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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,2,3-trichloro-

RTECS #

TZ9275000

CAS #

96-18-4

Updated

September 201

Molecular Weight

147.43

Molecular Formula

C3H5Cl3

Synonyms

1,2,3-Trichloropropane
1,2,3-Trichloropropane (ACGIH:OSHA)
Allyl trichloride
Glycerol trichlorohydrin
Glyceryl trichlorohydrin
NCI-C60220
Trichlorohydrin

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL moderateNTIS** OTS0534994
skin /rabbit 500 µL/24H mildNTIS** OTS0534994

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat800 µg/LBEXBAN 78,1414,1974
DNA Damagelymphocyte/human2 mmol/LMUREAV 371,185,1996
DNA Damageintraperitoneal/rat55361 µg/kgCRTOEC 4,528,1991
mutation in microorganisms/Salmonella typhimurium500 ng/plate (-enzymatic activation step)ENMUDM 7(Suppl 3),15,1985
sister chromatid exchangelung/hamster300 µmol/LENMUDM 9,401,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 400 mg/kg (5D male)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)MUREAV 101,321,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 3120 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors		NTPTR* NTP-TR-384,1993
oral/mouse lowest published toxic dose: 3120 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors		NTIS** PB94-207784
oral/mouse lowest published toxic dose: 31200 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Tumors		NTIS** PB94-207784
oral/rat lowest published toxic dose: 5200 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors		NTPTR* NTP-TR-384,1993
oral/rat lowest published toxic dose: 1560 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors		NTIS** PB94-207784
oral/rat lowest published toxic dose: 15600 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Reproductive: Other reproductive system tumors		NTIS** PB94-207784
oral/rat lowest published toxic dose: 5200 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Other reproductive system tumors		NTIS** PB94-207784

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 3400 mg/m3/2HVCVGH* -,397,1990
inhalation/rat Lowest published lethal concentration: 500 ppm/4HUCDS** 3/20/1973
oral/Dog lowest published lethal dose: 200 mg/kgBehavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration		AJHYA2 16,325,1932
oral/guinea pig lethal dose (50 percent kill): 340 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes		TKGMB8 124,27,1976
oral/mouse lethal dose (50 percent kill): 369 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes		TKGMB8 124,27,1976
oral/rabbit lethal dose (50 percent kill): 380 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes		TKGMB8 124,27,1976
oral/rat lethal dose (50 percent kill): 108 µL/kgGastrointestinal: Hypermotility, diarrhea

Liver: Other changes

Skin and Appendages: Other: Hair		NTIS** OTS0534994
skin/rabbit lethal dose (50 percent kill): 372 µL/kgGastrointestinal: Hypermotility, diarrhea

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes		NTIS** OTS0534994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3210 mg/m3/5H/23D- intermittentBlood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGH* -,398,1990
inhalation/rat lowest published toxic concentration: 297 ppm/6H/4W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in ovarian weight		JTEHD6 25,299,1988
inhalation/rat lowest published toxic concentration: 2 mg/m3/24H/94D- continuousBrain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 42(8),50,1977
inhalation/rat lowest published toxic concentration: 15 ppm/6H/13W- intermittentEye: Lacrimation

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0542010
oral/mouse lowest published toxic dose: 5355 mg/kg/17W- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes		NTPTR* NTP-TR-384,1993
oral/rat lowest published toxic dose: 2720 mg/kg/17W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases		NTPTR* NTP-TR-384,1993
oral/rat lowest published toxic dose: 1179 mg/kg/10D- intermittentCardiac: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		JJATDK 11,179,1991
unreported route/rat lowest published toxic dose: 3210 mg/m3/90D- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		VCVGH* -,398,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 63,223,1995
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,223,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 63,223,1995
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWFCTOD7 48,1488,2010
TOXICOLOGY REVIEWMUREAV 751,49,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (300 mg/m3)DTLVS* 3,266,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (60 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (300 mg/m3);KZW 250 ppm (1500 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (61 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 3 ppm (18 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (60 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (60 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (300 mg/m3);short term exposure limit 75 ppm (450 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (60 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.108 mg/m3, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (300 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (300 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (300 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (300 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2,3-TRICHLOROPROPANE-air10H Carcinogen time-weighted average 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 73960; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 492; Total Number of Female Employees Exposed 10
National Occupational Hazard Survey 1974Hazard Code 73960; Number of Industries 4; Total Number of Facilities 108; Number of Occupations 5; Total Number of Employees Exposed 490

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110872/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9216
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000
On EPA IRIS database

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