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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Naphthylamine

RTECS #

QM1400000

CAS #

134-32-7

Updated

September 201

Molecular Weight

143.20

Molecular Formula

C10H9N

Synonyms

1-Aminonaftalen (Czech)
1-Aminonaphthalene
1-Naftilamina (Spanish)
1-Naftylamin (Czech)
1-Naftylamine (Dutch)
1-Naphthylamin (German)
Alfanaftilamina (Italian)
alfa-Naftyloamina (Polish)
alpha-Naftalamin (Czech)
alpha-Naftylamin (Czech)
alpha-Naphthylamine (DOT:OSHA)
C.I. Azoic Diazo Component 114
Fast Garnet B Base
Fast Garnet Base B
Naphthalidam
Naphthalidine
RCRA waste number U167

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisliver/rat25 mg/LPMRSDJ 1,570,1981
Cytogenetic Analysisfibroblast/hamster60 mg/L/48HMUREAV 48,337,1977
DNA adductoral/Dog60 µmol/kgEVHPAZ 49,125,1983
DNA Damageintraperitoneal/mouse150 mg/kgCRNGDP 2,265,1981
DNA Damageoral/mouse400 mg/kgMUREAV 440,1,1999
DNA Damageintraperitoneal/rat2790 µmol/kgCRNGDP 2,1317,1981
DNA Damageliver/rat3 mmol/LSinJF# 26OCT1982
DNA Damage/Bacillus subtilis2 mg/discPMRSDJ 1,175,1981
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
DNA repair/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,502,1981
DNA repair/Escherichia coli25 mg/LJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae50 ppmPMRSDJ 1,481,1981
host-mediated assaySalmonella typhimurium/mouse167 mg/kgJJIND8 62,911,1979
host-mediated assayEscherichia coli/mouse33 mg/kgMUREAV 272,161,1992
micronucleus testother cell types/mouse229.16 mg/L/4H (+enzymatic activation step)MUTAEX 14,403,1999
morphological transformembryo/hamster100 mg/LAETODY 1,241,1980
morphological transformmammary gland/mouse1 µg/LCNREA8 39,1784,1979
morphological transformother cell types/human65 mg/LITCSAF 17,719,1981
morphological transformoral/rat400 mg/kgCNREA8 40,1157,1980
mutation in mammalian somatic cellslymphocyte/mouse1700 µg/LPMRSDJ 1,580,1981
mutation in microorganisms/Salmonella typhimurium0.9 µmol/L/16H (+enzymatic activation step)EMMUEG 46,126,2005
mutation in microorganisms/Saccharomyes cerevisiae10 mg/L/16HMUTAEX 20,105,2004
mutation in microorganisms/Bacillus subtilis5 gm/L (-enzymatic activation step)MUREAV 42,19,1977
mutation in microorganisms/Salmonella typhimurium50 µg/plate (+enzymatic activation step)PMRSDJ 1,261,1981
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)ENMUDM 6,497,1984
other mutation test systems/Escherichia coli35 nmol/tubeMUREAV 147,79,1985
phage inhibition capacity/Escherichia coli250 mg/LCNREA8 41,532,1981
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeintraperitoneal/mouse38 mg/kgMUREAV 108,225,1983
specific locus testovary/hamster10 mg/LPMRSDJ 1,594,1981
sperm morphologyintraperitoneal/mouse1260 mg/kg/5D- intermittentCMMUAO 5,257,1978
Unscheduled DNA Synthesisliver/hamster50 µmol/LENMUDM 6,1,1984
Unscheduled DNA Synthesisfibroblast/human10 mg/LPMRSDJ 1,528,1981
Unscheduled DNA Synthesisliver/rat700 µmol/LCNREA8 42,3010,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 1300 mg/kg/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia		CNREA8 28,535,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 4.1 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lethal dose (50 percent kill): 96 mg/kgPMRSDJ 1,682,1981
oral/mammal (species unspecified) lowest published lethal dose: 4 gm/kgJIDHAN 13,87,1931
subcutaneous/rabbit lowest published lethal dose: 300 mg/kgBehavioral: Tremor

Behavioral: Muscle weakness		XPHBAO 271,174,1941

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 4,87,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 4,87,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,260,1987
TOXICOLOGY REVIEWKHZHAZ 12(2),85,1976
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 578,88,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDskin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted averageDTLWS* 3,24,1973
Occupational Exposure Limit-AUSTRIATRK-TMW 0.17 ppm (1 mg/m3);KZW 0.68 ppm (4 mg/m3), inhal, skin, 2007
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0 mg/m3, MAC(short term exposure limit) 0 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1104CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1004,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-NAPHTHYLAMINE-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1004NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84304; Number of Industries 1; Total Number of Facilities 268; Number of Occupations 5; Total Number of Employees Exposed 2132; Total Number of Female Employees Exposed 1796
National Occupational Hazard Survey 1974Hazard Code 84304; Number of Industries 2; Total Number of Facilities 66; Number of Occupations 2; Total Number of Employees Exposed 610

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthylamines, 5518
OSHA ANALYTICAL METHOD #93

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