Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-

RTECS #

PB9800000

CAS #

57-74-9; 39400-80-1; 53637-13-1

Updated

December 2013

Molecular Weight

409.76

Molecular Formula

C10H6Cl8

Synonyms

1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane
1,2,4,5,6,7,8,8-Octachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indaan (Dutch)
1,2,4,5,6,7,8,8-Octachlor-2,3,3a,4,7,7a-hexahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachlor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indan (German)
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-hexahydro-4,7-methylene indane
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane
1,2,4,5,6,7,8,8-Octahydro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindan
1,2,4,5,6,7,8,8-Ottochloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indano (Italian)
4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-
Aspon-chlordane
BELT
CD 68
Chloordaan (Dutch)
Chlor KIL
Chlordan
Chlordane
Chlordane (ACGIH:OSHA)
Chlorindan
Chlorodane
Chlortox
Clordan (Italian)
Clordano
Cortilan-neu
Dichlorochlordene
Dowchlor
ENT 25,552-X
ENT 9,932
HCS 3260
Kilex lindane
Kypchlor
Latka 1068 (Czech)
M 140
NCI-C00099
Octachlor
Octachloro-4,7-methanohydroindane
Octachloro-4,7-methanotetrahydroindane
Octachlorodihydrodicyclopentadiene
Octa-klor
Oktaterr
OMS 1437
Ortho-klor
RCRA waste number U036
SD 5532
Shell SD-5532
Starchlor
Synklor
TAT chlor 4
Termi-ded
Topichlor 20
Topiclor
Topiclor 20
Toxichlor
Unexan-koeder
Velsicol 1068

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse10 mg/kgMUREAV 301,33,1993
morphological transformoral/rat1260 mg/kg/6WCRNGDP 9,387,1988
mutation in mammalian somatic cellslung/hamster10 µmol/LCBINA8 19,369,1977
other mutation test systemsoral/mouse35 mg/kgMUREAV 343,157,1995
phage inhibition capacity/Escherichia coli3050 µmol/LMUREAV 182,193,1987
sister chromatid exchangemultiple/other fish54 pmol/LMUREAV 118,61,1983
sister chromatid exchangelymphocyte/human10 µmol/LARTODN 52,221,1983
Unscheduled DNA Synthesisfibroblast/human1 µmol/LMUREAV 42,161,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 3360 µg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic		JEPTDQ 2(2),357,1978
oral/mouse 152 mg/kg (1-19D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTXAPA9 62,402,1982
oral/mouse 7 mg/kg (15-21D pregnant)Reproductive: Effects on newborn: BehavioralBJPCBM 49,311,1973
oral/mouse 3040 µg/kg (1-19D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicENVRAL 35,204,1984
oral/mouse 2625 mg/kg (5W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		TOLED5 115,1,2000
unreported route/mouse 168 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Delayed effectsAPTOD9 19,A18,1980
unreported route/mouse 168 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTJADAB 19,23A,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2020 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		NCITR* NCI-TR-8,1977
oral/mouse toxic dose: 3780 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		NCITR* NCI-TR-8,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 24 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 39 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 15 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 47 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 4 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 247,10,2010
inhalation/cat lethal concentration (50 percent kill): 100 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement		GTPZAB 8(4),30,1964
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): >20 gm/m3/4HPEMNDP 9,139,1991
intraperitoneal/mouse lowest published lethal dose: 240 mg/kgTXAPA9 23,288,1972
intraperitoneal/rat lethal dose (50 percent kill): 343 mg/kgTXAPA9 32,443,1975
intraperitoneal/rat lowest published toxic dose: 25 mg/kgBiochemical: Metabolism (intermediary): OtherENDOAO 82,406,1968
intravenous/mouse lethal dose (50 percent kill): 100 mg/kgCSLNX* NX#04876
intravenous/rabbit lowest published lethal dose: 10 mg/kgAIHOAX 1,13,1950
oral/cat lethal dose (50 percent kill): 100 mg/kgVCVGH* -,565,1990
oral/chicken lethal dose (50 percent kill): 220 mg/kgPCOC** -,226,1966
oral/domestic animal lethal dose (50 percent kill): 50 mg/kgYKYUA6 32,471,1981
oral/duck lethal dose (50 percent kill): 1200 mg/kgDOEAAH 35,25,1979
oral/hamster lethal dose (50 percent kill): 1720 mg/kgEJTXAZ 7,159,1974
oral/human lowest published lethal dose: 29 mg/kgLiver: Fatty liver degenerationCMEP** -,1,1956
oral/mammal (species unspecified) lethal dose (50 percent kill): 180 mg/kgPCOC** -,226,1966
oral/man lowest published toxic dose: 3071 µg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting		JTCTDW 20,291,1983
oral/mouse lethal dose (50 percent kill): 145 mg/kgARSIM* 20,19,1966
oral/rabbit lethal dose (50 percent kill): 100 mg/kgPCOC** -,226,1966
oral/rat lethal dose (50 percent kill): 200 mg/kgARZNAD 17,614,1967
oral/rat lethal dose (50 percent kill): 200 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		TAEHC* VI:34 ,1,1984
oral/woman lowest published lethal dose: 120 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Gastrointestinal: Gastritis		CMEP** -,1,1956
skin/human lowest published lethal dose: 428 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia		34ZIAG -,648,1969
skin/rabbit lethal dose (50 percent kill): 780 mg/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 690 mg/kgJAVMA4 157,1835,1970
unreported route/human lowest published lethal dose: 25 mg/kg/24HTAEHC* VI:34 ,1,1984
unreported route/man lowest published lethal dose: 118 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 28200 µg/m3/8H/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)		JTEHD6 28,327,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/8H/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Ca		JTEHD6 28,327,1989
intraperitoneal/rat lowest published toxic dose: 125 mg/kg/5D- intermittentLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other		ENDOAO 82,406,1968
intraperitoneal/rat lowest published toxic dose: 500 mg/kg/10D- intermittentEndocrine: Androgenic

