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Registry of Toxic Effects of Chemical Substances (RTECS)

Nonane

RTECS #

RA6115000

CAS #

111-84-2

Updated

September 201

Molecular Weight

128.29

Molecular Formula

C9H20

Synonyms

n-Nonane
Nonane (ACGIH)
Shellsol 140

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /pig 250 µL/24H mildTXCYAC 161,1,2001
skin /rat 300 µL/4D open irritation test moderateTIHEEC 20,109,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 3200 ppm/4HTXAPA9 44,53,1978
inhalation/rat lethal concentration (50 percent kill): 17000 mg/m3/4HVCVGH* -,39,1990
intravenous/mouse lethal dose (50 percent kill): 218 mg/kgJPMSAE 67,566,1978
skin/rat lowest published toxic dose: 0.92 mL/kg/2HSkin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TOLED5 185,168,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1600 ppm/6H/13W- intermittentGastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 44,53,1978
inhalation/rat lowest published toxic concentration: 8100 mg/m3/6H/1W- intermittentEye: Conjunctiva irritation

Behavioral: Tremor

Behavioral: Ataxia		VCVGH* -,39,1990
inhalation/rat lowest published toxic concentration: 8400 mg/m3/6H/63D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		VCVGH* -,39,1990
intraperitoneal/rat lowest published toxic dose: 5 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		ENVRAL 22,271,1980
oral/mouse lowest published toxic dose: 90 gm/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight		TOXID9 54,397,2000
oral/rat lowest published toxic dose: 90 gm/kg/90D- intermittentEndocrine: Changes in adrenal weight

Related to Chronic Data: Changes in ovarian weight		TOXID9 54,397,2000
skin/rat lowest published toxic dose: 1200 µL/kg/4D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIHEEC 20,109,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (1050 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (1065 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (1050 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 200 ppm (1100 mg/m3), short term exposure limit 250 ppm (1300 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 200 ppm (1050 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (1100 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (1050 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (1050 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (1050 mg/m3);short term exposure limit 250 ppm (1300 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (1050 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (1049 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 150 ppm (800 mg/m3);short term exposure limit 200 ppm (1100 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (1050 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1050 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NONANE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M4718; Number of Industries 14; Total Number of Facilities 738; Number of Occupations 16; Total Number of Employees Exposed 7277; Total Number of Female Employees Exposed 717
National Occupational Hazard Survey 1974Hazard Code M4718; Number of Industries 2; Total Number of Facilities 57; Number of Occupations 2; Total Number of Employees Exposed 1231

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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