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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydantoin, 1,3-dichloro-5,5-dimethyl-

RTECS #

MU0700000

CAS #

118-52-5; 55945-60-3

Updated

September 201

Molecular Weight

197.03

Molecular Formula

C5H6Cl2N2O2

Synonyms

1,3-Dichloro-5,5-dimethyl hydantoin
1,3-Dichloro-5,5-dimethyl hydantoin (ACGIH:OSHA)
1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
1,3-Dichloro-5,5-dimethylhydantoin
1,3-Dichloro-5,5'-methylhydantoin
1,3-Dwuchloro-5,5-dwumetylohydantoina (Polish)
2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl- (9CI)
Dactin
Daktin
Dantoin
Dichlorantin
Dwuchlorantyny (Polish)
Halane
Hydan
Hydan (antiseptic)
Hydantoin, dichlorodimethyl-
NCI-C03054
Omchlor

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H severeEPASR* 8EHQ-0281-0382
skin /rabbit 100 mg/24H severeEPASR* 8EHQ-0281-0382

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat6300 ng/plateJJATDK 1,190,1981
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster250 ppmENMUDM 7,677,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 20 gm/m3/1HBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
EPASR* 8EHQ-0281-0382
oral/guinea pig lethal dose (50 percent kill): 1350 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea
GISAAA 47(6),76,1982
oral/rabbit lethal dose (50 percent kill): 1520 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Dyspnea
GISAAA 47(6),76,1982
oral/rat lethal dose (50 percent kill): 542 mg/kg85INA8 5,183,1986
skin/rabbit lethal dose (50 percent kill): >20 gm/kgEPASR* 8EHQ-0281-0382
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgGWXXBX #2550828
unreported route/rat lethal dose (50 percent kill): 550 mg/kgBCTKAG 19,52,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8784 mg/kg/28D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBCTKAG 19,52,1986
oral/rat lowest published toxic dose: 634 mg/kg/30D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 47(6),76,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.2 mg/m3DTLVS* 3,78,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.2 mg/m3; short term exposure limit 0.4 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 0.2 mg/m3;short term exposure limit 0.4 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24100; Number of Industries 9; Total Number of Facilities 436; Number of Occupations 10; Total Number of Employees Exposed 3502; Total Number of Female Employees Exposed 1780
National Occupational Hazard Survey 1974Hazard Code 24100; Number of Industries 5; Total Number of Facilities 729; Number of Occupations 6; Total Number of Employees Exposed 2224

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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