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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, triphenyl ester

RTECS #

TC8400000

CAS #

115-86-6

Updated

September 201

Molecular Weight

326.30

Molecular Formula

C18H15O4P

Synonyms

Celluflex TPP
Disflamoll TP
Phosflex TPP
Reolube TPP
Reomol TPP
TPP
Trifenylfosfat (Czech)
Triphenyl phosphate
Triphenyl phosphate (ACGIH:OSHA)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 4200 mg/m3Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)		GISAAA 39(8),98,1974
intramuscular/rabbit Lethal dose: >1 gm/kgNIHBAZ 160,1,1932
intraperitoneal/cat Lethal dose: >400 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness		AEHLAU 1,33,1960
intraperitoneal/mouse lethal dose (50 percent kill): 1273 mg/kgABCHA6 31,1288,1967
intraperitoneal/rat Lethal dose: >5 gm/kgGastrointestinal: Other changes

Skin and Appendages: Other: Hair		NTIS** OTS0535042
oral/cat lowest published lethal dose: 2 gm/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Muscle weakness		ARZNAD 7,585,1957
oral/chicken lowest published lethal dose: 5 gm/kgSpinal Cord: Other degenerative changesNTIS** OTS0539872
oral/guinea pig Lethal dose: >4 gm/kgAEHLAU 1,33,1960
oral/mouse lethal dose (50 percent kill): 1320 mg/kgOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)		GISAAA 39(8),98,1974
oral/rabbit lowest published lethal dose: 3 gm/kgAEHLAU 1,33,1960
oral/rat lethal dose (50 percent kill): 3500 mg/kgBehavioral: Tremor

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea		ARZNAD 7,585,1957
skin/guinea pig lethal dose (50 percent kill): >4 gm/kgKODAK* 21MAY1971
skin/rabbit lethal dose (50 percent kill): >7900 mg/kgTXAPA9 41,291,1977
subcutaneous/cat lowest published lethal dose: 300 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Muscle weakness		NIHBAZ 160,1,1932
subcutaneous/guinea pig Lethal dose: >3 gm/kgAEHLAU 1,33,1960
subcutaneous/monkey lowest published lethal dose: 500 mg/kgDTLVS* 4,420,1980
subcutaneous/mouse Lethal dose: >3 gm/kgAEHLAU 1,33,1960
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgAEHLAU 1,33,1960
subcutaneous/rat Lethal dose: >3 gm/kgAEHLAU 1,33,1960

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/cat lowest published toxic dose: 600 mg/kg/10D- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Other changes		ARZNAD 7,585,1957
oral/chicken lowest published toxic dose: 25 gm/kg/5D- intermittentSpinal Cord: Other degenerative changes

Behavioral: Ataxia		NTIS** OTS0539873
oral/rat lowest published toxic dose: 65 gm/kg/65D- continuousSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		ARZNAD 7,585,1957
oral/rat lowest published toxic dose: 59353 mg/kg/35D- continuousLiver: Changes in liver weightAEHLAU 1,33,1960
skin/domestic bird lowest published toxic dose: 1200 mg/kg/3D- intermittentSpinal Cord: Other degenerative changes

Behavioral: Ataxia		NEZAAQ 52,281,1997

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 3 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCRTXB2 3,289,1975

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 3 mg/m3DTLVS* 3,272,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 3 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 3 mg/m3;KZW 6 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 3 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 3 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 3 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 3 mg/m3;short term exposure limit 6 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 3 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 3 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 3 mg/m3;short term exposure limit 6 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 3 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 3 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 3 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 3 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIPHENYL PHOSPHATE-air10H time-weighted average 3 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 74635; Number of Industries 51; Total Number of Facilities 2869; Number of Occupations 54; Total Number of Employees Exposed 91754; Total Number of Female Employees Exposed 22800
National Occupational Hazard Survey 1974Hazard Code 74635; Number of Industries 11; Total Number of Facilities 341; Number of Occupations 30; Total Number of Employees Exposed 7631

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038

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