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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pentanol, 4-methyl-

RTECS #

SA7350000

CAS #

108-11-2

Updated

September 201

Molecular Weight

102.20

Molecular Formula

C6H14O

Synonyms

2-Methyl-4-pentanol
3-Mic
4-Methyl-2-pentanol
4-Methylpentanol-2
4-Metilpentan-2-olo (Italian)
4-Pentanol, 2-methyl-
Alcool methyl amylique (French)
Isobutylmethylcarbinol
Isobutylmethylmethanol
MAOH
Methyl amyl alcohol (OSHA)
Methyl isobutyl carbinol
Methyl isobutyl carbinol (ACGIH:OSHA)
Methylisobutyl carbinol
Methyl-isobutylkarbinol (Czech)
Metilamil alcohol (Italian)
MIBC
MIC

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 4.32 mg/m3Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		GISAAA 5,8,1994
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HJIHTAB 31,343,1949
intraperitoneal/mouse lethal dose (50 percent kill): 812 mg/kgSCCUR* -,7,1961
oral/mouse lowest published lethal dose: 1 gm/kgGastrointestinal: Other changesUCPHAQ 2,217,1949
oral/rat lowest published toxic dose: 510 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 136,199,2003
oral/rat lethal dose (50 percent kill): 2590 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 3560 µL/kgAMIHBC 4,119,1951

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppm;short term exposure limit 40 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (100 mg/m3)DTLVS* 3,166,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (104 mg/m3), short term exposure limit 40 ppm (167 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 25 ppm (100 mg/m3);KZW 40 ppm (160 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 25 ppm (106 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 40 ppm (169 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (100 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (110 mg/m3), short term exposure limit 40 ppm (170 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 25 ppm (100 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (85 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (100 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (100 mg/m3), short term exposure limit 40 ppm (165 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (100 mg/m3);short term exposure limit 40 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (104 mg/m3); short term exposure limit 40 ppm (167 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (104 mg/m3); short term exposure limit 40 ppm (167 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 160 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.07 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (110 mg/m3);short term exposure limit 40 ppm (170 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 20 ppm (85 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (106 mg/m3);short term exposure limit 40 ppm (170 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 25 ppm (Sk);short term exposure limit 40 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X3241; Number of Industries 31; Total Number of Facilities 2585; Number of Occupations 33; Total Number of Employees Exposed 26405; Total Number of Female Employees Exposed 2882

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

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