Registry of Toxic Effects of Chemical Substances (RTECS)
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2-Propanol, 1-methoxy-
RTECS #
UB7700000CAS #
107-98-2Updated
September 201Molecular Weight
90.14Molecular Formula
C4H10O2Synonyms
1-Methoxy-2-propanolalpha-Propylene glycol monomethyl ether
Dowanol 33B
Dowanol PM
Dowanol PM glycol ether
Dowtherm 209
Glycol ether PM
Methoxy ether of propylene glycol
Methyl proxitol
PGME
Poly-Solve MPM
Propasol solvent M
Propylene glycol methyl ether
Propylene glycol monomethyl ether
Propylene glycol monomethyl ether (ACGIH)
Propylenglykol-monomethylaether (German)
Ucar Solvent LM (Obs.)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,625,1986 |
| skin /rabbit | 500 mg open irritation test | mild | UCDS** 11/15/1971 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 3000 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | FAATDF 4,784,1984 |
| inhalation/rat | 3000 ppm/6H (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Physical | TOSCF2 50,249,1999 |
| oral/mouse | 3.3 gm/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86170578 |
| oral/mouse | 3.3 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB86170578 |
| oral/mouse | 3.3 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86170578 |
| oral/mouse | 115.5 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86170578 |
| oral/rabbit | 936 mg/kg (7-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TOSCF2 71,217,2003 |
| oral/rat | 50501.25 mg/kg (15D prior to copulation) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TIHEEC 21,33,2005 |
| oral/rat | 59395.5 mg/kg (15D prior to copulation) | Reproductive: Other effects on female Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | TIHEEC 21,33,2005 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | Lowest published lethal concentration: 15000 ppm/7H | Behavioral: Sleep | AMIHBC 9,509,1954 |
| inhalation/human | lowest published toxic concentration: 3000 ppm | Olfaction: Tumors Behavioral: General anesthetic Gastrointestinal: Nausea or vomiting | NPIRI* 1,105,1974 |
| inhalation/human | lowest published toxic concentration: 2580 mg/m3 | Eye: Lacrimation | VCVGK* -,169,1984 |
| inhalation/human | lowest published toxic concentration: 7540 mg/m3 | Eye: Conjunctiva irritation | VCVGK* -,169,1984 |
| inhalation/human | lowest published toxic concentration: 830 mg/m3/1H | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,170,1984 |
| inhalation/mouse | lowest published toxic concentration: 1000 ppm | Liver: Other changes | TOXID9 72,178,2003 |
| inhalation/mouse | lowest published toxic concentration: 3000 ppm | Behavioral: Antianxiety | TOXID9 72,178,2003 |
| inhalation/rabbit | Lowest published lethal concentration: 15000 ppm/7H | AMIHBC 9,509,1954 | |
| inhalation/rat | lowest published toxic concentration: 18400 mg/m3 | Behavioral: Alteration of classical conditioning | VCVGK* -,169,1984 |
| inhalation/rat | lethal concentration (50 percent kill): 10000 ppm/5H | NPIRI* 1,105,1974 | |
| inhalation/rat | lowest published toxic concentration: 3000 ppm | Behavioral: Antianxiety | TOXID9 72,178,2003 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm | Liver: Other changes | TOXID9 72,178,2003 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm | Kidney, Ureter, and Bladder: Other changes | TOXID9 72,178,2003 |
| intraperitoneal/mouse | Lethal dose: >500 mg/kg | CBCCT* 4,110,1952 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 3720 mg/kg | 38MKAJ 2C,3977,1982 | |
| intravenous/Dog | lethal dose (50 percent kill): 2 gm/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | ARZNAD 22,569,1972 |
| intravenous/mouse | lethal dose (50 percent kill): 5300 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | ARZNAD 22,569,1972 |
| intravenous/rabbit | lethal dose (50 percent kill): 1200 mg/kg | ARZNAD 22,569,1972 | |
| intravenous/rat | lethal dose (50 percent kill): 4200 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | ARZNAD 22,569,1972 |
| oral/Dog | lethal dose (50 percent kill): 5 gm/kg | ARZNAD 22,569,1972 | |
| oral/mouse | lethal dose (50 percent kill): 11700 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | ARZNAD 22,569,1972 |
| oral/rabbit | lethal dose (50 percent kill): 5700 mg/kg | ARZNAD 22,569,1972 | |
| oral/rat | lethal dose (50 percent kill): 6600 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: General anesthetic Lung, Thorax, or Respiration: Dyspnea | VCVGK* -,169,1984 |
| oral/rat | lowest published lethal dose: 3739 mg/kg | Eye: Chromodacryorrhea Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia | NTIS** OTS0520402 |
| skin/rabbit | lethal dose (50 percent kill): 13 gm/kg | NPIRI* 1,105,1974 | |
| subcutaneous/rabbit | lethal dose (50 percent kill): 5 gm/kg | ARZNAD 22,569,1972 | |
| subcutaneous/rat | lethal dose (50 percent kill): 7800 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | ARZNAD 22,569,1972 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 6000 ppm/7H/16W- intermittent | Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHBC 9,509,1954 |
