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Registry of Toxic Effects of Chemical Substances (RTECS)

3-Pentanone

RTECS #

SA8050000

CAS #

96-22-0

Updated

September 201

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

DEK
Diethyl ketone
Diethyl ketone (ACGIH)
Diethylcetone (French)
Dimethylacetone
Metacetone
Methacetone
Pentanone-3
Propione

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg moderateUCDS** 4/25/1958
eye /rabbit 100 mg/24H moderate85JCAE -,282,1986
skin /rabbit 410 mg open irritation test mildUCDS** 4/25/1958
skin /rabbit 500 mg/24H mild85JCAE -,282,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae14800 ppmMUREAV 149,339,1985
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae14800 ppmMUREAV 149,339,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAMIHBC 10,61,1954
intraperitoneal/rat lowest published lethal dose: 1250 mg/kgJIHTAB 27,1,1945
intraperitoneal/rat lowest published toxic dose: 302 mg/kgBehavioral: AnticonvulsantBJPCBM 158,872,2009
intravenous/mouse lethal dose (50 percent kill): 513 mg/kgJPMSAE 67,566,1978
oral/mouse lethal dose (50 percent kill): 3100 mg/kgBehavioral: General anesthetic

Behavioral: Ataxia		MTPEEI (4),41,1997
oral/mouse lethal dose (50 percent kill): 3200 mg/kgVCVGK* -,422,1994
oral/rat lethal dose (50 percent kill): 2140 mg/kgUCDS** 4/25/1958
skin/rabbit lethal dose (50 percent kill): 20 mL/kgAMIHBC 10,61,1954
skin/rat lethal dose (50 percent kill): 2100 mg/kgVCVGK* -,422,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 300 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFEREAC 75,8575,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (705 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (700 mg/m3);KZW 400 ppm (1400 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (715 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 300 ppm (1074 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (700 mg/m3), MAY2011
Occupational Exposure Limit-FRANCEVME 200 ppm (705 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (700 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (705 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (705 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (350 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (705 mg/m3); short term exposure limit 300 ppm (1057 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (705 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 705 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (716 mg/m3);short term exposure limit 250 ppm (895 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYL KETONE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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