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Registry of Toxic Effects of Chemical Substances (RTECS)

3-Penten-2-one, 4-methyl-

RTECS #

SB4200000

CAS #

141-79-7

Updated

September 201

Molecular Weight

98.16

Molecular Formula

C6H10O

Synonyms

2,2-Dimethylvinyl methyl ketone
2-Methyl-2-penten-4-one
2-Methyl-2-pentenone-4
4-Methyl-3-penten-2-on (Dutch, German)
4-Methyl-3-penten-2-one
4-Methyl-3-pentene-2-one
4-Metil-3-penten-2-one (Italian)
Acetone, isopropylidene-
Isobutenyl methyl ketone
Isopropylidene acetone
Mesityl oxide
Mesityl oxide (ACGIH:OSHA)
Mesityloxid (German)
Mesityloxyde (Dutch)
Methyl 2,2-dimethylvinyl ketone
Methyl isobutenyl ketone
Ossido di mesitile (Italian)
Oxyde de mesityle (French)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 25 ppm/15MJIHTAB 28,262,1946
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
skin /rabbit 430 mg open irritation test mildUCDS** 11/3/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 500 ppm/8HLung, Thorax, or Respiration: Other changesJIHTAB 24,46,1942
inhalation/human lowest published toxic concentration: 100 mg/m3/15MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough		VCVGK* -,434,1994
inhalation/human lowest published toxic concentration: 25 ppmEye: Conjunctiva irritationJIHTAB 28,262,1946
inhalation/mouse lethal concentration (50 percent kill): 10 gm/m3/2H85GMAT -,80,1982
inhalation/mouse lowest published toxic concentration: 20000 mg/m3Behavioral: General anestheticVCVGK* -,434,1994
inhalation/rat Lowest published lethal concentration: 4000 mg/m3/8HVCVGK* -,434,1994
inhalation/rat lethal concentration (50 percent kill): 9 gm/m3/4H85GMAT -,80,1982
intraperitoneal/mouse lethal dose (50 percent kill): 354 mg/kgSCCUR* -,6,1961
oral/mammal (species unspecified) lethal dose (50 percent kill): 710 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 710 mg/kg85GMAT -,80,1982
oral/rabbit lethal dose (50 percent kill): 1 gm/kg85INA8 6,896,1991
oral/rat lethal dose (50 percent kill): 1120 mg/kg85INA8 6,896,1991
skin/rabbit lethal dose (50 percent kill): 5150 mg/kgNPIRI* 1,71,1974
subcutaneous/frog lowest published lethal dose: 1400 mg/kgAEXPBL 56,346,1906
subcutaneous/rabbit lowest published lethal dose: 840 mg/kgAEXPBL 56,346,1906

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 500 ppm/8H/2W- intermittentKidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 24,46,1942
inhalation/rat lowest published toxic concentration: 400 mg/m3/38H- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes		VCVGK* -,435,1994
inhalation/rat lowest published toxic concentration: 2000 mg/m3/38H- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,435,1994
inhalation/rat lowest published toxic concentration: 500 ppm/8H/2W- intermittentKidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 24,46,1942

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 15 ppm;short term exposure limit 25 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (100 mg/m3)DTLVS* 3,152,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 15 ppm (60 mg/m3), short term exposure limit 25 ppm (100 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 25 ppm (100 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 15 ppm (61 mg/m3), short term exposure limit 25 ppm (101 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (40 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (41 mg/m3), short term exposure limit 25 ppm (100 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 15 ppm (60 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (20 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (40 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 15 ppm (60 mg/m3), short term exposure limit 25 ppm (100 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 15 ppm (60 mg/m3); short term exposure limit 25 ppm (100 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 15 ppm (60 mg/m3); short term exposure limit 25 ppm (100 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (20 mg/m3), KZG-week 10 ppm (40 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 60 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MESITYL OXIDE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 45360; Number of Industries 2; Total Number of Facilities 23; Number of Occupations 3; Total Number of Employees Exposed 362; Total Number of Female Employees Exposed 34
National Occupational Hazard Survey 1974Hazard Code 45360; Number of Industries 9; Total Number of Facilities 1062; Number of Occupations 12; Total Number of Employees Exposed 6484

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301

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