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Registry of Toxic Effects of Chemical Substances (RTECS)

Mineral oil

RTECS #

PY8030000

CAS #

8012-95-1; 39355-35-6; 79956-36-8; 83046-05-3

Updated

December 2012

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Adepsine oil
Alboline
Bayol 55
Bayol F
Blandlube
Crystol 325
Crystosol
Glymol
Kondremul
Liquid paraffin
Neo-cultol
Nujol
Oil mist, mineral
Oil mist, mineral (ACGIH:OSHA)
Paraffin oil
Paroleine
Petrogalar
Primol 355
Primol D
Saxol
USP mineral oil

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg moderateAJOPAA 29,1363,1946
skin /guinea pig 100 mg/24H mildCTOIDG 94(8),41,1979
skin /rabbit 100 mg/24H mildCTOIDG 94(8),41,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/man lowest published toxic concentration: 5 mg/m3/5Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Tumorigenic effects: Testicular tumors		JJOMDZ 23,333,1981
intraperitoneal/mouse lowest published toxic dose: 14 gm/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Lung, Thorax, or Respiration: Bronchogenic carcinoma		NATUAS 193,1086,1962
intraperitoneal/mouse toxic dose: 60 gm/kg/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors		CNREA8 38,703,1978
intraperitoneal/mouse toxic dose: 60 gm/kg/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		IMMUAM 17,481,1969
intraperitoneal/mouse toxic dose: 50 gm/kg/9W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors

Immunological Including Allergic: Decreased immune response		IJCNAW 6,422,1970
intraperitoneal/mouse toxic dose: 72 gm/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors		JOIMA3 92,747,1962
skin/mouse lowest published toxic dose: 332 gm/kg/20W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors		ANYAA9 132,439,1965

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4 gm/m3/4HBehavioral: Somnolence (general depressed activity)

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOXID9 -,221,2008
intraperitoneal/mouse lowest published toxic dose: 20 mL/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Autoimmune (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		BIPHEX 58,325,2004
oral/mouse lethal dose (50 percent kill): 22 gm/kgATXKA8 30,243,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 70 mg/m3/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes		VCVPS* -,91,1998
oral/rat lowest published toxic dose: 900 mg/kg/90D- continuousImmunological Including Allergic: Decrease in humoral immune responseTOXID9 60,30,2001
skin/mouse lowest published toxic dose: 20800 µL/kg/13W- intermittentLiver: Changes in liver weightNTPTR* NIH-92-3340
skin/rat lowest published toxic dose: 5200 µL/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight		NTPTR* NIH-92-3340

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWPAASAH 54,171,1959
TOXICOLOGY REVIEWBIPHEX 58,325,2004
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWBPRCG* 21,849,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,225,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3 (particulate)DTLWS* 3,25,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 3 mg/m3 (mist), 1 carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, short term exposure limit 10 ppm, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code T1542; Number of Industries 275; Total Number of Facilities 49328; Number of Occupations 178; Total Number of Employees Exposed 1100229; Total Number of Female Employees Exposed 433405
National Occupational Hazard Survey 1974Hazard Code T1542; Number of Industries 3; Total Number of Facilities 22; Number of Occupations 7; Total Number of Employees Exposed 698

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oil mist, mineral, 5026
NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen

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