Registry of Toxic Effects of Chemical Substances (RTECS)
Phosphine
RTECS #
SY7525000CAS #
7803-51-2Updated
September 201Molecular Weight
34.00Molecular Formula
H3PSynonyms
Fosforowodor (Polish)Gas-Ex-B
Hydrogen phosphide
Phosphine (ACGIH:OSHA)
Phosphorus hydride
Phosphorus trihydride
Phosphorwasserstoff (German)
RCRA waste number P096
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | lymphocyte/human | 1400 ng/L | SCIEAS 246,251,1989 |
micronucleus test | inhalation/mouse | 5 ppm/6H/13W- intermittent | EMMUEG 24,81,1994 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lowest published lethal concentration: 70 mg/m3/2H | VCVN5* -,66,1993 | |
inhalation/guinea pig | Lowest published lethal concentration: 139 mg/m3/4H | VCVN5* -,66,1993 | |
inhalation/human | lowest published toxic concentration: 2 mg/m3 | Olfaction: Change in sensation of smell | VCVN5* -,67,1993 |
inhalation/human | Lowest published lethal concentration: 10 mg/m3 | Olfaction: Change in sensation of smell | VCVN5* -,67,1993 |
inhalation/human | Lowest published lethal concentration: 1000 ppm/5M | TABIA2 3,231,1933 | |
inhalation/mammal (species unspecified) | Lowest published lethal concentration: 1000 ppm/5M | AEPPAE 138,65,1928 | |
inhalation/man | lowest published toxic concentration: 2.7 ppm/20M | Behavioral: Headache Lung, Thorax, or Respiration: Cough Gastrointestinal: Hypermotility, diarrhea | JTCTDW 39,165,2001 |
inhalation/mouse | Lowest published lethal concentration: 380 mg/m3/1H | VCVN5* -,66,1993 | |
inhalation/mouse | Lowest published lethal concentration: 760 mg/m3/35M | VCVN5* -,66,1993 | |
inhalation/mouse | Lowest published lethal concentration: 380 mg/m3/2H | 85GMAT -,75,1982 | |
inhalation/rabbit | Lowest published lethal concentration: 2500 ppm/20M | AEXPBL 27,314,1890 | |
inhalation/rabbit | Lowest published lethal concentration: 139 mg/m3/4H | VCVN5* -,66,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 11 ppm/4H | Lung, Thorax, or Respiration: Dyspnea | AIHAAP 36,452,1975 |
inhalation/rat | Lowest published lethal concentration: 140 mg/m3/4H | VCVN5* -,66,1993 | |
inhalation/woman | lowest published toxic concentration: 2.7 ppm/20M | Behavioral: Headache Lung, Thorax, or Respiration: Cough Gastrointestinal: Hypermotility, diarrhea | JTCTDW 39,165,2001 |
inhalation/woman | lowest published toxic concentration: 242 ppm/30M | Behavioral: Muscle weakness Behavioral: Headache | TIHEEC 18,71,2002 |
intraperitoneal/rat | lowest published toxic dose: 4 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 179,1,2002 |
intraperitoneal/rat | lowest published toxic dose: 4 mg/kg | Cardiac: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOXID9 60,45,2001 |
intraperitoneal/rat | lowest published toxic dose: 4 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Lipids including transport | TOXID9 60,45,2001 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | lowest published toxic concentration: 14 mg/m3/7H/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,67,1989 |
inhalation/mouse | lowest published toxic concentration: 10 ppm/4H/4D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | INHTE5 7,225,1995 |
inhalation/mouse | lowest published toxic concentration: 5 ppm/4H/2W- intermittent | Cardiac: Changes in heart weight Lung, Thorax, or Respiration: Changes in lung weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | INHTE5 7,225,1995 |
inhalation/mouse | lowest published toxic concentration: 5 ppm/6H/4W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in bladder weight | JOCHFV 38,36,1996 |
inhalation/rabbit | lowest published toxic concentration: 14 mg/m3/7H/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,67,1989 |
inhalation/rat | lowest published toxic concentration: 200 µg/m3/24H/6W- continuous | Brain and Coverings: Recordings from specific areas of CNS Blood: Pigmented or nucleated red blood cells Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | GISAAA 49(1),13,1984 |
inhalation/rat | lowest published toxic concentration: 3100 ppb/6H/13W- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count Blood: Changes in platelet count | INHTE5 5,223,1993 |
inhalation/rat | lowest published toxic concentration: 10 ppm/4H/4D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | INHTE5 7,225,1995 |
inhalation/rat | lowest published toxic concentration: 5 ppm/4H/2W- intermittent | Cardiac: Changes in heart weight Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight | INHTE5 7,225,1995 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.3 ppm;short term exposure limit 1 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
TOXICOLOGY REVIEW | NTIS** AD778-725 | |
TOXICOLOGY REVIEW | TIHEEC 18,71,2002 | |
TOXICOLOGY REVIEW | FSINDR 166,190,2007 | |
TOXICOLOGY REVIEW | HUTOX* -,661,1996 | |
TOXICOLOGY REVIEW | HUTOX* -,515,1996 | |
TOXICOLOGY REVIEW | HUTOX* -,561,1996 | |
TOXICOLOGY REVIEW | MUREAV 543,251,2003 | |
TOXICOLOGY REVIEW | MUTAEX 22,161,2007 | |
TOXICOLOGY REVIEW | MUTAEX 26,19,2011 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.3 ppm (0.4 mg/m3) | DTLVS* 3,209,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.3 ppm (0.42 mg/m3), short term exposure limit 1 ppm (1.4 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (0.15 mg/m3);KZW 0.2 ppm (0.3 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.14 mg/m3), MAR2002 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 0.2 ppm (0.28 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.15 mg/m3), MAY2011 | |
Occupational Exposure Limit-EC | time-weighted average 0.14 mg/m3 (0.1 ppm);short term exposure limit 0.28 mg/m3 (0.2 ppm), FEB2006 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.14 mg/m3), short term exposure limit 0.2 ppm (0.28 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.1 ppm (0.13 mg/m3), VLE 0.3 ppm (0.4 mg/m3), FEB2006 | |
Occupational Exposure Limit-GERMANY | MAK 0.1 ppm (0.14 mg/m3), 2011 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.14 mg/m3, short term exposure limit 0.14 mg/m3, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.14 mg/m3), short term exposure limit 0.2 ppm (0.28 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | ceiling concentration 0.3 ppm (0.42 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.3 ppm (0.4 mg/m3), short term exposure limit 1 ppm (1 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.3 ppm (0.4 mg/m3);short term exposure limit 1 ppm (1 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.3 ppm (0.42 mg/m3), short term exposure limit 1 ppm (1.4 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 ppm (0.15 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,3 ppm (0,42 mg/m3); short term exposure limit 1 ppm (1,39 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.8 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 0.1 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.3 ppm (0.4 mg/m3);short term exposure limit 1 ppm (1.4 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 ppm (0.15 mg/m3), KZG-week 0.2 ppm (0.3 mg/m3), JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.4 mg/m3, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.1 ppm (0.14 mg/m3);short term exposure limit 0.2 ppm (0.28 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.3 ppm (0.4 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.3 ppm (0.4 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.3 ppm (0.4 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.3 ppm (0.4 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHINE-air | 10H time-weighted average 0.3 ppm;short term exposure limit 1.0 ppm | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division