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Registry of Toxic Effects of Chemical Substances (RTECS)

Isopropylamine

RTECS #

NT8400000

CAS #

75-31-0

Updated

September 201

Molecular Weight

59.13

Molecular Formula

C3H9N

Synonyms

1-Methylethylamine
2-Amino-propaan (Dutch)
2-Aminopropan (German)
2-Aminopropane
2-Amino-propano (Italian)
2-Propanamine
2-Propylamine
Isopropilamina (Italian)
Isopropylamine (ACGIH:OSHA)
Monoisopropylamine
Propane, 2-amino-
sec-Propylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL severeNTIS** OTS0542011
skin /rabbit 345 mg open irritation test moderateUCDS** 11/15/1971
skin /rabbit 10 mg/24H open irritation test severeAMIHBC 4,119,1951

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 1800 mg/m3TPKVAL 14,80,1975
inhalation/mouse Lowest published lethal concentration: 7000 ppm/40MSCCUR* -,7,1961
inhalation/rat lethal concentration (50 percent kill): 4000 ppm/4HIAEC** 17JUN1974
intraperitoneal/rat lowest published lethal dose: 50 mg/kgFATOAO 31,238,1968
intravenous/pig lowest published toxic dose: 75.24 mg/kgVascular: BP elevation not characterized in autonomic sectionJTCTDW 47,651,2009
oral/guinea pig lethal dose (50 percent kill): 2700 mg/kgGISAAA 45(3),79,1980
oral/mouse lethal dose (50 percent kill): 2200 mg/kgGISAAA 45(3),79,1980
oral/rabbit lethal dose (50 percent kill): 3200 mg/kgGastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Body temperature decrease		GISAAA 45(3),79,1980
oral/rat lethal dose (50 percent kill): 111 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes		NTIS** OTS0542011
skin/rabbit lethal dose (50 percent kill): 380 mg/kgIAEC** 17JUN1974
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kgTPKVAL 14,80,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHREAY 9,389,1931

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (12 mg/m3)DTLVS* 3,141,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm (24 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (12 mg/m3);KZW 20 ppm (48 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm (24 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (12 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 5 ppm (12 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (12 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (12 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm (24 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (12 mg/m3);short term exposure limit 10 ppm (24 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (12 mg/m3); short term exposure limit 10 ppm (24 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (12 mg/m3); short term exposure limit 10 ppm (24 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 12 mg/m3, MAC(short term exposure limit) 24 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (12 mg/m3);short term exposure limit 10 ppm (25 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (12 mg/m3), KZG-week 10 ppm (24 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 12 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (12 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (12 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (12 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (12 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (12 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 40990; Number of Industries 6; Total Number of Facilities 235; Number of Occupations 7; Total Number of Employees Exposed 8134; Total Number of Female Employees Exposed 3174
National Occupational Hazard Survey 1974Hazard Code 40990; Number of Industries 10; Total Number of Facilities 808; Number of Occupations 14; Total Number of Employees Exposed 13196

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000

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