Registry of Toxic Effects of Chemical Substances (RTECS)
Hydantoin, 1,3-dichloro-5,5-dimethyl-
RTECS #
MU0700000CAS #
118-52-5; 55945-60-3Updated
September 201Molecular Weight
197.03Molecular Formula
C5H6Cl2N2O2Synonyms
1,3-Dichloro-5,5-dimethyl hydantoin1,3-Dichloro-5,5-dimethyl hydantoin (ACGIH:OSHA)
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
1,3-Dichloro-5,5-dimethylhydantoin
1,3-Dichloro-5,5'-methylhydantoin
1,3-Dwuchloro-5,5-dwumetylohydantoina (Polish)
2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl- (9CI)
Dactin
Daktin
Dantoin
Dichlorantin
Dwuchlorantyny (Polish)
Halane
Hydan
Hydan (antiseptic)
Hydantoin, dichlorodimethyl-
NCI-C03054
Omchlor
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg/24H | severe | EPASR* 8EHQ-0281-0382 |
skin /rabbit | 100 mg/24H | severe | EPASR* 8EHQ-0281-0382 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
morphological transform | embryo/rat | 6300 ng/plate | JJATDK 1,190,1981 |
sex chromosome loss and nondisjunction | parenteral/Drosophila melanogaster | 250 ppm | ENMUDM 7,677,1985 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | Lowest published lethal concentration: 20 gm/m3/1H | Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Changes in structure or function of salivary glands | EPASR* 8EHQ-0281-0382 |
oral/guinea pig | lethal dose (50 percent kill): 1350 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Lung, Thorax, or Respiration: Dyspnea | GISAAA 47(6),76,1982 |
oral/rabbit | lethal dose (50 percent kill): 1520 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Lung, Thorax, or Respiration: Dyspnea | GISAAA 47(6),76,1982 |
oral/rat | lethal dose (50 percent kill): 542 mg/kg | 85INA8 5,183,1986 | |
skin/rabbit | lethal dose (50 percent kill): >20 gm/kg | EPASR* 8EHQ-0281-0382 | |
unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 500 mg/kg | GWXXBX #2550828 | |
unreported route/rat | lethal dose (50 percent kill): 550 mg/kg | BCTKAG 19,52,1986 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 8784 mg/kg/28D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BCTKAG 19,52,1986 |
oral/rat | lowest published toxic dose: 634 mg/kg/30D- intermittent | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 47(6),76,1982 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3 | DTLVS* TLV/BEI,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.2 mg/m3 | DTLVS* 3,78,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, inhal, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg/m3, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.2 mg/m3, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.2 mg/m3, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JUL2005 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 mg/m3, inhal, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.2 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.2 mg/m3, JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.2 mg/m3 | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.2 mg/m3 | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.2 mg/m3 | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.2 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air | 10H time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 24100; Number of Industries 9; Total Number of Facilities 436; Number of Occupations 10; Total Number of Employees Exposed 3502; Total Number of Female Employees Exposed 1780 | |
National Occupational Hazard Survey 1974 | Hazard Code 24100; Number of Industries 5; Total Number of Facilities 729; Number of Occupations 6; Total Number of Employees Exposed 2224 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division