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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, dimethoxy-

RTECS #

PA8750000

CAS #

109-87-5

Updated

September 201

Molecular Weight

76.11

Molecular Formula

C3H8O2

Synonyms

Anesthenyl
Bis(methoxy)methane
Dimethoxymethane
Dimethoxymethane (ACGIH:OSHA)
Dimethyl formal
Dioxapentane
Formal
Formaldehyde dimethylacetal
Formaldehyde methyl ketal
Methoxymethyl methyl ether
Methylal
Methylal (ACGIH:OSHA)
Methylene dimethyl ether
Metylal (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL moderateNTIS** OTS0536049

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 57 gm/m3/7H85JCAE -,259,1986
inhalation/mouse lethal concentration (50 percent kill): 57000 mg/m3/7MVCVGK* -,501,1994
inhalation/rat lethal concentration (50 percent kill): 15000 ppmNPIRI* 1,73,1974
intraperitoneal/rat lowest published lethal dose: 5 gm/kgNTIS** OTS0524346
oral/rabbit lethal dose (50 percent kill): 5708 mg/kgPSEBAA 29,730,1932
oral/rat lethal dose (50 percent kill): 6653 mg/kgGISAAA 11,16,1993
skin/rabbit Lethal dose: >16 mL/kgEye: Iritis

Lung, Thorax, or Respiration: Other changes

Liver: Other changes		NTIS** OTS0536049

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 35100 mg/m3/7H/22D- intermittentBehavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		BJIMAG 8,279,1951
oral/rat lowest published toxic dose: 7078 mg/kg/3D- intermittentBehavioral: General anesthetic

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Urine volume increased		IJTOFN 19,179,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (3100 mg/m3)DTLVS* 3,154,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (3110 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (3100 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (3155 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1000 ppm (3100 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (3200 mg/m3), short term exposure limit 1300 ppm (4100 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (3100 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (3200 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1000 ppm (3100 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (3100 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (3100 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (3100 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (3112 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 3500 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (3100 mg/m3), KZG-week 2000 ppm (6200 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3100 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (3100 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (3100 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1000 ppm (3160 mg/m3);short term exposure limit 1250 ppm (3950 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (3100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (3100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (3100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (3100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAL-air10H time-weighted average 1000 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 26075; Number of Industries 123; Total Number of Facilities 9104; Number of Occupations 70; Total Number of Employees Exposed 156806; Total Number of Female Employees Exposed 21093
National Occupational Hazard Survey 1974Hazard Code 26075; Number of Industries 5; Total Number of Facilities 122; Number of Occupations 6; Total Number of Employees Exposed 399

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methylal, 1611

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