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Registry of Toxic Effects of Chemical Substances (RTECS)

Mesitylene

RTECS #

OX6825000

CAS #

108-67-8

Updated

July 2013

Molecular Weight

120.21

Molecular Formula

C9H12

Synonyms

1,3,5-Trimethylbenzene
3,5-Dimethyltoluene
Benzene, 1,3,5-trimethyl-
Fleet-X
sym-Trimethylbenzene
Trimethylbenzol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,34,1986
skin /rabbit 20 mg/24H moderate85JCAE -,34,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeintraperitoneal/mouse1800 mg/kgMUREAV 412,299,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 10 ppmPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi		ZUBEAQ 49,265,1956
inhalation/mouse lowest published toxic concentration: 15000 mg/m3Behavioral: Somnolence (general depressed activity)VCVGH* -,175,1990
inhalation/rat Lowest published lethal concentration: 12000 mg/m3/24HVCVGH* -,175,1990
inhalation/rat lethal concentration (50 percent kill): 24000 mg/m3/4HVCVGH* -,175,1990
intraperitoneal/guinea pig lowest published lethal dose: 1303 mg/kgAMIHBC 9,227,1954
oral/mouse lethal dose (50 percent kill): 7000 mg/kgVCVGH* -,175,1990
oral/rat lethal dose (50 percent kill): 5000 mg/kgVCVGH* -,175,1990
oral/rat lethal dose (10 percent kill): 5 mL/kgVCVGH* -,175,1990
subcutaneous/rat lowest published toxic dose: 12 mL/kgBlood: Changes in leukocyte (WBC) countVCVGH* -,175,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/24H/17W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases		GISAAA 44(5),15,1979
inhalation/rat lowest published toxic concentration: 100 ppm/6H/20D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Analgesia

Behavioral: Alteration of operant conditioning		NRTXDN 22,79,2001
inhalation/rat lowest published toxic concentration: 20 mg/m3/16W- continuousKidney, Ureter, and Bladder: Other changes in urine compositionVCVGH* -,176,1990
oral/rat lowest published toxic dose: 2100 mg/kg/14D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)NTIS** OTS0558836
oral/rat lowest published toxic dose: 54 gm/kg/90D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P		NTIS** OTS0558838
subcutaneous/rabbit lowest published toxic dose: 0.3 mL/kg/3D- intermittentBlood: Changes in leukocyte (WBC) countVCVGH* -,176,1990

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (100 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (100 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 100 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FRANCEVLE 20 ppm (100 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (100 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 100 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (100 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 25 ppm (120 mg/m3), MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (125 mg/m3);short term exposure limit 35 ppm (170 mg/m3), 2004
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 35 ppm (170 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (100 mg/m3), KZG-week 40 ppm (200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (125 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1998; Number of Industries 4; Total Number of Facilities 495; Number of Occupations 6; Total Number of Employees Exposed 12997; Total Number of Female Employees Exposed 231

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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