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Registry of Toxic Effects of Chemical Substances (RTECS)

Furfuryl alcohol

RTECS #

LU9100000

CAS #

98-00-0

Updated

September 201

Molecular Weight

98.11

Molecular Formula

C5H6O2

Synonyms

2-Furancarbinol
2-Furanmethanol
2-Furfurylalkohol (Czech)
2-Furylcarbinol
2-Furylmethanol
2-Hydroxymethylfuran
alpha-Furylcarbinol
Furfural alcohol
Furfuralcohol
Furfuryl alcohol (ACGIH:OSHA)
Furyl alcohol
Methanol, (2-furyl)-
NCI-C56224

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,787,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster2500 µmol/LCALEDQ 13,89,1981
DNA repair/Bacillus subtilis2 mg/discDFSCDX 13,353,1986
mutation in microorganisms/Salmonella typhimurium100 nmol/L/2DMUTAEX 27,41,2012

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 32 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTPTR* NTP-TR-482,1999
inhalation/mouse lowest published toxic concentration: 2016 mg/kg/105W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors		NTIS** PB99-151482
inhalation/rat lowest published toxic concentration: 32 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors		NTPTR* NTP-TR-482,1999
inhalation/rat lowest published toxic concentration: 1008 mg/kg/105W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors		NTIS** PB99-151482

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 597 ppm/6H34ZIAG -,280,1969
inhalation/rat lethal concentration (50 percent kill): 233 ppm/4HAIHAAP 19,91,1958
intraperitoneal/rat lethal dose (50 percent kill): 650 mg/kgNPIRI* 1,64,1974
intravenous/rabbit lethal dose (50 percent kill): 650 mg/kgFEPRA7 8,294,1949
oral/mammal (species unspecified) lethal dose (50 percent kill): 360 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 160 mg/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940
oral/rat lethal dose (50 percent kill): 177 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis		GTPZAB 25(9),52,1981
skin/rabbit lethal dose (50 percent kill): 400 mg/kgBehavioral: Convulsions or effect on seizure threshold34ZIAG -,280,1969
skin/rat lethal dose (50 percent kill): 3825 mg/kgGTPZAB 25(9),52,1981
subcutaneous/rat lethal dose (50 percent kill): 85 mg/kgBehavioral: Convulsions or effect on seizure threshold34ZIAG -,280,1969
unreported route/mouse lethal dose (50 percent kill): 338 mg/kgGISAAA 55(6),73,1990
unreported route/rabbit lethal dose (50 percent kill): 632 mg/kgGISAAA 55(6),73,1990
unreported route/rat lethal dose (50 percent kill): 460 mg/kgGISAAA 55(6),73,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 22 mg/m3/17W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		GTPZAB 25(9),52,1981
inhalation/mouse lowest published toxic concentration: 16 ppm/6H/16D- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-482,1999
inhalation/mouse lowest published toxic concentration: 2 ppm/6H/14W- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-482,1999
inhalation/rat lowest published toxic concentration: 250 mg/m3/2W- intermittentOlfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TOPADD 19,617,1991
inhalation/rat lowest published toxic concentration: 50 ppm/6H/16W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		ENVRAL 31,420,1983
inhalation/rat lowest published toxic concentration: 16 ppm/6H/16D- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-482,1999
inhalation/rat lowest published toxic concentration: 2 ppm/6H/14W- intermittentOlfaction: Other olfaction effectsNTPTR* NTP-TR-482,1999
oral/mouse lowest published toxic dose: 400 mg/kg/5D- intermittentLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression		FCTOD7 46,286,2008
oral/mouse lowest published toxic dose: 400 mg/kg/10D- intermittentLiver: Other changesFCTOD7 46,286,2008
oral/mouse lowest published toxic dose: 800 mg/kg/10D- intermittentKidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidneyFCTOD7 46,286,2008
oral/mouse lowest published toxic dose: 2400 mg/kg/60D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		FCTOD7 46,286,2008
oral/mouse lowest published toxic dose: 800 mg/kg/20D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesFCTOD7 46,286,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm;short term exposure limit 15 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWTXAPA9 243,180,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (20 mg/m3) (skin)DTLWS* 3,19,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm (60 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (20 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (41 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 15 ppm (61 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (8.1 mg/m3), short term exposure limit 10 ppm (41 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (40 mg/m3), Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 40 mg/m3, short term exposure limit 40 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 5 ppm (20 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm (45 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (40 mg/m3);short term exposure limit 15 ppm (60 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (40 mg/m3); short term exposure limit 15 ppm (60 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (40 mg/m3); short term exposure limit 15 ppm (60 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 ppm (40 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FURFURYL ALCOHOL-airtime-weighted average 10 ppm (Sk);short term exposure limit 15 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 34370; Number of Industries 46; Total Number of Facilities 2827; Number of Occupations 63; Total Number of Employees Exposed 77710; Total Number of Female Employees Exposed 14624
National Occupational Hazard Survey 1974Hazard Code 34370; Number of Industries 29; Total Number of Facilities 2939; Number of Occupations 38; Total Number of Employees Exposed 11577

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Furfuryl alcohol, 2505
NTP Carcinogenesis Studies (inhalation):some evidence:mouse, rat NTPTR* NTP-TR-482,1999

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