Endocrine: Estrogenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		CLPTAT 14,727,1976
oral/rat lowest published toxic dose: 7 mg/kg/28D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 60,22,2001
oral/rat lowest published toxic dose: 168 mg/kg/21D- intermittentEndocrine: Other changes

Blood: Changes in spleen		TOXID9 1,54,2001
oral/rat lowest published toxic dose: 21 mg/kg/21D- intermittentLiver: Other changes

Liver: Changes in liver weight		TOXID9 1,54,2001
oral/rat lowest published toxic dose: 176 mg/kg/22D- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold		TOXID9 60,233,2001
oral/rat lowest published toxic dose: 176 mg/kg/22D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,233,2001
oral/rat lowest published toxic dose: 44 mg/kg/22D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 60,233,2001
oral/rat lowest published toxic dose: 22 mg/kg/22D- intermittentLiver: Changes in liver weightTOXID9 60,233,2001
oral/rat lowest published toxic dose: 44 mg/kg/22D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight		TOXID9 60,233,2001
oral/rat lowest published toxic dose: 112 mg/kg/14D- intermittentBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands		TOXID9 60,247,2001
oral/rat lowest published toxic dose: 112 mg/kg/14D- intermittentEndocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TOXID9 60,247,2001
oral/rat lowest published toxic dose: 224 mg/kg/14D- intermittentLung, Thorax, or Respiration: Respiratory depressionTOXID9 60,247,2001
oral/rat lowest published toxic dose: 28 mg/kg/14D- intermittentEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOXID9 60,247,2001
oral/rat lowest published toxic dose: 504 mg/kg/12W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		APTOD9 19,A99,1980
oral/rat lowest published toxic dose: 410 mg/kg/39W- continuousLiver: Other changesAMPLAO 64,614,1957
oral/rat lowest published toxic dose: 660 mg/kg/15D- intermittentBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 7,197,1953
oral/rat lowest published toxic dose: 6512 mg/kg/58W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AMIHBC 7,197,1953
oral/rat lowest published toxic dose: 5475 mg/kg/2Y- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 6,357,1952

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,146,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 53,115,1991
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWENTOX* -,540,2005
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWIMEMDT 79,411,
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNTAPM* -,711,1995
TOXICOLOGY REVIEWREPTED 31,327,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,96,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,44,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, short term exposure limit 3 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, short term exposure limit 2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORDANE-air10H Carcinogen time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100111/AS)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-8,1977
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-8,1977
NIOSH Analytical Method, 1994: Chlordane, 5510
On EPA IRIS database
OSHA ANALYTICAL METHOD #67

Follow NIOSH

NIOSH Homepage

TOP