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Registry of Toxic Effects of Chemical Substances (RTECS)

Gasoline, natural

RTECS #

LX3300000

CAS #

8006-61-9

Updated

July 2013

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Automobile regular unleaded gasoline
Gasoline
Gasoline (ACGIH:OSHA)
Natural gasoline
Petrol
Petrol, natural

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 140 ppm/8H mildJIHTAB 25,225,1943
eye /man 500 ppm/1H moderateAEHLAU 1,548,1960

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 300 gm/m3/5MLung, Thorax, or Respiration: DyspneaNTIS** PB158-508
inhalation/mammal (species unspecified) Lowest published lethal concentration: 30000 ppm/5MAEPPAE 138,65,1928
inhalation/man lowest published toxic concentration: 900 ppm/1HEye: Conjunctiva irritation

Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Cough		JIHTAB 25,225,1943
inhalation/mouse lethal concentration (50 percent kill): 300 gm/m3/5MNTIS** PB158-508
inhalation/rat lethal concentration (50 percent kill): 300 gm/m3/5MNTIS** PB158-508
parenteral/man lowest published toxic dose: 53 mg/kgSkin: After systemic exposure: Dermatitis, allergicJTCTDW 21,409,1983/1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 3200 ppm/6H/4W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		TIHEEC 11,343,1995
inhalation/rat lowest published toxic concentration: 3 gm/m3/4H/43W- intermittentEye: Conjunctiva irritationVEOFA6 78(1),36,1965
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight		JAPTO* 25,193,2005
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		JAPTO* 25,193,2005
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesJAPTO* 25,193,2005
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Other changes in urine composition		JAPTO* 25,193,2005
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentEndocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes		JAPTO* 25,193,2005
inhalation/rat lowest published toxic concentration: 500 ppm/4W- intermittentBlood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites		JAPTO* 25,193,2005
oral/rat lowest published toxic dose: 1500 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionJAPTO* 21,461,2001
oral/rat lowest published toxic dose: 5 mg/kg/2W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight		TOLED5 44,13,1988
unreported route/man lowest published toxic dose: 16.5 mL/kg/7Y- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor		DADEDV 73,183,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 45,159,1989
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 45,159,1989
TOXICOLOGY REVIEWNEJMAG 342,186,2000
TOXICOLOGY REVIEWTOLED5 128,85,2002
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWMUREAV 613,138,2006
TOXICOLOGY REVIEWENTOX* -,408,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWAIRMJ* 20,8,2001
TOXICOLOGY REVIEWNEUCL* 15,711,1997
TOXICOLOGY REVIEWNEUCL* 18,215,2000
TOXICOLOGY REVIEWNBREV* 26,81,2002
TOXICOLOGY REVIEWNRTXDN 31,603,2010
TOXICOLOGY REVIEWMUREAV 728,88,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 300 ppm (903 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 500 ppm (1501 mg/m3), MAR2002
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (300 mg/m3), 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 300 ppm (900 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 300 ppm (890 mg/m3), short term exposure limit 500 ppm (1480 mg/m3), JAN2002
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (2000 mg/m3), JAN2011
Occupational Exposure Limit-TURKEYtime-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Appendix A3CFRGBR 29,1926.55,1994

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GASOLINE-airCarcinogen (15 ppm LOQ)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6705; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 70; Total Number of Female Employees Exposed 7

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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