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Registry of Toxic Effects of Chemical Substances (RTECS)

Nickel carbonyl

RTECS #

QR6300000

CAS #

13463-39-3

Updated

September 201

Molecular Weight

170.75

Molecular Formula

C4NiO4

Synonyms

Nichel tetracarbonile (Italian)
Nickel carbonyl (ACGIH:OSHA)
Nickel carbonyle (French)
Nickel tetracarbonyl
Nickel tetracarbonyle (French)
Nikkeltetracarbonyl (Dutch)
RCRA waste number P073
Tetracarbonyl nickel

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 60 mg/m3/15M (8D pregnant)Reproductive: Specific developmental abnormalities: Eye, earTXAPA9 45,345,1978
inhalation/rat 120 mg/m3/15M (8D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		TXAPA9 45,345,1978
inhalation/rat 160 mg/m3/15M (7D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)SCIEAS 203,550,1979
inhalation/hamster 60 mg/m3/15M (5D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Other developmental abnormalities		NTIS** DOE/EV/03140-5
inhalation/hamster 60 mg/m3/15M (5D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)NTIS** DOE/EV/03140-5
inhalation/hamster 60 mg/m3/15M (4D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Respiratory system		48ECAY 3,301,1980
intravenous/rat 25 mg/kg (7D pregnant)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		50WKA3 -,399,1983
intravenous/rat 25 mg/kg (7D pregnant)Reproductive: Effects on embryo or fetus: Fetal death50WKA3 -,399,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 250 mg/m3/30M/1YTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		AJCPAI 35,203,1961
inhalation/rat toxic concentration (other than lowest): 4 ppm/30M/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		AJPAA4 46,1027,1965
intravenous/rat lowest published toxic dose: 54 mg/kg/20W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors		CNREA8 32,2253,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): 1890 mg/m3/30MEQSSDX 1,1,1975
inhalation/cat lethal concentration (50 percent kill): 1900 mg/m3/30MLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight		VCVN5* -,501,1989
inhalation/Dog Lowest published lethal concentration: 360 ppm/90MJOHYAY 7,525,1907
inhalation/human Lowest published lethal concentration: 0.003 pph/1MLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory obstruction

Kidney, Ureter, and Bladder: Renal function tests depressed		VCVN5* -,503,1989
inhalation/human lowest published toxic concentration: 7 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase		GISAAA 22(11),30,1957
inhalation/human Lowest published lethal concentration: 30 ppm/30MAEHLAU 23,373,1971
inhalation/mouse lethal concentration (50 percent kill): 0.01 gm/m3/2HTPKVAL 9,7,1967
inhalation/mouse lethal concentration (50 percent kill): 1.4 ppm/2HTPKVAL 9,7,1967
inhalation/mouse Lowest published lethal concentration: 0.04 gm/m3/2HLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition		TPKVAL 10,144,1968
inhalation/mouse lethal concentration (50 percent kill): 67 mg/m3/30MLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight		VCVN5* -,501,1989
inhalation/mouse lethal concentration (50 percent kill): 67 mg/m3/30MLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes		AMIHBC 8,48,1953
inhalation/rabbit Lowest published lethal concentration: 300 mg/m3/30MYAKUD5 22,455,1980
inhalation/rat lethal concentration (50 percent kill): 873 mg/m3/30MLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight		VCVN5* -,501,1989
inhalation/rat lethal concentration (50 percent kill): 151 mg/m3/2HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight		VCVN5* -,501,1989
inhalation/rat lethal concentration (50 percent kill): 81.5 mg/m3/4HLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight		VCVN5* -,501,1989
inhalation/rat lethal concentration (50 percent kill): 35 ppm/30MAJCPAI 26,107,1956
intraperitoneal/rat lethal dose (50 percent kill): 39 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AEHLAU 14,604,1967
intravenous/rat lethal dose (50 percent kill): 64 mg/kgBiochemical: Metabolism (intermediary): OtherRCOCB8 2,545,1971
skin/rabbit lowest published toxic dose: 0.1 mL/kgBehavioral: Somnolence (general depressed activity)

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Respiratory stimulation		TPKVAL 10,144,1968
subcutaneous/rat lethal dose (50 percent kill): 63 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AEHLAU 14,604,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2500 µg/m3/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL (10),144,1968
inhalation/rat lowest published toxic concentration: 0.0005 gm/m3/14D- intermittentSkin and Appendages: Other: Breast

Reproductive: Tumorigenic effects: Ovarian tumors

Reproductive: Tumorigenic effects: Uterine tumors		TPKVAL 10,144,1968
inhalation/rat lowest published toxic concentration: 30 mg/m3/30M/52W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHAB 16,480,1957
inhalation/rat lowest published toxic concentration: 5.8 mg/m3/4H/3W- intermittentLung, Thorax, or Respiration: Respiratory depression

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVN5* -,504,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppm(Ni)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg(Ni)/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMSUDL 7,264,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 49,257,1990
TOXICOLOGY REVIEWACLSCP 3,156,1973
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEWFEPRA7 35,89,1976
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEW85DHAX Ni,168,1975
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEWDICHAK 54,527,1968
TOXICOLOGY REVIEWCTOXAO 12,601,1978
TOXICOLOGY REVIEWCREOH* 42,35,2002
TOXICOLOGY REVIEWENTOX* -,220,2005
TOXICOLOGY REVIEWMUREAV 533,92,2003
TOXICOLOGY REVIEWHBTME* ,743,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDHUMAN CARCINOGENDTLWS* 3,24,1973
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.001 ppm (0.007 mg/m3)DTLWS* 3,24,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.007 ppm (0.001 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.12 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.05 ppm (0.35 mg/m3);KZW 0.2 ppm (1.4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.12 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 ppm (0.007 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.001 ppm (0.007 mg/m3), short term exposure limit 0.003 ppm (0.021 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 ppm (0.12 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg/m3, short term exposure limit 0.15 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.001 ppm (0.007 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.001 ppm (0.007 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.001 ppm (0.007 mg(Ni)/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 ppm (0.35 mg(Ni)/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.12 mg(Ni)/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 ppm (0.007 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 ppm (0,35 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.003 mg/m3, MAR2004
Occupational Exposure Limit-SWEDENtime-weighted average 0.001 ppm (0.007 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Ni)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.35 mg/m3), skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.35 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMshort term exposure limit 0.1 ppm (0.24 mg(Ni)/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.001 ppm (0.007 mg(Ni)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL CARBONYL-air10H Carcinogen time-weighted average 0.001 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nickel carbonyl, 6007
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
On EPA IRIS database

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