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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionitrile, 3-(dimethylamino)-

RTECS #

UG1575000

CAS #

1738-25-6

Updated

February 2007

Molecular Weight

98.17

Molecular Formula

C5H10N2

Synonyms

3-(Dimethylamino)propionitrile
3-Dimethylaminopropannitril (Czech)
beta-Dimethylaminopropionitrile

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,923,1986
skin /rabbit 500 mg/24H mild85JCAE -,923,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgTOVEFN (1),19,1996
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgCSLNX* NX#00201
oral/mouse lethal dose (50 percent kill): 1500 mg/kg85JCAE -,923,1986
oral/rat lethal dose (50 percent kill): 2600 µL/kgAIHAAP 23,95,1962
skin/rabbit lethal dose (50 percent kill): 1410 µL/kgAIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 9 mg/m3/122D- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Other changes

Liver: Other changes		TOVEFN (1),19,1996
inhalation/rat lowest published toxic concentration: 9 mg/m3/122D- intermittentKidney, Ureter, and Bladder: Other changesTOVEFN (1),19,1996
inhalation/rat lowest published toxic concentration: 9 mg/m3/122D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOVEFN (1),19,1996
intraperitoneal/rat lowest published toxic dose: 500 mg/kg/3D- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		TOVEFN (1),19,1996
intraperitoneal/rat lowest published toxic dose: 182.6 mg/kg/30D- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)		TOVEFN (1),19,1996

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINOPROPIONITRILE-airmin expos to NIAXNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code M3293; Number of Industries 2; Total Number of Facilities 145; Number of Occupations 3; Total Number of Employees Exposed 1990

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978

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