| inhalation/monkey | lowest published toxic concentration: 10000 ppm/4H/13W- intermittent | Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AMIHBC 9,509,1954 |
| inhalation/mouse | lowest published toxic concentration: 3000 ppm/6H/11D- intermittent | Liver: Changes in liver weight | TXAPA9 61,368,1981 |
| inhalation/rabbit | lowest published toxic concentration: 3000 ppm/6H/13W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FAATDF 3,627,1983 |
| inhalation/rat | lowest published toxic concentration: 3000 ppm/6H/11D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition | TXAPA9 61,368,1981 |
| inhalation/rat | lowest published toxic concentration: 3000 ppm/6H/13W- intermittent | Liver: Changes in liver weight | FAATDF 3,627,1983 |
| inhalation/rat | lowest published toxic concentration: 11000 mg/m3/6H/9D- intermittent | Brain and Coverings: Other degenerative changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition | VCVGK* -,170,1994 |
| inhalation/rat | lowest published toxic concentration: 2200 mg/m3/12D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,170,1994 |
| multiple/human | lowest published toxic dose: 100 ppm/3H/2W- intermittent | Olfaction: Other olfaction effects | TOLED5 135,S30,2002 |
| multiple/human | lowest published toxic dose: 150 ppm/3H/2W- intermittent | Olfaction: Other olfaction effects Eye: Conjunctiva irritation | TOLED5 135,S30,2002 |
| oral/mouse | lowest published toxic dose: 40 mL/kg/2W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,170,1994 |
| oral/mouse | lowest published toxic dose: 40 mL/kg/2W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,170,1994 |
| oral/rat | lowest published toxic dose: 40 mL/kg/2W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,170,1994 |
| oral/rat | lowest published toxic dose: 40 mL/kg/2W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Blood: Luekopenia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,170,1994 |
| oral/rat | lowest published toxic dose: 280435.2 mg/kg/64D- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TIHEEC 21,33,2005 |
| skin/rabbit | lowest published toxic dose: 900 mL/kg/90D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVGK* -,170,1994 |
| skin/rabbit | lowest published toxic dose: 455 mL/kg/13W- intermittent | Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHBC 9,509,1954 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FAATDF 13,747,1989 | |
| TOXICOLOGY REVIEW | CRTXB2 30,307,2000 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,249,2003 | |
| TOXICOLOGY REVIEW | ENTOX* -,451,2005 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (360 mg/m3) | DTLWS* 3,27,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 50 ppm (187 mg/m3);KZW 50 ppm (187 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 100 ppm (375 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 150 ppm (568 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 50 ppm (185 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 375 mg/m3 (100 ppm);short term exposure limit 568 mg/m3 (150 ppm), skin, JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 100 ppm (370 mg/m3), short term exposure limit 150 ppm (560 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 100 ppm (375 mg/m3), VLE 150 ppm (568 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 100 ppm (370 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 375 mg/m3, short term exposure limit 568 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 50 ppm (185 mg/m3), short term exposure limit 150 ppm (568 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 100 ppm (360 mg/m3), short term exposure limit 150 ppm (540 mg/m3), 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 50 ppm (180 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 100 ppm (369 mg/m3); short term exposure limit 150 ppm (553 mg/m3), JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 50 ppm (190 mg/m3);short term exposure limit 75 ppm (300 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 100 ppm (360 mg/m3), KZG-week 200 ppm (720 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 375 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 100 ppm (375 mg/m3);short term exposure limit 150 ppm (560 mg/m3), skin, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air | 10H time-weighted average 100 ppm;short term exposure limit 150 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 81815; Number of Industries 204; Total Number of Facilities 25947; Number of Occupations 133; Total Number of Employees Exposed 373990; Total Number of Female Employees Exposed 110572 | |
| National Occupational Hazard Survey 1974 | Hazard Code 81815; Number of Industries 44; Total Number of Facilities 5953; Number of Occupations 36; Total Number of Employees Exposed 26413 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division