg/m3/2W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 17,150,1991
inhalation/rat lowest published toxic concentration: 36 mg/m3/2W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FAATDF 17,150,1991
oral/Dog lowest published toxic dose: 54600 mg/kg/26W- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Endocrine: Other changes

Nutritional and Gross Metabolic: Changes in: Fe		TXAPA9 15,666,1969

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg(Fe)/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Fe)/m3, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON, total dust-airtime-weighted average 10 mg/m3NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENYL IRON-air10H time-weighted average 5 mg/m3NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code T2061; Number of Industries 2; Total Number of Facilities 14; Number of Occupations 3; Total Number of Employees Exposed 412; Total Number of Female Employees Exposed 328

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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