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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pentanone, 4-hydroxy-4-methyl-

RTECS #

SA9100000

CAS #

123-42-2

Updated

September 201

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

2-Methyl-2-pentanol-4-one
4-Hydroxy-2-keto-4-methylpentane
4-Hydroxy-4-methyl pentan-2-one
4-Hydroxy-4-methyl-2-pentanone
4-Hydroxy-4-methyl-2-pentanone (OSHA)
4-Hydroxy-4-methyl-pentan-2-on (German, Dutch)
4-Hydroxy-4-methylpentanone-2
4-Idrossi-4-metil-pentan-2-one (Italian)
Diacetonalcohol (Dutch)
Diacetonalcool (Italian)
Diacetonalkohol (German)
Diacetone
Diacetone alcohol
Diacetone alcohol (ACGIH:OSHA)
Diacetone-alcool (French)
Diketone alcohol
Pyranton
Tyranton

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 100 ppm/15MJIHTAB 28,262,1946
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 100 µL/24H severeNTIS** OTS0557741
skin /rabbit 10 mg/24H open irritation testJIHTAB 30,63,1948
skin /rabbit 500 mg open irritation test mildUCDS** 6/29/1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 100000 mg/m3/20MEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)		VCVGK* -,445,1994
inhalation/human lowest published toxic concentration: 475 mg/m3Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,445,1994
inhalation/human lowest published toxic concentration: 1900 mg/m3Lung, Thorax, or Respiration: Respiratory depressionVCVGK* -,445,1994
inhalation/human lowest published toxic concentration: 100 ppmEye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting		NPIRI* 1,21,1974
inhalation/human lowest published toxic concentration: 400 ppmLung, Thorax, or Respiration: Other changesNPIRI* 1,21,1974
inhalation/mouse lowest published toxic concentration: 23000 mg/m3Brain and Coverings: Other degenerative changesVCVGK* -,445,1994
inhalation/mouse lowest published toxic concentration: 100000 mg/m3/20MEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)		VCVGK* -,445,1994
inhalation/rabbit lowest published toxic concentration: 100000 mg/m3/20MEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)		VCVGK* -,445,1994
inhalation/rat lowest published toxic concentration: 100000 mg/m3/20MEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)		VCVGK* -,445,1994
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HNTIS** OTS0557741
intramuscular/rabbit lowest published lethal dose: 2792 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression		JPETAB 33,175,1928
intraperitoneal/mouse lethal dose (50 percent kill): 933 mg/kgSCCUR* -,3,1961
intravenous/rabbit lowest published lethal dose: 2792 mg/kgLung, Thorax, or Respiration: Respiratory depressionJPETAB 33,175,1928
intravenous/rat lowest published lethal dose: 3024 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma		JPETAB 33,175,1928
oral/mouse lethal dose (50 percent kill): 3950 mg/kgJAPMA8 45,669,1956
oral/mouse lethal dose (50 percent kill): 3000 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		VCVGK* -,445,1994
oral/rabbit lowest published lethal dose: 4653 mg/kgLung, Thorax, or Respiration: Respiratory depressionJPETAB 33,175,1928
oral/rat lethal dose (50 percent kill): 2520 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Liver: Other changes		NTIS** OTS0557732
oral/rat lethal dose (50 percent kill): 4000 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression		VCVGK* -,445,1994
skin/rabbit lethal dose (50 percent kill): 13500 mg/kgNPIRI* 1,21,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 250 mg/m3/244D- intermittentBrain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above		VCVGK* -,445,1994
inhalation/rat lowest published toxic concentration: 4494 mg/m3/6W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0536235
inhalation/rat lowest published toxic concentration: 1000 mg/m3/60D- intermittentCardiac: Arrythmias (indlucing changes in conduction)VCVGK* -,445,1994
inhalation/rat lowest published toxic concentration: 1000 mg/m3/122D- intermittentBrain and Coverings: Other degenerative changesVCVGK* -,445,1994
inhalation/rat lowest published toxic concentration: 1000 mg/m3/244D- intermittentCardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins		VCVGK* -,445,1994
oral/rabbit lowest published toxic dose: 12 mL/kg/12D- intermittentBehavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVGK* -,445,1994
oral/rat lowest published toxic dose: 1200 mg/kg/30D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)NTIS** OTS0557741

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (240 mg/m3)DTLVS* 3,70,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (238 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (240 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (241 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (240 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm (360 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (240 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 20 ppm (96 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (240 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (240 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (240 mg/m3);short term exposure limit 75 ppm (360 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (238 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (238 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 50 ppm (240 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (96 mg/m3), KZG-week 40 ppm (192 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 120 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (241 mg/m3);short term exposure limit 75 ppm (362 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIACETONE ALCOHOL-air10H time-weighted average 50 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M4016; Number of Industries 194; Total Number of Facilities 20857; Number of Occupations 116; Total Number of Employees Exposed 264662; Total Number of Female Employees Exposed 67291
National Occupational Hazard Survey 1974Hazard Code M4016; Number of Industries 191; Total Number of Facilities 20435; Number of Occupations 95; Total Number of Employees Exposed 167915

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

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