Registry of Toxic Effects of Chemical Substances (RTECS)

Propyl alcohol

RTECS #

UH8225000

CAS #

71-23-8

Updated

September 201

Molecular Weight

60.11

Molecular Formula

C₃H₈O

Synonyms

1-Hydroxypropane
1-Propanol
1-Propyl alcohol
Alcool propilico (Italian)
Alcool propylique (French)
Ethyl carbinol
n-Propanol
n-Propyl alcohol
n-Propyl alcohol (ACGIH:OSHA)
n-Propyl alkohol (German)
Optal
Osmosol Extra
Propan-1-ol
Propanol
Propanol-1
Propanole (German)
Propanolen (Dutch)
Propanoli (Italian)
Propylic alcohol
Propylowy alkohol (Polish)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	20 mg/24H	moderate	85JCAE -,191,1986
skin /human	100%/47H	mild	CODEDG 39,240,1998
skin /human	100%/24H	mild	CODEDG 68,192,1988
skin /rabbit	500 mg open irritation test	mild	UCDS** 6/28/1972

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Escherichia coli	4 pph (-enzymatic activation step)	ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction	/Aspergillus nidulans	18000 ppm	MUREAV 215,187,1989

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	7000 ppm/7H (6W male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	NTOTDY 7,779,1985
inhalation/rat	7000 ppm/7H (1-19D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FCTOD7 26,247,1988
inhalation/rat	10000 ppm/7H (1-19D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system	FCTOD7 26,247,1988

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 50 gm/kg/81W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975
subcutaneous/rat	lowest published toxic dose: 6 gm/kg/95W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 220 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
inhalation/mouse	lethal concentration (50 percent kill): 48000 mg/m³	Behavioral: General anesthetic Lung, Thorax, or Respiration: Other changes	VCVGK* -,96,1984
inhalation/mouse	lethal concentration (50 percent kill): 48 gm/m³		GTPZAB 18(3),48,1974
inhalation/rat	Lowest published lethal concentration: 4000 ppm/4H		AMIHBC 10,61,1954
inhalation/rat	Lowest published lethal concentration: 9800 mg/m³/4H	Behavioral: General anesthetic Lung, Thorax, or Respiration: Other changes	VCVGK* -,96,1984
intraperitoneal/guinea pig	lethal dose (50 percent kill): 1208 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/hamster	lethal dose (50 percent kill): 2338 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/mouse	lethal dose (50 percent kill): 3125 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/rabbit	lethal dose (50 percent kill): 515 mg/kg		EVHPAZ 61,321,1985
intraperitoneal/rat	lethal dose (50 percent kill): 2164 mg/kg		EVHPAZ 61,321,1985
intravenous/cat	lowest published lethal dose: 4008 mg/kg		JPETAB 16,1,1920
intravenous/mouse	lethal dose (50 percent kill): 697 mg/kg		EVHPAZ 61,321,1985
intravenous/rabbit	lethal dose (50 percent kill): 483 mg/kg		EVHPAZ 61,321,1985
intravenous/rat	lethal dose (50 percent kill): 590 mg/kg		EVHPAZ 61,321,1985
oral/Dog	lowest published lethal dose: 3 gm/kg	Gastrointestinal: Other changes Blood: Hemorrhage	COREAF 81,192,1875
oral/mouse	lethal dose (50 percent kill): 6800 mg/kg		PSDTAP 9,276,1968
oral/mouse	lowest published lethal dose: 140 mg/kg	Behavioral: General anesthetic	VCVGK* -,96,1984
oral/rabbit	lowest published lethal dose: 3500 mg/kg	Behavioral: General anesthetic	VCVGK* -,96,1984
oral/rabbit	lethal dose (50 percent kill): 2825 mg/kg		IMSUAI 41,31,1972
oral/rat	lethal dose (50 percent kill): 1870 mg/kg		AMIHBC 10,61,1954
oral/rat	lethal dose (50 percent kill): 2200 mg/kg	Behavioral: General anesthetic	VCVGK* -,96,1984
oral/woman	lowest published lethal dose: 5700 mg/kg	Cardiac: Other changes Lung, Thorax, or Respiration: Other changes	ATXKA8 16,84,1956
skin/rabbit	lethal dose (50 percent kill): 5040 mg/kg		AMIHBC 10,61,1954
subcutaneous/Dog	lowest published lethal dose: 4 gm/kg	Gastrointestinal: Other changes Blood: Hemorrhage	COREAF 81,192,1875
subcutaneous/mammal (species unspecified)	lowest published lethal dose: 5 gm/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: General anesthetic Lung, Thorax, or Respiration: Other changes	ATXKA8 16,84,1956
subcutaneous/mouse	lethal dose (50 percent kill): 4700 mg/kg		TXAPA9 18,185,1971
subcutaneous/rabbit	lowest published lethal dose: 3 gm/kg		BDBU** -,-,1930
unreported route/rabbit	lowest published lethal dose: 4500 mg/kg		THMOAM 6,327,1892

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 20 mg/m³/24H/90D- continuous	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Liver: Multiple effects	VCVGK* -,98,1994
oral/rat	lowest published toxic dose: 7 mL/kg/7D- intermittent	Liver: Other changes Biochemical: Effect on specific coenzyme: B vitamins including folate	JDGRAX 10(1-2),25,1978

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 140-141,53,2003
TOXICOLOGY REVIEW		REPTED 32,142,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 200 ppm (490 mg/m³)	DTLVS* 3,217,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (492 mg/m³), short term exposure limit 250 ppm (614 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 200 ppm (500 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm (499 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 250 ppm (623 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 200 ppm (500 mg/m³), skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 200 ppm (500 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 200 ppm (500 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 200 ppm (500 mg/m³), short term exposure limit 250 ppm (625 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 200 ppm (500 mg/m³);short term exposure limit 250 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (492 mg/m³), short term exposure limit 250 ppm (614 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 100 ppm (245 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 200 ppm (491 mg/m³); short term exposure limit 250 ppm (614 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 200 mg/m³, MAC(short term exposure limit) 600 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 10 mg/m³, short term exposure limit 30 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 150 ppm (350 mg/m³);short term exposure limit 250 ppm (600 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 200 ppm (500 mg/m³), skin, JAN2011
Occupational Exposure Limit-TURKEY	time-weighted average 200 ppm (500 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 200 ppm (500 mg/m³);short term exposure limit 250 ppm (625 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 200 ppm (500 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 200 ppm (500 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 200 ppm (500 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 200 ppm (500 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYL ALCOHOL-air	time-weighted average 200 ppm (Sk);short term exposure limit 250 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0256; Number of Industries 130; Total Number of Facilities 17036; Number of Occupations 99; Total Number of Employees Exposed 226129; Total Number of Female Employees Exposed 84196
National Occupational Hazard Survey 1974	Hazard Code M0256; Number of Industries 151; Total Number of Facilities 18176; Number of Occupations 103; Total Number of Employees Exposed 122603

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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