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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorous acid, trimethyl ester

RTECS #

TH1400000

CAS #

121-45-9

Updated

September 201

Molecular Weight

124.09

Molecular Formula

C₃H₉O₃P

Synonyms

Fosforyn trojmetylowy (Czech)
Trimethoxyfosfin (Czech)
Trimethoxyphosphine
Trimethyl phosphite
Trimethyl phosphite (ACGIH)
Trimethylfosfit (Czech)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /mammal (species unspecified)	100 mg	mild	MEPAAX 29,393,1978
eye /rabbit	0.1 mL	mild	HPV416 -,-,2005
skin /mammal (species unspecified)	500 mg	mild	MEPAAX 29,393,1978
skin /rabbit	500 mg	severe	34ZIAG -,609,1969
skin /rabbit	0.5 mL	mild	HPV416 -,-,2005

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in mammalian somatic cells	other cell types/mouse	2.7 mL/L (+/-enzymatic activation step)	HPV416 ,,2005

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1640 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 72,119,1984
oral/rat	1640 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis	TXAPA9 72,119,1984
oral/rat	1640 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)	HPV416 -,-,2005

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 51500 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV416 -,-,2005
oral/rat	lowest published toxic dose: 103000 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains	HPV416 -,-,2005

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lethal concentration: >32700 mg/m³/6H	Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity)	NTIS** OTS0537047
inhalation/mouse	Lowest published lethal concentration: 32700 mg/m³/6H	Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity)	NTIS** OTS0537047
inhalation/rat	Lowest published lethal concentration: 32700 mg/m³/6H	Eye: Lacrimation Eye: Ptosis Behavioral: Somnolence (general depressed activity)	NTIS** OTS0537047
inhalation/rat	lethal concentration (50 percent kill): 182000 mg/m³/1H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	HPV416 -,-,2005
inhalation/rat	lethal concentration (50 percent kill): >9000 ppm/4H		HPV416 -,-,2005
intraperitoneal/mouse	lethal dose (50 percent kill): 4180 mg/kg		ENVRAL 9,1,1975
oral/mouse	lethal dose (50 percent kill): 4280 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression	NTIS** OTS0540442
oral/rat	lethal dose (50 percent kill): 1350 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Ulceration or bleeding from stomach	HPV416 -,-,2005
oral/rat	lethal dose (50 percent kill): 1500 mg/kg	Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes Blood: Changes in spleen	HPV416 -,-,2005
oral/rat	lethal dose (50 percent kill): 1600 mg/kg		ALBRW* #OPB-3,1984
skin/rabbit	lethal dose (50 percent kill): 933.8 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage	HPV416 -,-,2005
skin/rabbit	lethal dose (50 percent kill): 2600 mg/kg		AIHAAP 34,286,1973

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 500 ppm/7.5H/8W- intermittent	Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Skin and Appendages: Other: Hair	AIHAAP 34,286,1973
inhalation/rat	lowest published toxic concentration: 292 ppm/4W- intermittent	Eye: Corneal damage Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV416 -,-,2005
inhalation/rat	lowest published toxic concentration: 50 ppm/28D- intermittent	Eye: Corneal damage	HPV416 -,-,2005
inhalation/rat	lowest published toxic concentration: 500 ppm/8W- intermittent	Lung, Thorax, or Respiration: Emphysema Skin: After systemic exposure: Dermatitis, irritative	HPV416 -,-,2005
oral/rat	lowest published toxic dose: 689 mg/kg	Olfaction: Other olfaction effects Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Other changes	NTIS** OTS0540442
oral/rat	lowest published toxic dose: 3444 mg/kg/21D- intermittent	Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV416 -,-,2005
oral/rat	lowest published toxic dose: 14400 mg/kg/90D- intermittent	Liver: Fatty liver degeneration Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV416 -,-,2005
skin/rabbit	lowest published toxic dose: 6300 mg/kg/21D- intermittent	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Liver: Hepatitis (hepatocellular necrosis), diffuse Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV416 -,-,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 741,32,2012

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (10 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 ppm (2.6 mg/m³);KZW 1 ppm (5.2 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (10 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 ppm (2.6 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 ppm (2.6 mg/m³), short term exposure limit 10 ppm (51 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (10 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 ppm (2.6 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 2 ppm (10 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 2 ppm (10 mg/m³);short term exposure limit 5 ppm (25 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 2 ppm (10 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.5 mg(Cd)/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (10 mg/m³), JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (10 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2 ppm (10 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL PHOSPHITE-air	10H time-weighted average 2 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84215; Number of Industries 2; Total Number of Facilities 55; Number of Occupations 18; Total Number of Employees Exposed 14190; Total Number of Female Employees Exposed 6312
National Occupational Hazard Survey 1974	Hazard Code 84215; Number of Industries 5; Total Number of Facilities 260; Number of Occupations 7; Total Number of Employees Exposed 1891

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8977;8EHQ-0892-8988
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9122
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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