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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, tetranitro-

RTECS #

PB4025000

CAS #

509-14-8

Updated

September 201

Molecular Weight

196.05

Molecular Formula

CN4O8

Synonyms

NCI-C55947
RCRA waste number P112
Tetan
Tetranitromethane
Tetranitromethane (ACGIH:OSHA)
TNM

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster20 mg/LNTPTR* NTP-TR-386,1990
DNA Damagelung/rat3.9 µmol/L/20HMUREAV 605,94,2006
DNA Damagelung/human1.95 µmol/L/20HMUREAV 605,94,2006
DNA Damageoral/rat65 mg/kgMUREAV 605,94,2006
DNA Damageliver/rat50 µmol/L/3HMUREAV 629,49,2007
DNA Damageliver/rat70 µmol/LMUREAV 368,59,1996
mutation in microorganisms/Salmonella typhimurium2 µg/plate (+enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms/Escherichia coli500 µg/plate (+enzymatic activation step)SAIGBL 29,34,1987
sister chromatid exchangeovary/hamster1700 µg/LNTPTR* NTP-TR-386,1990

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 500 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma		NTPTR* NTP-TR-386,1990
inhalation/mouse toxic concentration (other than lowest): 500 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma		CALEDQ 57,95,1991
inhalation/mouse lowest published toxic concentration: 30.9 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		NTIS** PB91-113373
inhalation/rat lowest published toxic concentration: 2 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma		NTPTR* NTP-TR-386,1990
inhalation/rat lowest published toxic concentration: 61.8 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		NTIS** PB91-113373
inhalation/rat lowest published toxic concentration: 51.5 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors		NTIS** PB91-113373
inhalation/rat toxic concentration (other than lowest): 2 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma		CALEDQ 57,95,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): 100 ppm/20M85JCAE -,403,1986
inhalation/human lowest published toxic concentration: 0.05 gm/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression		TPKVAL 4,134,1962
inhalation/mouse Lowest published lethal concentration: 0.2 gm/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression		TPKVAL 4,134,1962
inhalation/mouse lethal concentration (50 percent kill): 54.4 ppmENTOX* -,159,2005
inhalation/mouse lowest published toxic concentration: 0.1 gm/m3Vascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema		TPKVAL 4,134,1962
inhalation/mouse lethal concentration (50 percent kill): 54 ppm/4HBlood: Methemoglobinemia- CarboxhemoglobinemiaNTIS** AD-A051-334
inhalation/mouse lethal concentration (50 percent kill): 0.6 gm/m3TPKVAL 4,134,1962
inhalation/rabbit lowest published toxic concentration: 0.1 gm/m3Behavioral: TetanyTPKVAL 4,134,1962
inhalation/rabbit Lowest published lethal concentration: 0.2 gm/m3Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve		TPKVAL 4,134,1962
inhalation/rat lowest published toxic concentration: 0.1 gm/m3Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other		TPKVAL 4,134,1962
inhalation/rat Lowest published lethal concentration: 0.2 gm/m3Brain and Coverings: Other degenerative changesTPKVAL 4,134,1962
inhalation/rat lethal concentration (50 percent kill): 18 ppm/4HBlood: Methemoglobinemia- CarboxhemoglobinemiaAMRL** TR-77-25,1977
inhalation/rat lethal concentration (50 percent kill): 17.5 ppmENTOX* -,159,2005
inhalation/rat Lowest published lethal concentration: 1.5 gm/m3Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema		TPKVAL 4,167,1962
inhalation/rat Lowest published lethal concentration: 0.6 gm/m3/2HTPKVAL 4,134,1962
intraperitoneal/mammal (species unspecified) lowest published lethal dose: 500 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaCOREAF 171,1396,1920
intraperitoneal/mouse lethal dose (50 percent kill): 53 mg/kgKHFZAN 10(6),53,1976
intravenous/mouse lethal dose (50 percent kill): 63100 µg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaAMRL** TR-77-25,1977
intravenous/rat lethal dose (50 percent kill): 12600 µg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaAMRL** TR-77-25,1977
oral/mouse lethal dose (50 percent kill): 375 mg/kgOlfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)		NTIS** AD-A051-334
oral/mouse lethal dose (50 percent kill): 375 mg/kgENTOX* -,159,2005
oral/rat lethal dose (50 percent kill): 130 mg/kgOlfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)		NTIS** AD-A051-334
oral/rat lethal dose (50 percent kill): 130 mg/kgENTOX* -,159,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 25 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-386,1990
inhalation/mouse lowest published toxic concentration: 10 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight		NTPTR* NTP-TR-386,1990
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/7D- intermittentBehavioral: Alteration of classical conditioningTPKVAL 4,134,1962
inhalation/rat lowest published toxic concentration: 6350 ppb/6H/26W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 10,213,1954
inhalation/rat lowest published toxic concentration: 25 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-386,1990
inhalation/rat lowest published toxic concentration: 10 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTPTR* NTP-TR-386,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 65,437,1996
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 65,437,1996
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 65,437,1996
TOXICOLOGY REVIEWENTOX* -,159,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (8 mg/m3)DTLVS* 3,254,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (8 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.005 ppm (0.04 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.04 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.05 ppm (0.41 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (8 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.04 mg/m3), NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (8 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (8 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (8 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,005 ppm (0,04 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.04 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 ppm (0.4 mg/m3);short term exposure limit 0.1 ppm (0.8 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (8 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (8 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (8 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (8 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (8 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRANITROMETHANE-air10H time-weighted average 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X7237; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1445; Total Number of Female Employees Exposed 230

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Tetranitromethane, 3513
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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