Registry of Toxic Effects of Chemical Substances (RTECS)
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Phosphonothioic acid, phenyl-, O-ethyl O-(p-nitrophenyl)ester
RTECS #
TB1925000CAS #
2104-64-5; 65580-81-6Updated
September 201Molecular Weight
323.32Molecular Formula
C14H14NO4PSSynonyms
Benzenephosphonic acid, thiono-, ethyl-p-nitrophenyl esterENT 17,798
EPN
EPN (ACGIH:OSHA)
EPN 300
Ethoxy-4-nitrophenoxyphenylphosphine sulfide
Ethyl p-nitrophenyl benzenethionophosphonate
Ethyl p-nitrophenyl benzenethiophosphate
Ethyl p-nitrophenyl benzenethiophosphonate
Ethyl p-nitrophenyl phenylphosphonothioate
Ethyl p-nitrophenyl thionobenzenephosphate
Ethyl p-nitrophenyl thionobenzenephosphonate
IN-9663-90
O-(4-Nitrophenyl) O-ethyl phenyl thiophosphonate
O-Aethyl-O-(4-nitro-phenyl)-phenyl-monothiophosphonat (German)
O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate
O-Ethyl O-(4-nitrophenyl)benzenethionophosphonate
O-Ethyl O-p-nitrophenyl phenylphosphonothiolate
O-Ethyl O-p-nitrophenyl phenylphosphorothioate
O-Ethyl phenyl p-nitrophenyl thiophosphonate
O-Ethyl-O-((4-nitro-fenyl)-fenyl)-monothiofosfonaat (Dutch)
O-Ethyl-O-p-nitrofenylester kyseliny fenylthiofosfonove (Czech)
O-Etil-O-((4-nitro-fenil)-fenil)-monotiofosfonato (Italian)
OMS 219
Phenol, p-nitro-, O-ester with O-ethyl phenyl phosphonothioate
Phenylphosphonothioate, O-ethyl-O-p-nitrophenyl-
Phenylphosphonothioic acid O-ethyl O-p-nitrophenyl ester
Phenylthiophosphonate de O-ethyle et O-4-nitrophenyle (French)
PIN
Santox
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 µL | moderate | NTIS** OTS0540535 |
| skin /rabbit | 500 µL | moderate | NTIS** OTS0540536 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 132 mg/kg (6-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JPFCD2 20,373,1985 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 106 mg/m3/1H | Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | NTIS** OTS0570820 |
| intraperitoneal/chicken | lethal dose (50 percent kill): 17 mg/kg | BECTA6 18,534,1977 | |
| intraperitoneal/Dog | lowest published lethal dose: 35 mg/kg | JPETAB 112,29,1954 | |
| intraperitoneal/guinea pig | lethal dose (10 percent kill): 14 mg/kg | TXAPA9 8,259,1966 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 8400 µg/kg | IJBBBQ 15,336,1978 | |
| intraperitoneal/rabbit | lowest published lethal dose: 20 mg/kg | JPETAB 112,29,1954 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 7200 µg/kg | APCRAW 4,117,1961 | |
| oral/chicken | lethal dose (50 percent kill): 5 mg/kg | JPFCD2 17,611,1982 | |
| oral/Dog | lethal dose (50 percent kill): 20 mg/kg | PCOC** -,478,1966 | |
| oral/duck | lethal dose (50 percent kill): 3 mg/kg | TXAPA9 20,57,1971 | |
| oral/mouse | lethal dose (50 percent kill): 12200 µg/kg | ABCHA6 26,257,1962 | |
| oral/pigeon | lethal dose (50 percent kill): 4210 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 5 mg/kg | TXAPA9 20,57,1971 | |
| oral/rat | lethal dose (50 percent kill): 7 mg/kg | JPETAB 112,29,1954 | |
| oral/wild bird | lethal dose (50 percent kill): 2370 µg/kg | ASTTA8 (680),157,1979 | |
| skin/cat | lethal dose (50 percent kill): 45 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Ataxia | TOLED5 1000(Sp Iss 1),141,1980 |
| skin/duck | lethal dose (50 percent kill): 400 mg/kg | TXAPA9 47,451,1979 | |
| skin/mouse | lethal dose (50 percent kill): 348 mg/kg | ABCHA6 26,257,1962 | |
| skin/rabbit | lethal dose (50 percent kill): 30 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes | AFDOAQ 16,3,1952 |
| skin/rat | lethal dose (50 percent kill): 25 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | TXAPA9 2,88,1960 |
| subcutaneous/mouse | lethal dose (50 percent kill): 22900 µg/kg | TOIZAG 25,635,1978 | |
| unreported route/rat | lethal dose (50 percent kill): 7 mg/kg | JPETAB 128,289,1960 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/chicken | lowest published toxic dose: 90 mg/kg/90D- intermittent | Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 45,685,1978 |
| oral/Dog | lowest published toxic dose: 35 mg/kg/4W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPETAB 121,96,1957 |
| oral/rat | lowest published toxic dose: 84 mg/kg/8W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPETAB 121,96,1957 |
| oral/rat | lowest published toxic dose: 2700 mg/kg/30D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPETAB 112,29,1954 |
| skin/cat | lowest published toxic dose: 180 mg/kg/90D- intermittent | Spinal Cord: Demyelination Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 68,54,1983 |
| skin/chicken | lowest published toxic dose: 90 mg/kg/90D- intermittent | Behavioral: Ataxia | JTEHD6 16,85,1985 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
| TOXICOLOGY REVIEW | TXAPA9 47,451,1979 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,116,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg/m3 (skin) | DTLVS* 3,99,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.5 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.5 mg/m3, inhal, skin, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPN-air | 10H time-weighted average 0.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: EPN, 5012 | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division