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Registry of Toxic Effects of Chemical Substances (RTECS)

Naphthalene, 2-nitro-

RTECS #

QJ9760000

CAS #

581-89-5

Updated

July 2013

Molecular Weight

173.18

Molecular Formula

C10H7NO2

Synonyms

2-Nitronaphthalene
beta-Nitronaphthalene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Escherichia coli5 mg/LJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae1 pphJJIND8 62,901,1979
host-mediated assaySalmonella typhimurium/mouse125 mg/kgJJIND8 62,911,1979
micronucleus testlymphocyte/human60 mg/LMUREAV 393,23,1997
morphological transformembryo/hamster1 mg/LIJCNAW 19,642,1977
mutation in mammalian somatic cellslymphocyte/human80 mg/LMUREAV 393,23,1997
mutation in microorganisms/Salmonella typhimurium3 µg/plate (+enzymatic activation step)MUREAV 216,211,1989
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)PNASA6 72,5135,1975
other mutation test systems/Salmonella typhimurium6 mg/LMUREAV 192,239,1987
specific locus testother cell types/human462 µmol/L/10HMUREAV 472,93,2000
specific locus testskin/mouse56000 mg/kg/28D-continuousMUREAV 608,88,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 2400 mg/kg/34W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		XPHCI* 17DEC1976
oral/monkey lowest published toxic dose: 340 gm/kg/5Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		GANNA2 61,79,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1300 mg/kgJJIND8 62,911,1979
oral/rabbit lethal dose (50 percent kill): 2650 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Methemoglobinemia- Carboxhemoglobinemia		34ZIAG -,428,1969
oral/rat lethal dose (50 percent kill): 4400 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		34ZIAG -,428,1969

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 46,303,1989
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 46,303,1989
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 46,303,1989
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.035 ppm (0.25 mg/m3);KZW 0.14 ppm (1 mg/m3), 2007
Occupational Exposure Limit-HUNGARYceiling concentration 0.25 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-SWITZERLANDMAK-week 0.035 ppm (0.25 mg/m3), carc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-NITRONAPHTHALENE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Host-mediated assay
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976

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