Registry of Toxic Effects of Chemical Substances (RTECS)
4-Heptanone
RTECS #
MJ5600000CAS #
123-19-3Updated
September 201Molecular Weight
114.21Molecular Formula
C7H14OSynonyms
ButyroneDipropyl ketone
Dipropyl ketone (ACGIH)
GBL
Heptan-4-one
Propyl ketone
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /rabbit | 500 mg/24H | mild | 85JCAE -,286,1986 |
skin /rabbit | 500 mg/24H | mild | 85JCAE -,286,1986 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lethal concentration (50 percent kill): 2690 ppm/6H | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | 38MKAJ 2C,4764,1982 |
intravenous/mouse | lowest published lethal dose: 271 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) | APTOA6 37,56,1975 |
oral/rat | lethal dose (50 percent kill): 3730 µL/kg | TXAPA9 28,313,1974 | |
skin/rabbit | lethal dose (50 percent kill): 5660 µL/kg | TXAPA9 28,313,1974 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 250 gm/m3/5D- intermittent | Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) | TXAPA9 197,280,2004 |
oral/rat | lowest published toxic dose: 30 gm/kg/3W- intermittent | Behavioral: Somnolence (general depressed activity) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0571116 |
oral/rat | lowest published toxic dose: 130 gm/kg/13W- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0571116 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 50 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPROPYL KETONE-air | 10H time-weighted average 50 ppm | NIOSH* DHHS #95-121,1995 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division