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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrofluoric acid

RTECS #

MW7875000

CAS #

7664-39-3

Updated

September 201

Molecular Weight

20.01

Molecular Formula

FH

Synonyms

Acide fluorhydrique (French)
Acido fluoridrico (Italian)
Fluorowodor (Polish)
Fluorwasserstoff (German)
Fluorwaterstof (Dutch)
Hydrofluoride
Hydrogen fluoride
Hydrogen fluoride (ACGIH:OSHA)
RCRA waste number U134
Rubigine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 50 mg severeAMLTAS 37,110,1957
skin /rat 50%/3M severeJTCTDW 40,861,2002

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat1 mg/m3/6H/24D- intermittentCYGEDX 9(1),40,1975
DNA Damageinhalation/Drosophila melanogaster1300 ppb/6WATENBP 5,117,1971
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster2900 ppbFLUOA4 4,25,1971

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 470 µg/m3/4H (1-22D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)		GTPZAB 19(3),57,1975
inhalation/rat 4980 µg/m3/4H (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathGTPZAB 19(3),57,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 4327 ppm/15MEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AIHAAP 24,253,1963
inhalation/guinea pig Lowest published lethal concentration: 40 mg/m3/2HVCVN5* -,349,1993
inhalation/guinea pig lethal concentration (50 percent kill): 4327 ppmENTOX* -,542,2005
inhalation/guinea pig Lowest published lethal concentration: 25 mg/m3/5HVCVN5* -,349,1993
inhalation/human Lowest published lethal concentration: 200 mg/m3VCVN5* -,350,1993
inhalation/human lowest published toxic concentration: 25 mg/m3Lung, Thorax, or Respiration: Cough

Eye: Conjunctiva irritation		VCVN5* -,350,1993
inhalation/human Lowest published lethal concentration: 50 ppm/30M34ZIAG -,318,1969
inhalation/mammal (species unspecified) lowest published toxic concentration: 8 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,349,1993
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.03 mg/m3Eye: Other eye effectsVCVN5* -,349,1993
inhalation/man lowest published toxic concentration: 100 mg/m3/1MOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		JIDHAN 16,129,1934
inhalation/monkey lethal concentration (50 percent kill): 1774 ppm/1HBehavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Other changes		AMRL** TR-70-77,1970
inhalation/monkey lethal concentration (50 percent kill): 1774 ppmENTOX* -,542,2005
inhalation/mouse Lowest published lethal concentration: 263 ppm/1HTOXID9 78,149,2004
inhalation/mouse lethal concentration (50 percent kill): 342 ppmENTOX* -,542,2005
inhalation/mouse lethal concentration (50 percent kill): 342 ppm/1HEye: Corneal damage

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea		JCTODH 3,61,1976
inhalation/mouse lethal concentration (50 percent kill): 5000 mg/m3/5MVCVN5* -,349,1993
inhalation/mouse lethal concentration (50 percent kill): 270 mg/m3/60MVCVN5* -,349,1993
inhalation/rabbit Lowest published lethal concentration: 40 mg/m3/2HVCVN5* -,349,1993
inhalation/rabbit Lowest published lethal concentration: 260 mg/m3/7HAMIHBC 2,716,1950
inhalation/rabbit Lowest published lethal concentration: 25 mg/m3/5HVCVN5* -,349,1993
inhalation/rat lowest published toxic concentration: 148 mg/m3/6HOlfaction: Other olfaction effectsVCVN5* -,349,1993
inhalation/rat lethal concentration (50 percent kill): 1276 ppmENTOX* -,542,2005
inhalation/rat lethal concentration (50 percent kill): 1100 mg/m3/60MVCVN5* -,349,1993
inhalation/rat lethal concentration (50 percent kill): 1276 ppm/1HEye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands		AIHAAP 33,661,1972
intraperitoneal/rat lowest published lethal dose: 25 mg/kgTXAPA9 13,76,1968
intraperitoneal/rat lethal dose (50 percent kill): 25 mg/kgENTOX* -,542,2005
intravenous/rat lethal dose (50 percent kill): 17.4 mg/kgTIHEEC 23,5,2007
intravenous/rat lowest published lethal dose: 13.1 mg/kgTIHEEC 23,5,2007
intravenous/rat lowest published toxic dose: 3.2 mg/kgKidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: P		TIHEEC 23,5,2007
intravenous/rat lowest published toxic dose: 6.4 mg/kgEndocrine: Hyperglycemia

