Registry of Toxic Effects of Chemical Substances (RTECS)
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Malononitrile
RTECS #
OO3150000CAS #
109-77-3Updated
July 2013Molecular Weight
66.07Molecular Formula
C3H2N2Synonyms
CyanoacetonitrileDicyanomethane
Dwumetylosulfotlenku (Polish)
Malonic acid dinitrile
Malonic dinitrile
Methane, dicyano-
Methylene cyanide
Nitril kyseliny malonove (Czech)
Propanedinitrite
RCRA waste number U149
USAF A-4600
USAF KF-19
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 5 mg/24H | severe | 85JCAE -,899,1986 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, melanoma | Inhibitor Concentration (50 percent kill): 24.1 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | FCTOD7 50,2084,2012 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 13 mg/kg | Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | NATUAS 228,1315,1970 |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 10043 µg/kg | Blood: Other changes | TOXID9 3,64,1983 |
| intraperitoneal/rat | lethal dose (50 percent kill): 20550 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | MEPAAX 27,1,1976 |
| intravenous/mouse | lethal dose (50 percent kill): 32 mg/kg | CSLNX* NX#07576 | |
| intravenous/rabbit | lethal dose (50 percent kill): 28 mg/kg | PJPPAA 31,563,1979 | |
| oral/mouse | lethal dose (50 percent kill): 19 mg/kg | KHZDAN 9,50,1966 | |
| oral/rat | lethal dose (50 percent kill): 69.8 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 47,2314,2009 |
| oral/rat | lethal dose (50 percent kill): 14 mg/kg | NTIS** OTS0526327 | |
| skin/rat | lethal dose (50 percent kill): 350 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | MEPAAX 27,1,1976 |
| subcutaneous/Dog | lowest published lethal dose: 6500 µg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Nausea or vomiting | AIPTAK 3,77,1897 |
| subcutaneous/frog | lowest published lethal dose: 95 mg/kg | AIPTAK 3,77,1897 | |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 21 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | MEPAAX 27,1,1976 |
| subcutaneous/mouse | lowest published lethal dose: 8 mg/kg | AIPTAK 3,77,1897 | |
| subcutaneous/pigeon | lowest published lethal dose: 80 mg/kg | AIPTAK 3,77,1897 | |
| subcutaneous/rabbit | lowest published lethal dose: 6 mg/kg | CRSBAW 96,202,1927 | |
| subcutaneous/rat | lethal dose (50 percent kill): 31500 µg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | MEPAAX 27,1,1976 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 28500 mg/kg/19W- intermittent | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | KHZDAN 15,553,1972 |
| oral/rat | lowest published toxic dose: 164 mg/kg/28D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0526327 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.3 mg/m3, Skin, JUN2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALONONITRILE-air | 10H time-weighted average 3 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X5636; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 15; Total Number of Employees Exposed 1233 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division