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Registry of Toxic Effects of Chemical Substances (RTECS)

Plumbane, tetraethyl-

RTECS #

TP4550000

CAS #

78-00-2

Updated

September 201

Molecular Weight

323.47

Molecular Formula

C8H20Pb

Synonyms

Czteroetylek olowiu (Polish)
Lead, tetraethyl-
NCI-C54988
NSC 22314
Piombo tetra-etile (Italian)
RCRA waste number P110
TEL
Tetraethyl lead
Tetraethyl lead (ACGIH:OSHA)
Tetraethylolovo (Czech)
Tetraethylplumbane
Tetraethylplumbium

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/hamster12500 µg/LAETODY 1,241,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 3 mg/kg (14D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicBNEOBV 58,41,1990
intraperitoneal/rat 1499 µg/kg (13D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system		VHTODE 34,510,1992
intraperitoneal/rat 3 mg/kg (19D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system		VHTODE 34,510,1992
oral/mouse 11 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTXAV 13,629,1975
oral/rat 11 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTXAV 13,629,1975
oral/rat 7500 µg/kg (12-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		TXAPA9 21,265,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 100 mg/kg/21D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease		EXPEAM 24,580,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1749 gm/m3/30MOlfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting		SAIGBL 17,223,1975
inhalation/mouse Lowest published lethal concentration: 650 mg/m3/7HSAIGBL 15,3,1973
inhalation/mouse lethal concentration (50 percent kill): 48.52 mg/m3/2HTPKVAL 9,7,1967
inhalation/mouse lethal concentration (50 percent kill): 3.5 ppm/2HTPKVAL 9,7,1967
inhalation/rat lethal concentration (50 percent kill): 850 mg/m3/1HBehavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis		BJIMAG 18,277,1961
intraperitoneal/rat lethal dose (50 percent kill): 15 mg/kgMELAAD 54,486,1963
intravenous/rabbit lowest published lethal dose: 22 mg/kgEQSSDX 1,1,1975
intravenous/rat lethal dose (50 percent kill): 14400 µg/kgMELAAD 54,486,1963
oral/rabbit lowest published lethal dose: 30 mg/kgSAIGBL 15,3,1973
oral/rat lethal dose (50 percent kill): 12300 µg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression		EXPEAM 28,923,1972
parenteral/rat lethal dose (50 percent kill): 15 mg/kgAOHYA3 3,226,1961
skin/Dog lowest published lethal dose: 547 mg/kgSAIGBL 15,3,1973
skin/guinea pig lowest published lethal dose: 995 mg/kgSAIGBL 15,3,1973
skin/rabbit lowest published lethal dose: 830 mg/kgSAIGBL 15,3,1973
subcutaneous/mouse lethal dose (50 percent kill): 13020 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Convulsions or effect on seizure threshold		FKIZA4 49,2779,1958
subcutaneous/rabbit lowest published lethal dose: 32 mg/kgEQSSDX 1,1,1975
unreported route/man lowest published lethal dose: 1470 µg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1100 mg/m3/1H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTIS** OTS0533656-1
intravenous/monkey lowest published toxic dose: 42 mg/kg/7D- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TOLED5 2,187,1978
oral/mouse lowest published toxic dose: 10 mg/kg/5D- intermittentBehavioral: TremorNTPTR* NTR-IMM-20009
oral/mouse lowest published toxic dose: 14 mg/kg/14D- intermittentBlood: Normocytic anemia

Blood: Luekopenia

Blood: Changes in erythrocyte (RBC) count		NTPTR* IMM-20009
oral/mouse lowest published toxic dose: 14 mg/kg/14D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Renal function tests depressed

Immunological Including Allergic: Decrease in cellular immune response		NTPTR* IMM-20009
oral/mouse lowest published toxic dose: 14 mg/kg/14D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Decreased immune response		NTPTR* IMM-20009
oral/rat lowest published toxic dose: 2520 µg/kg/6W- continuousEndocrine: Other changesJANSY* 8,287,1983
skin/Dog lowest published toxic dose: 504 µL/kg/21D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFKIZA4 49,2779,1958

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Pb)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,230,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,325,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,230,1987
TOXICOLOGY REVIEWJORCAI 76,265,1974
TOXICOLOGY REVIEWJAMAAP 105,578,1935
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEW85DHAX Pb,255,1972
TOXICOLOGY REVIEWIMEMDT 87,225,
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNBREV* 26,81,2002

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg(Pb)/m3 (skin)DTLVS* 3,251,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Pb)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(Pb)/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.007 ppm (0.05 mg(Pb)/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.075 mg(Pb)/m3, short term exposure limit 0.23 mg(Pb)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg(Pb)/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg(Pb)/m3, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.075 mg(Pb)/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.075 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg(Pb)/m3;short term exposure limit 0.3 mg(Pb)/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.005 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Pb)/m3;short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg/m3, KZG-week 0.1 mg/m3, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.075 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.075 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(Pb)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.075 mg(Pb)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.075 mg(Pb)/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg(Pb)/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAETHYLLEAD (as Pb)-air10H time-weighted average 0.075 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 71640; Number of Industries 6; Total Number of Facilities 729; Number of Occupations 15; Total Number of Employees Exposed 36802; Total Number of Female Employees Exposed 1099
National Occupational Hazard Survey 1974Hazard Code 71640; Number of Industries 1; Total Number of Facilities 85; Number of Occupations 6; Total Number of Employees Exposed 799

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl lead (as Pb), 2533
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database

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