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Registry of Toxic Effects of Chemical Substances (RTECS)

Methylamine

RTECS #

PF6300000

CAS #

74-89-5

Updated

September 201

Molecular Weight

31.07

Molecular Formula

CH5N

Synonyms

Aminomethane
Carbinamine
Mercurialin
Methanamine (9CI)
Methylamine (ACGIH:OSHA)
Methylaminen (Dutch)
Metilamine (Italian)
Metyloamina (Polish)
Monomethylamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 40% severeENTOX* 86,-,2005
eye /rabbit 5% mildENTOX* 86,-,2005
skin /guinea pig 100 mg open irritation test severeCODEDG 6,140,1980
skin /rabbit 40% severeENTOX* 86,-,2005

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testinhalation/rat10 µg/m3GISAAA 46(5),7,1981
mutation in mammalian somatic cellslymphocyte/mouse3 mmol/LMUREAV 174,285,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 0.4 gm/m3TPKVAL 7,56,1965
inhalation/human lowest published toxic concentration: 0.01 gm/m3Behavioral: Alteration of classical conditioningTPKVAL 7,56,1965
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 2400 mg/m3TPKVAL 14,80,1975
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 3.7 gm/m3Eye: Conjunctiva irritationTPKVAL 7,56,1965
inhalation/mouse lethal concentration (50 percent kill): 2400 mg/m3/2HENTOX* -,86,2005
inhalation/rat lethal concentration (50 percent kill): 448 ppm/2.5HEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Skin: After systemic exposure: Dermatitis, irritative		JEBIDP 13,273,1992
inhalation/rat lethal concentration (50 percent kill): 448 ppm/2.5HENTOX* -,86,2005
intracerebral/mouse lowest published toxic dose: 88.8 ng/kgBrain and Coverings: Other degenerative changes

Behavioral: Food intake (animal)		BJPCBM 142,381,2004
intracerebral/rat lowest published toxic dose: 78.95 µg/kgBrain and Coverings: Other degenerative changes

Behavioral: Food intake (animal)		BJPCBM 150,1003,2007
intracerebral/rat lowest published toxic dose: 315.79 µg/kgBehavioral: Food intake (animal)

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites		BJPCBM 150,1003,2007
oral/rat lethal dose (50 percent kill): 100 mg/kgENTOX* -,86,2005
subcutaneous/guinea pig lowest published lethal dose: 200 mg/kgHBAMAK 4,1289,1935
subcutaneous/mouse lowest published lethal dose: 2500 mg/kg85KYAH 11,949,1989
subcutaneous/rat lowest published lethal dose: 200 mg/kgHBAMAK 4,1289,1935
unreported route/mouse lethal dose (50 percent kill): 317 mg/kgHBPTO* 1,825,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 750 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight		INHTE5 2,29,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHREAY 9,389,1931
TOXICOLOGY REVIEWENTOX* -,86,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (12 mg/m3)DTLVS* 3,156,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (13 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (12 mg/m3);KZW 10 ppm (12 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (6.6 mg/m3), short term exposure limit 15 ppm (19 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (6.4 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 10 ppm (13 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 10 ppm (13 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (6.4 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (13 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (12 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (12 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (13 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (6,4 mg/m3); short term exposure limit 15 ppm (19 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 15 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (13 mg/m3);short term exposure limit 20 ppm (25 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 ppm (12 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 6.4 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (12 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (12 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (12 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (12 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (12 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAMINE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46470; Number of Industries 6; Total Number of Facilities 197; Number of Occupations 24; Total Number of Employees Exposed 10890; Total Number of Female Employees Exposed 1411
National Occupational Hazard Survey 1974Hazard Code 46470; Number of Industries 5; Total Number of Facilities 175; Number of Occupations 9; Total Number of Employees Exposed 1098

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #40

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