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis		TIHEEC 23,5,2007
intravenous/rat lowest published toxic dose: 9.6 mg/kgEndocrine: Hyperglycemia

Nutritional and Gross Metabolic: Changes in: K

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis		TIHEEC 23,5,2007
oral/man lowest published toxic dose: 143 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		JTCTDW 35,307,1997
skin/mouse lowest published lethal dose: 500 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression		SAIGBL 17,281,1975
subcutaneous/frog lowest published lethal dose: 112 mg/kgCRSBAW 124,133,1937

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 0.15 mg/m3/24H/78W- continuousMusculoskeletal: Changes in teeth and supporting structuresVCVN5* -,350,1989
inhalation/rat lowest published toxic concentration: 300 µg/m3/24H/22W- continuousBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 30(5),11,1965
inhalation/rat lowest published toxic concentration: 252 µg/m3/6H/17W- intermittentBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		GISAAA 41(5),6,1976
inhalation/rat lowest published toxic concentration: 72 mg/m3/3H/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,349,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/24H/4D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVN5* -,349,1989
inhalation/rat lowest published toxic concentration: 0.5 mg/m3/24H/17W- continuousMusculoskeletal: Changes in teeth and supporting structuresVCVN5* -,350,1989
inhalation/rat lowest published toxic concentration: 42.3 mg/m3/24H/6W- continuousMusculoskeletal: Changes in teeth and supporting structuresVCVN5* -,350,1989
subcutaneous/rat lowest published toxic dose: 364 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		FKIZA4 50,1397,1959

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-TVA 0.5 ppm;ceiling concentration 2 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJEMME* 10,163,1992
TOXICOLOGY REVIEWAMSSAQ 400,5,1963
TOXICOLOGY REVIEWDIMON* 46,551,2000
TOXICOLOGY REVIEWENTOX* -,542,2005
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWISMEA* 10,381,2008
TOXICOLOGY REVIEWCCACL* 21,719,2005
TOXICOLOGY REVIEWREPTED 29,1,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 3 ppm (2 mg/m3)DTLVS* 3,131,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 2 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAceiling concentration 3 ppm (2.6 mg(F)/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1.8 ppm (1.5 mg/m3);KZW 3 ppm (2.5 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1.8 ppm (1.5 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1.8 ppm (1.5 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 1.5 mg/m3 (1.8 ppm);short term exposure limit 2.5 mg/m3 (3 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 1.8 ppm (1.5 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1.8 ppm (1.5 mg/m3), VLE 3 ppm (2.5 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (0.83 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1.5 mg/m3, short term exposure limit 2.5 mg/m3, Skin, SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.7 ppm (0.6 mg/m3), short term exposure limit 3 ppm (2.5 mg/m3), NOV2011
Occupational Exposure Limit-JAPANceiling concentration 3 ppm (2.5 mg/m3), MAY2012
Occupational Exposure Limit-KOREAceiling concentration 3 ppm (2.5 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 3 ppm (2.5 mg(F)/m3), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 3 ppm (2.6 mg(F)/m3), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.8 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1,8 ppm (1,5 mg/m3); short term exposure limit 3 ppm (2,5 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg(F)/m3, short term exposure limit 0.5 mg(F)/m3, JUN2003
Occupational Exposure Limit-SWEDENceiling concentration 2 ppm (1.7 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (0.83 mg/m3), KZG-week 2 ppm (1.66 mg/m3), JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1.8 ppm (1.5 mg(F)/m3);short term exposure limit 3 ppm (2.5 mg(F)/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 3 ppm (2 mg(F)/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 3 ppm (2 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 3 ppmCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 3 ppm (2 mg(F)/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN FLUORIDE-air10H time-weighted average 3 ppm;short term exposure limit 6 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 38550; Number of Industries 96; Total Number of Facilities 11332; Number of Occupations 89; Total Number of Employees Exposed 189051; Total Number of Female Employees Exposed 68792
National Occupational Hazard Survey 1974Hazard Code 38550; Number of Industries 97; Total Number of Facilities 6590; Number of Occupations 68; Total Number of Employees Exposed 68886

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182566/AS)
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID110

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