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Registry of Toxic Effects of Chemical Substances (RTECS)

Isocyanic acid, 1,5-naphthylene ester

RTECS #

NQ9600000

CAS #

3173-72-6

Updated

July 2013

Molecular Weight

210.20

Molecular Formula

C12H6N2O2

Synonyms

1,5-Diisocyanatonaphthalene
1,5-Naphthalene diisocyanate
1,5-Naphthyl diisocyanate
Desmodur 15
Naphthalene, 1,5-diisocyanato- (9CI)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 270 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease		NTIS** OTS0572846
inhalation/rat Lowest published lethal concentration: 281 mg/m3/4HARTODN 78,243,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 19,303,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 71,1515,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,303,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1515,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1515,1999

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.01 ppm (0.09 mg/m3);KZW 0.02 ppm (0.18 mg/m3), sen, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.04 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 0.01 ppm (0.095 mg/m3), VLE 0.02 ppm (0.19 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.09 mg/m3, short term exposure limit 0.09 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.04 mg/m3), short term exposure limit 0.01 ppm (0.09 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 0.005 ppm (0.04 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,005 ppm (0,042 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 ppm (0.017 mg/m3), ceiling concentration 0.005 ppm (0.044 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.02 mg(NCO)/m3, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.04 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NDI-air10H time-weighted average 0.04 mg/m3;ceiling concentration 0.17 mg/m3/10MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521

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