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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O-ethyl O-(4-(methylthio)phenyl) S-propyl ester

RTECS #

TE4165000

CAS #

35400-43-2

Updated

September 201

Molecular Weight

322.46

Molecular Formula

C12H19O2PS3

Synonyms

BAY-NTN-9306
Bolstar
Helothion
NTN 9306
O-Ethyl O-(4-(methylmercapto)phenyl)-S-n-propylphosphorothionothiolate
O-Ethyl O-(4-(methylthio)phenyl) S-propyl phosphorodithioate
O-Ethyl O-(4-(methylthio)phenyl)phosphorodithioic acid S-propyl ester
Sulprofos
Sulprofos (ACGIH)

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 300 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		NNGADV 12,775,1987
oral/rabbit 390 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleNNGADV 12,775,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >661 mg/m3/4HNNGADV 12,775,1987
intraperitoneal/mouse lethal dose (50 percent kill): 280 mg/kgNNGADV 12,775,1987
intraperitoneal/rat lethal dose (50 percent kill): 160 mg/kgNNGADV 12,775,1987
oral/chicken lethal dose (50 percent kill): 65 mg/kg85INA8 6,1473,1991
oral/mouse lethal dose (50 percent kill): 490 mg/kgNNGADV 12,775,1987
oral/rat lethal dose (50 percent kill): 65 mg/kg85ARAE 1,205,1977
skin/mouse lethal dose (50 percent kill): 5 gm/kgNNGADV 12,775,1987
skin/rabbit lethal dose (50 percent kill): 820 mg/kgFMCHA2 -,C47,1991
skin/rat lethal dose (50 percent kill): 2500 mg/kgNNGADV 12,775,1987
subcutaneous/mouse lethal dose (50 percent kill): >1 gm/kgNNGADV 12,775,1987
subcutaneous/rat lethal dose (50 percent kill): 490 mg/kgNNGADV 12,775,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/chicken lowest published toxic dose: 29610 µg/kg/45D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Musculoskeletal: Other changes		EVMJB9 49,115,1989
oral/Dog lowest published toxic dose: 455 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		NNGADV 12,775,1987
oral/Dog lowest published toxic dose: 1825 mg/kg/2Y- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NNGADV 12,775,1987
oral/mouse lowest published toxic dose: 2079 mg/kg/99W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NNGADV 12,775,1987
oral/rat lowest published toxic dose: 54600 µg/kg/13W- continuousBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NNGADV 12,775,1987
oral/rat lowest published toxic dose: 2628 mg/kg/2Y- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		NNGADV 12,775,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHETOEA 26,321,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,150,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 mg/m3;KZW 2 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SULPROFOS-air10H time-weighted average 1 mg/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

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