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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromochloro-

RTECS #

PA5250000

CAS #

74-97-5; 83847-49-8

Updated

September 201

Molecular Weight

129.39

Molecular Formula

CH2BrCl

Synonyms

Bromochloromethane
Chlorobromomethane
Chlorobromomethane (ACGIH:OSHA)
Fluorocarbon 1011
Halon 1011
Methylene chlorobromide
Mil-B-4394-B
Monochloromonobromomethane
Mono-chloro-mono-bromo-methane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1 µmol/LTECSDY 13,205,1987
mutation in microorganisms/Salmonella typhimurium10 mg/plate (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 13,205,1987
sister chromatid exchangelung/hamster5 µmol/LTECSDY 13,205,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 12030 mg/m3/7HBehavioral: General anesthetic

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea		JIHTAB 29,382,1947
inhalation/rat Lowest published lethal concentration: 28800 ppm/15MBehavioral: General anesthetic

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor		MRLR** #113,1952
inhalation/rat lowest published toxic concentration: 7800 mg/m3/3HBehavioral: General anestheticVCVGH* -,627,1990
inhalation/rat Lowest published lethal concentration: 53000 mg/m3/15MVCVGH* -,627,1990
oral/mouse lethal dose (50 percent kill): 4300 mg/kgBehavioral: General anestheticJIHTAB 29,382,1947
oral/rat lethal dose (50 percent kill): 5 gm/kg34ZIAG -,390,1969
skin/rabbit lethal dose (50 percent kill): >20 gm/kgNTIS** AD-A062-138

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 500 ppm/6H/26W- intermittentNutritional and Gross Metabolic: Changes in: Other metalsJOCMA7 8,251,1966
inhalation/rabbit lowest published toxic concentration: 1000 ppm/7H/16W- intermittentNutritional and Gross Metabolic: Changes in: Other metalsAIHAAP 21,275,1960
inhalation/rat lowest published toxic concentration: 1000 ppm/7H/16W- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Other metals		AIHAAP 21,275,1960
inhalation/rat lowest published toxic concentration: 500 ppm/6H/26W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Other metals		JOCMA7 8,251,1966

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 636,242,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (1050 mg/m3)DTLVS* 3,50,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (1060 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (1050 mg/m3);KZW 800 ppm (4200 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (1075 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (1050 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 200 ppm (1100 mg/m3), short term exposure limit 250 ppm (1300 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 200 ppm (1050 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (1050 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (1050 mg/m3), short term exposure limit 250 ppm (1300 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (1050 mg/m3);short term exposure limit 250 ppm (1300 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (1060 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (1058 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 1000 mg/m3, short term exposure limit 1300 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (1050 mg/m3), KZG-week 400 ppm (2100 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (1050 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (1050 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (1050 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (1050 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (1050 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROBROMOMETHANE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 18250; Number of Industries 1; Total Number of Facilities 35; Number of Occupations 1; Total Number of Employees Exposed 71
National Occupational Hazard Survey 1974Hazard Code 18250; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 56

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
On EPA IRIS database

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