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Registry of Toxic Effects of Chemical Substances (RTECS)

Iron, tris(dimethyldithiocarbamato)-

RTECS #

NO8750000

CAS #

14484-64-1; 301-05-3; 13494-27-4; 64070-92-4

Updated

September 201

Molecular Weight

416.51

Molecular Formula

C9H18N3S6·Fe

Synonyms

Aafertis
Bercema fertam 50
Carbamic acid, dimethyldithio-, iron salt
Carbamodithioic acid, dimethyl-, iron complex
Dimethylcarbamodithioic acid, iron complex
Dimethylcarbamodithioic acid, iron(3+) salt
Dimethyldithiocarbamic acid, iron salt
Dimethyldithiocarbamic acid, iron(3+) salt
Eisen(III)-tris(N,N-dimethyldithiocarbamat) (German)
Eisendimethyldithiocarbamat (German)
ENT 14,689
Ferbam
Ferbam (ACGIH:OSHA)
Ferbam 50
Ferberk
Fermate
Ferradow
Ferric dimethyldithiocarbamate
Fuklasin Ultra
Fuklazin
Hexaferb
Iron dimethyldithiocarbamate
Iron, tris(dimethylcarbamodithioato-S,S')-, (OC-6-11)-
Karbam Black
Liromate
Stauffer ferbam
Trimanzone
Tris(dimethyldithiocarbamato)iron
Tris(N,N-dimethyldithiocarbamato) iron(111)
Vancide FE95

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse30 mg/kgTCMUD8 22,451,2002
DNA repair/Bacillus subtilis2 µg/discMUREAV 40,19,1976
mutation in microorganisms/Other microorganisms1000 ppm (-enzymatic activation step)MMAPAP 50,233,1973
mutation in microorganisms/Salmonella typhimurium50 µg/plate (+enzymatic activation step)CSHCAL 4,267,1977
mutation in microorganisms/Salmonella typhimurium200 µg/plate (-enzymatic activation step)MBENDX 14,377,1986
sperm morphologyoral/mouse5 gm/kg/5D-continuousMUREAV 224,405,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1140 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		TXAPA9 35,83,1976
oral/rat 536 mg/kg (16-22D preg/21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXAPA9 35,83,1976
oral/rat 3479 mg/kg (16-22D preg/21D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)		TXAPA9 35,83,1976
oral/mouse 5 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 224,405,1989
subcutaneous/mouse 41760 µg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death		NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 3500 mg/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		NTIS** PB223-159
subcutaneous/mouse lowest published toxic dose: 100 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors		NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lowest published lethal dose: 2300 mg/kgJAPMA8 41,662,1952
intraperitoneal/mouse lethal dose (50 percent kill): 3 gm/kgJAPMA8 41,662,1952
intraperitoneal/rabbit lowest published lethal dose: 1500 mg/kgJAPMA8 41,662,1952
intraperitoneal/rat lethal dose (50 percent kill): 2700 mg/kgJAPMA8 41,662,1952
oral/guinea pig lowest published lethal dose: 2 gm/kgJAPMA8 41,662,1952
oral/mouse lethal dose (50 percent kill): 3400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia		JTEHD6 4,93,1978
oral/rabbit lowest published lethal dose: 3 gm/kgJAPMA8 41,662,1952
oral/rat lethal dose (50 percent kill): 1130 mg/kgFATOAO 32,356,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 9125 mg/kg/1Y- continuousBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JPETAB 118,174,1956
oral/rat lowest published toxic dose: 45 gm/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JAPMA8 41,662,1952
oral/rat lowest published toxic dose: 91250 mg/kg/2Y- continuousBrain and Coverings: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JPETAB 118,174,1956

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,121,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,121,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWFEREAC 72,32570,2007
TOXICOLOGY REVIEWFEREAC 72,53449,2007
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWHETOEA 26,321,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,173,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,113,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 15 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FERBAM-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0362; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205
National Occupational Hazard Survey 1974Hazard Code M0362; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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