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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanone, 1,1,1,3,3,3-hexafluoro-

RTECS #

UC2450000

CAS #

684-16-2

Updated

September 201

Molecular Weight

166.03

Molecular Formula

C3F6O

Synonyms

6FK
Acetone, hexafluoro-
Hexafluoroacetone
Hexafluoroacetone (ACGIH)
NCI-C56440

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 12 ppm/6H (30D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		TXCYAC 67,249,1991
skin/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 2,73,1982
skin/rat 55 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 41,195,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 30600 mg/m3/45MVascular: BP lowering not characterized in autonomic sectionVCVGK* -,437,1994
inhalation/rat lethal concentration (50 percent kill): 275 ppm/3HTXAPA9 6,341,1964
inhalation/rat lethal concentration (50 percent kill): 5520 mg/m3/30MBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes		VCVGK* -,437,1994
inhalation/rat lethal concentration (50 percent kill): 1690 mg/m3/3HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes		VCVGK* -,437,1994
oral/rat lethal dose (50 percent kill): 191 mg/kgTXAPA9 6,341,1964
skin/rat lowest published toxic dose: 39 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)VCVGK* -,437,1994
skin/rat lowest published toxic dose: 13 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductVCVGK* -,437,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rat lowest published toxic dose: 117 mg/kg/3D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductVCVGK* -,437,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.7 mg/m3)DTLWS* 3,20,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.68 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.7 mg/m3);KZW 0.2 ppm (1.4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.69 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.7 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.69 mg/m3), short term exposure limit 0.3 ppm (2.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.7 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.7 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.7 mg/m3);short term exposure limit 0.3 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.68 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,68 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.7 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXAFLUOROACETONE-air10H time-weighted average 0.1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 83899; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 1; Total Number of Employees Exposed 141

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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