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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrazine, phenyl-

RTECS #

MV8925000

CAS #

100-63-0

Updated

September 201

Molecular Weight

108.16

Molecular Formula

C6H8N2

Synonyms

Fenilidrazina (Italian)
Fenylhydrazine (Dutch)
Hydrazine-benzene
Hydrazinobenzene
Phenylhydrazin (German)
Phenylhydrazine
Phenylhydrazine (ACGIH:OSHA)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/mouse350 µmol/kgCNREA8 41,1469,1981
DNA repair/Escherichia coli500 ng/wellMUREAV 133,161,1984
gene conversion and mitotic recombination/Saccharomyes cerevisiae25 mg/LMUREAV 308,159,1994
mutation in microorganisms/Other microorganisms150 µg/L (-enzymatic activation step)MUREAV 173,233,1986
mutation in microorganisms/Salmonella typhimurium4600 nmol/plate (+/-enzymatic activation step)CNREA8 41,1469,1981
mutation in microorganisms/Escherichia coli39100 ng/plate (-enzymatic activation step)MUREAV 412,17,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 30 mg/kg (17-19D pregnant)Reproductive: Effects on newborn: BehavioralTJADAB 8,97,1973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 5200 mg/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors		GTPZAB 19(6),28,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 2120 mg/m3TLSMA6 115,59,1977
inhalation/rat lethal concentration (50 percent kill): 2610 mg/m3TLSMA6 115,59,1977
intraperitoneal/mouse lethal dose (50 percent kill): 170 mg/kgCNREA8 41,1469,1981
intraperitoneal/rat lowest published toxic dose: 125 mg/kgVascular: BP lowering not characterized in autonomic section

Blood: Changes in cell count (unspecified)

Blood: Other hemolysis with or without anemia		BPBLEO 30,661,2007
intravenous/Dog lowest published lethal dose: 120 mg/kgXPHBAO 271,159,1941
oral/Dog lowest published lethal dose: 200 mg/kgXPHBAO 271,159,1941
oral/guinea pig lethal dose (50 percent kill): 80 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity		HYSAAV 30(7-9),191,1965
oral/mouse lethal dose (50 percent kill): 175 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)		GISAAA 30(8),21,1965
oral/rabbit lethal dose (50 percent kill): 80 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity		HYSAAV 30(7-9),191,1965
oral/rat lethal dose (50 percent kill): 188 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity		HYSAAV 30(7-9),191,1965
oral/rat lowest published toxic dose: 125 mg/kgVascular: BP elevation not characterized in autonomic sectionTOXID9 90,61,2006
oral/rat lowest published toxic dose: 125 mg/kgBlood: Other changesTXAPA9 225,102,2007
skin/rabbit lowest published lethal dose: 90 mg/kgLung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Hematuria		NTIS** OTS0546542
subcutaneous/guinea pig lowest published toxic dose: 50 mg/kgBrain and Coverings: Changes in circulation

Vascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi		TPKVAL 6,145,1964
subcutaneous/mouse lowest published lethal dose: 170 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes		JIHTAB 18,1,1936
unreported route/frog lowest published lethal dose: 300 mg/kgXPHBAO 271,159,1941

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/3D- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count		JJATDK 20,25,2000
intraperitoneal/rat lowest published toxic dose: 100 mg/kg/2D- intermittentBlood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count		JAPTO* 20,25,2000
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/3D- intermittentBlood: Changes in bone marrow not included in aboveJAPTO* 20,25,2000
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JTPAE7 21,249,2008
subcutaneous/guinea pig lowest published toxic dose: 100 mg/kg/4D- intermittentBlood: Normocytic anemiaTPKVAL 6,145,1964
subcutaneous/guinea pig lowest published toxic dose: 150 mg/kg/7D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 6,145,1964
subcutaneous/guinea pig lowest published toxic dose: 2730 mg/kg/0.5Y- intermittentBlood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Other		TPKVAL 6,145,1964
subcutaneous/rat lowest published toxic dose: 70 mg/kg/7D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count		JTSCDR 20,1,1995

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 627,78,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (22 mg/m3) (skin)DTLVS* 3,207,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.44 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (22 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (22 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (45 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (45 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.44 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.6 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.1 ppm (0.44 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 20 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (22 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (22 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (22 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (22 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (22 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (22 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (22 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-airCarcinogen ceiling concentration 0.03 ppm/120MNIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYLHYDRAZINE-airCarcinogen ceiling concentration 0.14 ppm/120M (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 57300; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 7; Total Number of Employees Exposed 212; Total Number of Female Employees Exposed 19
National Occupational Hazard Survey 1974Hazard Code 57300; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 5; Total Number of Employees Exposed 1120

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl hydrazine, 3518

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