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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 2-methyl-

RTECS #

TZ4300000

CAS #

75-28-5

Updated

September 201

Molecular Weight

58.14

Molecular Formula

C4H10

Synonyms

1,1-Dimethylethane
2-Methylpropane
A 31 (hydrocarbon)
R 600a
Trimethylmethane

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 70000 ppm/5MCardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Other changes		HPV330 -,-,2000
inhalation/human lowest published toxic concentration: 280 mg/m3Brain and Coverings: Changes in surface EEGTOVEFN (3),38,2000
inhalation/mammal (species unspecified) lowest published toxic concentration: 58600 mg/m3Lung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		TOVEFN (3),38,2000
inhalation/mouse Lowest published lethal concentration: 1041 gm/m3/2HBehavioral: ExcitementJPETAB 58,74,1936
inhalation/mouse lowest published toxic concentration: 500000 mg/m3/2HBehavioral: AtaxiaTOVEFN (3),38,2000
inhalation/mouse lethal concentration (16 percent kill): 530000 mg/m3/2HBehavioral: General anestheticTOVEFN (3),38,2000
inhalation/mouse lethal concentration (50 percent kill): 680000 mg/m3/2HTOVEFN (3),38,2000
inhalation/rat lethal concentration (16 percent kill): 537000 mg/m3/4HBehavioral: General anestheticTOVEFN (3),38,2000
inhalation/rat lethal concentration (50 percent kill): 658000 mg/m3/4HTOVEFN (3),38,2000
inhalation/rat lethal concentration (50 percent kill): 570000 ppm/15MBehavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression		HPV330 -,-,2000
inhalation/rat lowest published toxic concentration: 200000 ppm/10MBehavioral: ExcitementHPV330 -,-,2000
inhalation/rat lethal concentration (50 percent kill): 57 pph/15MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression		HUTODJ 1,239,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 1000 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAZMAE 18,365,1974
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm ( mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 800 ppm (1900 mg/m3), short term exposure limit 1000 ppm (2400 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 1000 ppm (2400 mg/m3), 2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 500 ppm (1200 mg/m3), MAY2012
Occupational Exposure Limit-SWITZERLANDMAK-week 800 ppm (1900 mg/m3), JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81851; Number of Industries 377; Total Number of Facilities 110810; Number of Occupations 233; Total Number of Employees Exposed 1795168; Total Number of Female Employees Exposed 556159
National Occupational Hazard Survey 1974Hazard Code 81851; Number of Industries 360; Total Number of Facilities 118992; Number of Occupations 199; Total Number of Employees Exposed 1193478

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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